Showing Protein N-arachidonyl glycine receptor (BMDBP02240)
Identification | |
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BMDB Protein ID | BMDBP02240 |
Secondary Accession Numbers | None |
Name | N-arachidonyl glycine receptor |
Synonyms | Not Available |
Gene Name | GPR18 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Involved in purinergic nucleotide receptor activity, G- |
Specific Function | Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8 alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis. |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 12 |
Locus | Not Available |
SNPs | GPR18 |
Gene Sequence |
>999 bp ATGACCACCCCTCACAGTCAAGCTCAACCTGGCCTTCCTATCGACCCACATCCAGATGAA TACAAGGTGGCAGCCCTCGTCTTCTACAGCTGCATCTTCATCATTGGATTATTTGTCAAC GTCACCGCCTTATGGGTTTTCAGTTGCACCACCAAGAAGAGAACCACTGTGACCGTCTAT ATGATGAACGTGGCGCTACTGGACTTGGTGTTTATAATGAGCTTACCCTTTCGGATGCTT TACTACGCAAAAGGTGAATGGCCTTTTGGAGAGTACTTTTGCCGGATTCTTGGGGCTCTC ACAGTGTTTTACCCGAGTATTGCTCTGTGGCTTCTCGCCTTTATTAGTGCTGACAGATAC ATGGCCATCGTACAGCCGAAATATGCCAAGGAACTTAAAAACACGTGCAAGGCCGTGATG GCGTGTGTGGGCGTCTGGATAATGACCCTGACCACCACCATCCCACTCCTGCTGCTCTAT GAAGACCCAGACACAGCCTCCTCCACCCCCCCTACCTGCCTCAAGATTTCTGACATCATT TACTTAAAAGCTATTAATGCGCTGAACTTCACTCGACTGATATTTTTTTTCTTGATTCCT CTGTTCATCATGATTGGGTGCTACTTGGTCATTATCCATAGTCTCCTTCATGGTAAGACC TCTAAGCTGAAGCCAAAGGTCAAGGAGAAGTCGATCCGGATCATCATCACGCTGATGGTG CAGGTGCTGGTCTGCTTCATGCCCTTCCACATTTGCTTTGCTTTCCTGATGCTGGGAGGG GATGAGAACAGCTACAACCCCTGGGGAGCCTTCACCACCTTCCTCATGAACCTCAGCACT TGTCTGGACGTGATTCTCTACTACATCGTTTCGAAACAATTTCAGGCTCGAGTCATTAGC GTCATGCTGTACCGTAATTACCTTCGGAGCGTGCGCAGAAAGAGCTTCCGCTCAGGTAGC TTACGGTCACTAAGCAACATAAACAGTGAAATGTTATGA |
Protein Properties | |
Number of Residues | 332 |
Molecular Weight | 37949.0 |
Theoretical pI | 9.47 |
Pfam Domain Function | Not Available |
Signals |
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Transmembrane Regions |
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Protein Sequence |
>N-arachidonyl glycine receptor MTTPHSQAQPGLPIDPHPDEYKVAALVFYSCIFIIGLFVNVTALWVFSCTTKKRTTVTVY MMNVALLDLVFIMSLPFRMLYYAKGEWPFGEYFCRILGALTVFYPSIALWLLAFISADRY MAIVQPKYAKELKNTCKAVMACVGVWIMTLTTTIPLLLLYEDPDTASSTPPTCLKISDII YLKAINALNFTRLIFFFLIPLFIMIGCYLVIIHSLLHGKTSKLKPKVKEKSIRIIITLMV QVLVCFMPFHICFAFLMLGGDENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVIS VMLYRNYLRSVRRKSFRSGSLRSLSNINSEML |
External Links | |
GenBank ID Protein | AAI02422.1 |
UniProtKB/Swiss-Prot ID | Q3T0E9 |
UniProtKB/Swiss-Prot Entry Name | GPR18_BOVIN |
PDB IDs | Not Available |
GenBank Gene ID | BC102421 |
GeneCard ID | GPR18 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |