| Identification |
|---|
| BMDB Protein ID
| BMDBP02261 |
| Secondary Accession Numbers
| None |
| Name
| Amiloride-sensitive sodium channel subunit beta |
| Synonyms
|
Not Available
|
| Gene Name
| SCNN1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in amiloride-sensitive sodium channel activity |
| Specific Function
| Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| SCNN1B |
| Gene Sequence
|
>1926 bp
ATGCACGTAAAGAAGTACCTGCTCAAGGGCCTGCATCGGCTGCAGAAGGGCCCTGGCTAC
ACATACAAGGAGCTGCTGGTGTGGTACTGTGACAACACCAACACCCATGGCCCCAAGCGC
ATCATCTGCGAGGGGCCCAAGAAGAAGGCCATGTGGTTCGTGCTCACCTTGCTCTTCACC
TCCCTCGTCTGCTGGCAGTGGGGCCTCTTCATCAAGACCTACCTGAACTGGGAGGTCAGC
GTCTCCCTCTCCATCGGCTTCAAGACCATGGACTTCCCCGCGGTCACCATCTGCAACGCC
AGCCCCTTCCAGTACTCCAAAGTCCAGCATTTGCTGAAGGACCTGGACGAACTGATGGAG
GCAGTCTTGGGGAGGATCCTGGGTCCCGAGCTCAGCCAGGTCAATGACACCAGGGCCCTG
AACCTGTCCATCTGGCACCACACGCCCCTGGTCTTTATCAACGAGCAGAACCCCCACCAC
CCGGTGGTTCTGGACCTGTTTGAGGACAACTTCAATGGCTCAGCAAGCAACAGCCCAGCA
CCAGGAAGGCCCTGCAGTGCCCACAGGTGCAAAGTAGCCATGAGACTATGCAGCCACAAT
GGAACCACGTGTACCTTCCGGAACTTCAGCAGCGCCACCCAGGCCGTGACGGAGTGGTAC
ACCCTGCAGGCCACCAACATCTTTGCACAGGTTCCAAACCAGGAGCTGGTGGCCATGGGC
TACCCTGCCGAGCGGCTGATCCTGGCCTGCCTGTTCGGGGCAGAGCCCTGCAACTACAGG
AACTTCACACCCATCTTCCACCCTGATTATGGCAACTGTTACATCTTCAACTGGGGCATG
ACGGAGAAGGCCCTCCCTTCAGCCAACCCGGGAACTGAGTTCGGCCTAAAACTGATCCTG
GACATGGGCCAGGAAGACTACGTCCCCTTCCTCACCTCTACGGCTGGCGCCCGGCTGATG
CTTCACGAGCAGAGGTCATACCCCTTCATCAAGGAAGAGGGCATCTATGCCATGGCGGGG
ATGGAGACATCCATCGGGGTGCTTGTGGACAAGCTGCAGCGCAAGGGCGAGCCCTACAGC
CAGTGCACCAAGAACGGCTCTGACGTCCCCATCCAAAACCTCTACAGCAACTACAACACG
ACCTACTCCATCCAGGCCTGTATTCGCTCCTGCTTCCAGGAGCACATGATTCGGGAATGT
GGTTGTGGCCACTACCTGTACCCGCTGCCCCACAAGAGGAAATACTGCAACAACCAGGAG
TTTCCGGACTGGGCCCATTGCTACTCGGCCCTGCGCATCAGCCTGGCGCAGAGGGAGACC
TGCATCTACGCCTGTAAGGAGTCCTGCAATGACACTCAGTACAAGATGACCATCTCCATG
GCCGTCTGGCCTTCCGAGGCCTCCGAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGG
GACCAAAGCAGCAATATCACCTTGAGCAGGAAGGGGATTGTCAAGCTCAATATCTACTTC
CAAGAATTCAACTATCGCACCATTGAAGAGTCAGCAGCCAATAATATCGTCTGGCTGCTC
TCAAACCTGGGCGGACAGTTCGGCTTCTGGATGGGGGGCTCGGTGCTCTGCCTCATCGAG
TTCGGGGAGATCATCATCGATTTCGTGTGGATCACCATCATCAAGCTGGTGGCCCTCGCC
AAGAGCGTGCGGCAGAAGCGGGCCCAGGCTCGCTACGAAGGCCCGCCGCCCACTGTGGCC
GAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCAGACTTGGCCACACCCGGCCCT
GACGTGGAGGCCTACCCCCACGAGCAGAACCCGCCCATCCCGGGCACCCCACCCCCCAAC
TACGACTCCCTGCGCCTGCAGCCGCTGGACGTCATTGAGTCTGACAGCGAGGGGGATGCC
ATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 641 |
| Molecular Weight
| 72677.0 |
| Theoretical pI
| 6.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>SCNN1B protein
MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFVLTLLFT
SLVCWQWGLFIKTYLNWEVSVSLSIGFKTMDFPAVTICNASPFQYSKVQHLLKDLDELME
AVLGRILGPELSQVNDTRALNLSIWHHTPLVFINEQNPHHPVVLDLFEDNFNGSASNSPA
PGRPCSAHRCKVAMRLCSHNGTTCTFRNFSSATQAVTEWYTLQATNIFAQVPNQELVAMG
YPAERLILACLFGAEPCNYRNFTPIFHPDYGNCYIFNWGMTEKALPSANPGTEFGLKLIL
DMGQEDYVPFLTSTAGARLMLHEQRSYPFIKEEGIYAMAGMETSIGVLVDKLQRKGEPYS
QCTKNGSDVPIQNLYSNYNTTYSIQACIRSCFQEHMIRECGCGHYLYPLPHKRKYCNNQE
FPDWAHCYSALRISLAQRETCIYACKESCNDTQYKMTISMAVWPSEASEDWIFHVLSQER
DQSSNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIE
FGEIIIDFVWITIIKLVALAKSVRQKRAQARYEGPPPTVAELVEAHTNFGFQPDLATPGP
DVEAYPHEQNPPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
|
| External Links |
|---|
| GenBank ID Protein
| AAI40685.1 |
| UniProtKB/Swiss-Prot ID
| A5D7U4 |
| UniProtKB/Swiss-Prot Entry Name
| SCNNB_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DAAA02057753 |
| GeneCard ID
| SCNN1B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
