| Identification |
|---|
| BMDB Protein ID
| BMDBP02264 |
| Secondary Accession Numbers
| None |
| Name
| Sodium channel protein |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated sodium channel activity |
| Specific Function
| Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
>6069 bp
ATGGCAGCCTTCCTGTTACCTCGGGGCACCAGCAGCTTCCGCAGGTTCACCCGGGAGTCT
CTGGCGGCCATCGAGAAGCGCATGGCAGAGAAGCAGGCCCGGAGCTCGGCCGCCTCGCAG
GAGAGCCGCGACGGGCTGCCCGAGGAGGAGGCGCCCCGGCCCCAGCTGGACCTGCAAGCC
TCCAAAAAGCTGCCGGATCTCTACGGCAACCCACCCCGAGAGCTCATCGGGGAGCCCCTG
GAGGACCTGGACCCCTTCTATAGCACTCAAAAGACCTTCATCGTCCTGAACAAAGGCAAG
ACCATCTTCCGGTTCAGCGCCACCAACGCCTTGCATGTCCTCAGCCCCTTCCACCCCATC
CGGAGAGTGGCTGTGAAGATCTTGGTGCATTCGCTCTTCAGCATGCTCATCATGTGTACC
ATTCTGACCAACTGCGTGTTCATGGCCCAGCACGACCCTCCGCCCTGGACCAAATATGTC
GAGTACATCTTCACTGCCATCTACACCTTTGAGTCTCTGGTCAAGATTCTGGCTCGAGGC
TTCTGCCTGCACGCGTTCACCTTCCTTCGGGACCCGTGGAACTGGCTGGACTTCAGCGTG
ATCATCATGGCATACACCACTGAATTTGTGGACCTGGGCAATGTCTCAGCTTTACGTACC
TTCCGAGTCCTCCGGGCCCTGAAAACTATATCAGTCATTTCAGGCCTGAAGACCATCGTG
GGGGCCCTGATCCAGTCTGTGAAGAAGCTGGCCGATGTGATGGTCCTCACGGTCTTCTGC
CTCAGCGTCTTCGCCCTCATCGGCCTTCAGCTCTTCATGGGCAACCTGAGGCACAAGTGC
GTCCGCAACTTCACGGTGCTCAACGGCACCAACAGCACCAATGCCTCCGTGGAGGCCGAC
GGCCTGATCTGGGCATCGCTGGACGACTACCTCAACGACCCAGAAAATTACCTACTCAAG
AATGGCACCTCTGACGTGTTACTGTGTGGGAACAGCTCCGACGCTGGGACATGTCCTGAG
GGCTACAGGTGCCTGAAGGCAGGTGGGAACCCTGACCATGGCTACACCAGCTTCGACTCC
TTCGCCTGGGCCTTCCTCGCACTCTTCCGACTGATGACGCAGGACTGCTGGGAGCGCCTC
TACCAGCAGACCCTGAGGTCTGCAGGGAAGATCTACATGATCTTCTTCATGCTGGTCATC
TTCCTGGGCTCCTTCTACTTGGTGAACTTGATCCTGGCTGTGGTCGCCATGGCCTACGAG
GAGCAAAACCAAGCCACCATCGCAGAGACAGAGGAGAAGGAAAAGCGATTCCAGGAAGCC
ATGGAGTTGCTCAAGAAAGAGCAGGAGGCCCTCGCCATCAGGGGTGTGGACACCGTGTCC
CGCAGCTCCTTGGAGATGTCCCCATTGGCCCCAGTAACCACCCACGAGAGAAGGAGCAAG
AGAAGAAAACGAATGTCTTCAGGGATGGAAGAGTGTGGGGACGACAAGTTCCCCAAGTCC
GACTCAGAGGATGGTCCCCGAGCAGTGAATCGTTTCAGCATCACCCATGGCCTCAGCAGG
ACCTCCATGAAGCCGCGCTCCAGCCACGGGAGCATTTTCACCTTCCGCCGACGGGACCTG
GGCTCCGAGACAGATTTTGCGGACGATGAAAACAGCACCGCCGGGGACAGTGAGAGCCAC
CGCACATCACTGCTGGTGCCTTGGCCCCTGCGGCGGCCTAGTACCCTGGGACAGCCCAGT
CCCGGAACCTCAACTCCCGGCCACGTGCTCAACGGCAAAAGGAACAGCACTGTGGACTGT
AACGGGGTGGTCTCCTTGCTGGGGGCAGGAGACCCCGAGGCCACCTCCCCAGGGAGTCAC
CTCCTCCACCCTATGAAGCTGGAGCGCCCCCCAGACACGACCACACCATCGGAGGAGCCG
GGCAGGCCCCAGACGCTGACGCCCCAGGCTCCGTGTGTAGACGGCTTCGAGGAGCCAGGA
GAGCGGCAGCGAGCCCTCAGTGCAGTGAGCGTCCTCACCAGTGCCCTGGAAGAGCTGGAG
GAGTCTCAGCGCAGGTGTCCACCGTGCTGGATCCGTTTTGCCCAGCACTACCTGATCTGG
GAGTGCTGCCCGCTGTGGATGTCCATTAAGCAGAAAGTGAAGTTCATGGTCATGGACCCA
TTTGCTGACCTCACCATCACCATGTGCATCGTGCTTAACACGCTCTTCATGGCACTGGAG
CACTACAACATGACGACCGAATTTGAGGAGATGCTGCAGGTTGGAAACCTGGTCTTCACA
GGAATATTCACAGCAGAGATGACCTTCAAGATCATTGCCTTGGACCCCTACTACTACTTC
CAGCAGGGCTGGAACATCTTCGACAGCATCATCGTCATCCTCAGCCTCATGGAGCTGGGC
CTGTCCCGCATGGGCAATCTGTCGGTGCTTCGCTCCTTCTGCCTGCTTCGGGTCTTCAAG
CTGGCCAAGTCCTGGCCCACCCTGAACACACTCATCAAGATCATTGGGAACTCAGTGGGC
GCGCTAGGCAACCTGACGTTGGTGCTGGCCATCATTGTGTTCATCTTCGCTGTGGTGGGC
ATGCAGCTCTTTGGCAAGAACTACTCAGAGCAGAGGCACCGTATCAGTGACTCGGGCCTC
CTGCCCCGCTGGCACATGATGGACTTCTTCCATGCCTTCCTCATCATCTTCCGCATCCTC
TGTGGAGAGTGGATCGAGACCATGTGGGACTGCATGGAGGTGTCTGGGCAGTCACTATGC
CTGCTGGTCTTCCTGCTTGTTATGGTCATTGGTAACCTCGTGGTCCTGAACCTCTTCCTG
GCTTTACTGCTCAGCTCCTTCAGCGCAGACAACCTCACAGCTCCCGACGAGGATGGGGAG
ATGAACAACCTCCAGCTGGCTCTGGCCCGCATCCAGCGAGGCCTGCGCTTCATCAAGCGG
ACCACCTGGGACTTCTGCTGCGTGCTCCTGCAGCGGCCGCCTCAGAAGCCCGCGGCCCTC
GCCTCCCAGGGCCAGCTGCCGGGCTGTATCGCCACCTCCAGCCCCCCACCCCAACCAGAG
AGCGAGAAGGCGCCCCCAGCCCGCAAGGAGACGCGGTTTGAGGAAGGCCAGCGGCCAGGT
CAGGGCGCACCTGGGGATGCCGAGCCTGTGTGTGTGCCCATCGCCGTGGCCGAGTCAGAC
ACGGATGACCCCGAGGAGGATGAGGAGAACAGCCTAAGCACAGAGGAAGAGTCCAGCAAG
CAGCAGGAATCCCAGCTGGCGTCCGGCAGCCCAGAGGCCCTCCCAGAGCCGAGGGTCTGG
AGCCAGGTGTCGGAGACCACCTCCTCTGGGGCCGAGGCCAGTGAGGTTCAGGCAGACTTG
CGGCAGCAGCGGCGAGCAGAGGCCCCCGCCCCAGGGTGCAGTGAGCTTCCCGAAGACAGT
TACTCTGAGGGGAGCACGGCAGATATGACCAACACTGCTGACCTCCTGGAGCAGATCCCT
GACCTCGGAGAGGATGTCAAAGATCCAGAGGACTGCTTCACTGAAGGCTGTGTCCGCCGC
TGTCCCTGCTGCACCGTGGACACCACACAGGCCCACGGGAAGGTCTGGTGGAGGCTGCGC
AAGACCTGCTACCGCATCGTGGAGCACAGCTGGTTCGAGACGTTCATCATCTTCATGATC
CTGCTCAGCAGTGGCGCACTGGCCTTTGAGGACATCTACCTGGAGGAGCGGAAGACCATC
AAGGTCCTGCTGGAGTACGCCGACAAGATGTTCACCTACGTCTTCGTGCTGGAGATGCTC
CTCAAGTGGGTGGCCTACGGCTTCAAGAAGTACTTCACCAACGCCTGGTGCTGGCTTGAT
TTCCTCATCGTGGACGTCTTGCTGATCAGCCTGGTGGCCAACGCCCTGGGCTTTGCTGAG
ATGGGCCCCATCAAGTCACTGCGGACCTTGCGTGCGCTCAGACCCCTGCGAGCCCTGTCA
CGATTTGAGGGCATGAGGGTTGTGGTTAACGCCCTGGTGGGCGCCATCCCATCCATCATG
AACGTCCTCCTCGTCTGCCTCATCTTCTGGCTCATCTTCAGCATCATGGGCGTGAACCTC
TTCGCGGGGAAGTTTGGGAGATGCATCAACCAGACCGAGGGAGACCTGCCCTTGAACTAT
ACCATCGTGAACAACAAGAGCGACTGTGAGTCTTTCAATGTGACTGGCGAATTGTACTGG
ACCAAGGTGAAGGTCAACTTTGACAACGTGGGGGCCGGGTACCTGGCCCTTCTGCAGGTG
GCAACATTTAAAGGCTGGATGGACATCATGTATGCAGCTGTAGACTCCAGGGGGTACGAG
GAGCAGCCCCAGTGGGAATACAACCTCTACATGTATATCTATTTTGTCATCTTCATCATC
TTTGGGTCTTTCTTCACCCTGAACCTGTTCATCGGTGTCATCATTGACAACTTCAACCAG
CAGAAGAAAAAGTTAGGGGGCCAGGACATCTTCATGACAGAGGAGCAGAAGAAGTACTAC
AACGCCATGAAGAAGCTGGGCTCCAAGAAGCCCCAGAAGCCCATCCCACGGCCCCTGAAC
AAGTACCAGGGCTTCATATTCGACATTGTGACCAAGCAGGCCTTCGACGTCACCATCATG
TTTCTCATCTGCTTAAACATGGTGACCATGATGGTGGAGACAGACGACCAGAGCCCCGAG
AAGGTCAACATCTTGGCCAAGATCAACCTGCTGTTCGTGGGCATCTTCACAGCCGAGTGT
ATCTTCAAGATGGTTGCCCTGCGCCACTATTACTTCACCAACAGCTGGAACATCTTCGAC
TTCGTGGTTGTCATCCTCTCCATCGTAGGCACTGTGCTCTCAGACATCATCCAGAAGTAC
TTCTTCTCCCCGACGCTCTTCCGCGTCATCCGCCTGGCCCGCATCAGCCGCATCCTCAGG
CTGATCCGCGGGGCCAAGGGCATCCGCACGCTTCTCTTCGCCCTCATGATGTCCCTGCCC
GCGCTCTTCAACATCGGGCTGCTGCTCTTCCTCGTCATGTTCATCTACTCCATCTTCGGC
ATGGCCAACTTCGCCTACGTCAAGTGGGAGGCTGGCATCGACGACATGTTCAACTTCCAG
ACCTTCGCCAACAGCATGCTGTGCCTCTTCCAGATCACCACGTCGGCGGGCTGGGATGGG
CTCCTCAGCCCCATCCTCAACACGGGGCCCCCCTACTGCGACCCCAACCTGCCCAACAGC
AACGGCTCCCGGGGCAACTGCGGGAGCCCCGCGGTGGGCATCCTCTTCTTCACCACCTAC
ATCATCATCTCCTTCCTCATTGTGGTCAACATGTACATCGCCATCATCCTGGAGAACTTC
AGCGTGGCCACGGAGGAGAGCACGGAGCCCCTGAGTGAGGATGACTTCGACATGTTCTAC
GAGATCTGGGAGAAGTTCGACCCGGAGGCCACCCAGTTCATCGAGTATTTGGCCCTGTCT
GACTTCGCCGATGCCCTGTCAGAGCCACTCCGGATCCCCAAGCCCAACCAGATAAGCCTC
ATCAATATGGACCTGCCCATGGTGAGTGGAGACCGCATCCACTGCATGGACATCCTCTTT
GCCTTCACCAAGAGGGTCCTGGGCGAATCTGGGGAGATGGACGCCCTGAAGATCCAGATG
GAGGAGAAGTTCATGGCGGCCAACCCGTCCAAGATCTCCTACGAGCCCATCACCACCACG
CTGCGGCGGAAGCACGAGGAGGTGTCGGCCACGATCATCCAGCGGGCCTTCCGCCGGCAC
CTGCTGCAGCGCTCCGTCAAGCACGCCTCCTTCCTCTACCGCCAGCAGGCGGGCAGCAGC
GGCCTCTCGGAGGAGGACGCCCCCGAGCAGGAGGGCCTCATCGCCTACATGATGAACGAG
AACTTCTCCCGCCGCCCCGGCCCGCCCTCCAGCTCCTCCGTCTCCTCCACGTCCTTCCCG
CCCTCCTACGACAGCGTCACCAGGGCCACCAGCGACAACCCCCAGGTGCGGGCGTCTGAC
TACAGCCCAAGCGAGGATCTCGCCGACTTCCCCCCAACCCCCGACAGGGACCGTGAGTCA
ATCGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2022 |
| Molecular Weight
| 227894.0 |
| Theoretical pI
| 5.23 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 127-147
- 159-178
- 230-247
- 253-273
- 391-419
- 721-739
- 751-772
- 784-801
- 841-864
- 884-901
- 921-944
- 1210-1229
- 1250-1266
- 1278-1299
- 1327-1353
- 1449-1475
- 1534-1552
- 1564-1586
- 1598-1614
- 1651-1679
- 1754-1777
|
| Protein Sequence
|
>Voltage-gated sodium channel alpha subunit
MAAFLLPRGTSSFRRFTRESLAAIEKRMAEKQARSSAASQESRDGLPEEEAPRPQLDLQA
SKKLPDLYGNPPRELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALHVLSPFHPI
RRVAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYIFTAIYTFESLVKILARG
FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTVLNGTNSTNASVEAD
GLIWASLDDYLNDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGGNPDHGYTSFDS
FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE
EQNQATIAETEEKEKRFQEAMELLKKEQEALAIRGVDTVSRSSLEMSPLAPVTTHERRSK
RRKRMSSGMEECGDDKFPKSDSEDGPRAVNRFSITHGLSRTSMKPRSSHGSIFTFRRRDL
GSETDFADDENSTAGDSESHRTSLLVPWPLRRPSTLGQPSPGTSTPGHVLNGKRNSTVDC
NGVVSLLGAGDPEATSPGSHLLHPMKLERPPDTTTPSEEPGRPQTLTPQAPCVDGFEEPG
ERQRALSAVSVLTSALEELEESQRRCPPCWIRFAQHYLIWECCPLWMSIKQKVKFMVMDP
FADLTITMCIVLNTLFMALEHYNMTTEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF
QQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFCLLRVFKLAKSWPTLNTLIKIIGNSVG
ALGNLTLVLAIIVFIFAVVGMQLFGKNYSEQRHRISDSGLLPRWHMMDFFHAFLIIFRIL
CGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGE
MNNLQLALARIQRGLRFIKRTTWDFCCVLLQRPPQKPAALASQGQLPGCIATSSPPPQPE
SEKAPPARKETRFEEGQRPGQGAPGDAEPVCVPIAVAESDTDDPEEDEENSLSTEEESSK
QQESQLASGSPEALPEPRVWSQVSETTSSGAEASEVQADLRQQRRAEAPAPGCSELPEDS
YSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCTVDTTQAHGKVWWRLR
KTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEML
LKWVAYGFKKYFTNAWCWLDFLIVDVLLISLVANALGFAEMGPIKSLRTLRALRPLRALS
RFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNY
TIVNNKSDCESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYE
EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYY
NAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPE
KVNILAKINLLFVGIFTAECIFKMVALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKY
FFSPTLFRVIRLARISRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG
MANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNS
NGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFY
EIWEKFDPEATQFIEYLALSDFADALSEPLRIPKPNQISLINMDLPMVSGDRIHCMDILF
AFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATIIQRAFRRH
LLQRSVKHASFLYRQQAGSSGLSEEDAPEQEGLIAYMMNENFSRRPGPPSSSSVSSTSFP
PSYDSVTRATSDNPQVRASDYSPSEDLADFPPTPDRDRESIV
|
| External Links |
|---|
| GenBank ID Protein
| CAC80974.1 |
| UniProtKB/Swiss-Prot ID
| Q8WMP8 |
| UniProtKB/Swiss-Prot Entry Name
| Q8WMP8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ251721 |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
