| Identification |
|---|
| BMDB Protein ID
| BMDBP02275 |
| Secondary Accession Numbers
| None |
| Name
| Sodium-coupled monocarboxylate transporter 2 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC5A12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). |
| Pathways
|
- Thyroid Hormone Synthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| SLC5A12 |
| Gene Sequence
|
>1854 bp
ATGGAGGTGAAGAACTTTGCAGTTTGGGATTATGTTGTCTTTGCAGCCCTCTTCATCATT
TCCTCTGGAATTGGGGTGTTCTATGCGATTAAGGAGAGAAAAAAAGCAACTTCGAGGGAG
TTTCTGGTCGGTGGCCGGCAAATGAGCTTTGGCCCAGTGGCATTATCCCTGACAGCCAGC
TTCATGTCCGCCGTCACTGTCCTGGGGACCCCTGCCGACGTCTACCGCTTTGGAGCATCC
TTCGTCCTCTTCTTCATCACGTACGGGTTAGTCATTATCCTCACGTCAGAGCTCTTTCTT
CCTGTGTTCTACAGATCTGGCATCACCAGCACGTACGAGTACTTACAACTACGATTCAAC
AAACCAGTTCGCTATGCAGCCACAGTCATCTACATCGTGCAAACGATTCTCTACACGGGA
GTGGTGGTGTACGCTCCTGCTCTGGCCCTCAATCAAGTGACTGGGTTTGATCTCTGGGGC
TCTGTGTTTGCAACGGGAATCGTTTGCACATTCTACTGTACCCTGGGAGGATTAAAAGCA
GTAGTGTGGACAGATGCATTTCAGATGGTTGTCATGATCGTGGGCTTCTTAACGGTTCTC
ATTCAAGGATCAACCTATGCTGGTGGATTACACAATGTATTAGAACAAGCAGAAAATGGA
TCTCGATTAAATATATTTGACTTTGATATAGATCCTCTCAGGAGGCACACTTTTTGGACA
ATCTCAGTGGGAGGAACCTTTACGTGGCTTGGGATCTATGGAGTTAATCAGTCGACCATC
CAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCCAAGCTAGCCTTGTACTTCAACTTG
CTAGGTCTCTGGATCATTCTGCTATGTGCAGTCTTTTCTGGTTTAACCATGTACGCGCAC
TTCAAAGACTGTGATCCTTGGACTTCGGGCATCATCTCAGCCCCAGACCAGCTGATGCCA
TACTTCGTCATGGAGTTATTTTCCACGATGCCTGGACTTCCAGGACTTTTCGTGGCTTGT
GCCTTCAGTGGAACTTTGAGCACCGTGGCTGCCAGCATCAATGCCTTAGCAACAGTGACC
TTTGAGGATTTTGTCAAGAGCTGTTTTCCTCGTCTCTCTGACAAGCTGAGCACCTGGATC
AGTAAAGGCTTATGTCTTTTATTTGGCGTGATATGTACCTCCACAGCTGTGGCTGCATCC
CTCATGGGTGGTGTCATACAGGCTGCCCTCAGTATCCACGGCATGTGTGGGGGGCCGATG
CTGGGCTTGTTCTCTCTGGGAATTCTGTTCCCTTTTGTGAACTGGAAGGGTGCCCTAGCA
GGCCTTCTGACCGGAATCCTCTTGTCATTTTGGGTGGCCATCGGGGCCTTCATTTACCCT
GCACCAGCCTCTAAGACGTGGCCTTTGCCTTTGTCGACTGACCAGTGTGGCCTATCAAAC
GTGACGGAATCGGTGCCTCCGGTGCTGTCCAGCAGACCCGCCATCGCTGAGACCTGGTAT
GCCCTCTCCTACCTGCACTACAGCACCGTGGGCTGCCTGGGATGCATAGCTGCTGGAGTA
ATCATCAGCTTCCTAACAGGTCTCCAAAAGGGCAAGGATATTCCACCACTGCTAATTAGA
CCAGTCTGCAATTTATTTTGCTTTTGGTCTAAGAAATACAAAACACTGTGCTGGTGTGGA
GTTCAGCATGACAGTGGAACAGAGCAGGAAAACCTTGAGAATGACAGTACCTGGAAACAA
GGAGCTGAATCTGTCTTACAAAACGGCCTCAAGCAAGAAAGCCTGGTTCCAGGCTACGAT
CCCAAGGACAAAAGCTATGACAACATGGCTTTAGAGAAGATTACCCATTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 617 |
| Molecular Weight
| 67410.0 |
| Theoretical pI
| 7.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-26
- 48-68
- 81-101
- 129-149
- 158-178
- 181-201
- 236-256
- 274-294
- 335-357
- 386-406
- 412-432
- 438-458
- 508-528
|
| Protein Sequence
|
>Sodium-coupled monocarboxylate transporter 2
MEVKNFAVWDYVVFAALFIISSGIGVFYAIKERKKATSREFLVGGRQMSFGPVALSLTAS
FMSAVTVLGTPADVYRFGASFVLFFITYGLVIILTSELFLPVFYRSGITSTYEYLQLRFN
KPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKA
VVWTDAFQMVVMIVGFLTVLIQGSTYAGGLHNVLEQAENGSRLNIFDFDIDPLRRHTFWT
ISVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILLCAVFSGLTMYAH
FKDCDPWTSGIISAPDQLMPYFVMELFSTMPGLPGLFVACAFSGTLSTVAASINALATVT
FEDFVKSCFPRLSDKLSTWISKGLCLLFGVICTSTAVAASLMGGVIQAALSIHGMCGGPM
LGLFSLGILFPFVNWKGALAGLLTGILLSFWVAIGAFIYPAPASKTWPLPLSTDQCGLSN
VTESVPPVLSSRPAIAETWYALSYLHYSTVGCLGCIAAGVIISFLTGLQKGKDIPPLLIR
PVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENDSTWKQGAESVLQNGLKQESLVPGYD
PKDKSYDNMALEKITHF
|
| External Links |
|---|
| GenBank ID Protein
| AAI51503.1 |
| UniProtKB/Swiss-Prot ID
| A7MBD8 |
| UniProtKB/Swiss-Prot Entry Name
| SC5AC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151502 |
| GeneCard ID
| SLC5A12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
