| Identification |
|---|
| BMDB Protein ID
| BMDBP02278 |
| Secondary Accession Numbers
| None |
| Name
| Sodium/potassium/calcium exchanger 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC24A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| SLC24A1 |
| Gene Sequence
|
>3600 bp
ATGGGGAAACTGATCAGGATGGGGGCACAGGAGAGGCGGTCACTCTGGCCAAAGCGACTT
CATTGGAGTCGCCCCCTCTTCCTATTGGGAATGTTGATCATAGGTTCCACCTACCAGTAC
CTGACGAGCCCTCAGGGCCTCCCCACACTGTGGGCAGCAGTCTCTTCCCAACACCCTGTA
AAAGTAGCCAGCCGGGACCTTTCCAACAAGGAGATGATGATGGTGAGCAGTGAGACTTCA
AAATCTAGCTCTGAAATGGAGGTTGAGGCATGGGCACCGGAAGCCACAGCAGGCAGAGAT
GGAACACCACCTGGCATAGCCAGGAAGAACACCCCCAGTACACCTAGAGGAACAGCCAGC
ATCACTCCAGCAATACCCAATAACTACAGCCCAACACCAACAGGCACAGGAAAAGTTAAG
GAAGACACCTCAGCCACACCCAGTGGAGTACTGAATCACTACACTCAAAGCAGACCAATG
GTAAATAGTTATACCCGCTTGACAGCCAGGGGAGAAGTAAAGAGCTCCCGCCCAACTCAA
TCCAGGGGAAAGGAGGAGAAATACTCCCCATCCCCACTTGGTAGAATGGTAAACAGTTAT
GCCCCATCCACACTCATGACAATGCCAAGGAGCCATGGCATCACCCCCAGAACAACAGTG
AAAGACAGAGAAATTATGGCGACCAAGAAAATGTTGGCGACCAACCCATCCAAGAGACTA
GTGGAGAAAACCACCCCAACTCCTCTCAAGGGAATAACTGATAACACCCCAACCTTCCTG
TTAAGTGACTTAGAAACAGACACCTTGACTTCTCCAAGAAATGTGGTAGAAAAGAAGACC
CTAACTACCCCCAGAAGAGTGGACAGTAATAGCTCAACCAACCACCAGGGGTTGGTGGGG
AAAAACAATCTGACAACACCCCAAGGAATGGTCCTGGAGCACACTGCGGCCGTCTCTGAG
GGGCAAGTGACAATAAGCACCATGACACGCAGCAGCCCAACAGAAACCAAAGCTTCTACT
GATGCTTGGAAAGTCAGGAATCCCTTGCCCAGAACCAGTGCACCGATCATCAGAATATCC
TCAGCCACCTTCAGGGGGCTTTTGAAAAACCCTTCCAAAGCACCCAGCACCCCAGCAGCT
CCCAGGGTTAGGGCAAATCCGACCATTCAGGTCCGCCACTGCCTGGTGGTGGAGCCAGCC
CCAGTTGCACCCACTGCCCCCTCCCCTAGTTGGACAACAGCTGTGATCCCAGGGATTCCT
AGTCCCTCAGGACAGCCAGACCTGTACCCCAAGGCAGAGTACCCCCGAGACCTGTTCAGT
GTGGAGGAGCGGAGGCAGGGCTGGGTGGTCCTGCACATCTTTGGCATGATGTATGTGTTT
GTAGCCTTGGCCATCGTTTGTGACGAGTACTTTGTCCCTGCCCTGGGCGTCATCACAGAC
AAGCTGCAGATCTCTGAGGATGTGGCAGGCGCTACATTCATGGCTGCTGGAGGCTCTGCC
CCCGAGCTCTTCACCTCCCTCATCGGCGTCTTCATCTCCCATAGCAACGTGGGCATTGGC
ACCATAGTGGGCTCTGCGGTGTTCAACATCCTCTTTGTCATTGGCACTTGTGCCCTCTTC
TCCCGGGAGATCCTCAACCTCACCTGGTGGCCCTTGTTCCGAGACATCACCTTCTACATC
TTTGACCTAATGATGCTCATCCTCTTCTTCCTGGATAGCCTCATTGCGTGGTGGGAGAGC
GTGCTCCTGCTGCTGGCTTATGCCTTCTATGTGTTCACCATGAAGTGGAACCAACAGCTC
GAGCTCTGGGTGAAAGAGCAGCTCAACAAGAGGCCAGTGGCCAAGGTCATGGCCCTAGGG
GACCTCAGCAAGCCGGGCGATGGGACAGTTGTGGTGGATGAGCAGCAGGATAACAAGAAG
CTGAAGCTTTCATCCATGCTGACCCGAGGGAGCAGCTCGGCCTCTCTGCACAACAGCACC
ATCCGCAGCACCATCTACCAGCTCATGCTCCACAGCCTGGACCCTCTGGGGGAAGCCCGG
CCCTCCAAGGACAAGGAGGAGGAGACCTTGATTCCGGAGGCAAAAGCCACGCCTCAGGCC
AAAGCAGAGAGCAAACCAGAGGAGGAGCCGGCCAAGCTCCCTGAGGTCACGGTCACACCA
GCCCCTGCTCCAGACGTCAAGGGAGATCAGGAGGAGGATCCTGGCAGTCAGGGAGTCGGG
GCCGAAGCTGAGAACACAGGTGAAAGGACAGGTGGAGAGGCGGAAGCTCCTGCTGAAGGT
GAAAACGGAGAGCGAAGTGGAGGCGACGCTGCATTAGGAGGTGAAAGTGAAGGAAAAGCA
GAGAATGAAAGTGAAGGTGACATCCCGGCAGAAAGGAGAGGAGATGATGAAGACGAAGGT
GAAATCCAGGCAGAAGGTGGTGAAGTGAAAGGTGATGAAGACGAAGGTGAAATCCAGGCA
GGAGAAGGTGGGGAAGTGGAAGGTGATGAAGACGAAGGTGAAATCCAGGCAGGAGAAGGT
GGGGAAGTGGAAGGTGATGAAGACGAAGGTGAAATCCAGGCAGGAGAAGCTGGGGAAGTG
GAAGGTGATGAAGACGAAGGTGAAATCCAGGCAGGAGAAGCTGGGGAAGTGGAAGGTGAT
GAAGACGAAGGTGAAATCCAGGCAGGAGAAGGTGGTGAAGTGAAAGGTGATGAAGGTGAA
ATCCAGGCAGGAGAAGCTGGGGAAGTGGAAGGAGAGGATGGTGAAGTGGAAGGTGGTGAA
GATGAAGGTGAAATCCAGGCAGGAGAAGGTGGTGAAGGTGAAACTGGAGAGCAGGAATTG
AATGCTGAAATTCAAGGTGAAGCCAAAGATGACGAGGAAGGTGTGGATGGTGAAGGGGGA
GGTGATGGAGGTGACAGTGAAGATGAAGAAGAGGAAGATGAAGAAGAGGAAGACGAAGAA
GAGGAAGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAAATGAACAGCCTTTGTCCCTGGAA
TGGCCTGAGACCAGGCGGAAGCAAGCCATTTACCTCTTTCTCCTGCCCATTGTGTTCCCG
CTGTGGCTGACGGTTCCCGACGTCCGGAGGCTGGAGGCTAAGAAGTTTTTTGTTATCACC
TTCCTGGGATCCATCCTGTGGATAGCCATGTTCTCATACCTCATGGTTTGGTGGGCTCAC
CAGGTTGGCGAAACAATAGGGATTTCTGAAGAGATCATGGGTTTGACGATCCTAGCAGCA
GGCACATCAATTCCTGACCTCATCACCAGTGTGATTGTCGCTCGGAAAGGCCTGGGTGAC
ATGGCTGTGTCAAGCTCCGTGGGCAGTAACATATTTGATATCACCGTGGGCCTGCCCCTT
CCTTGGATGCTTTTCTCTCTCATCAATGGATTGCAGCCTGTTGCTGTCAGTAGCAATGGC
TTGTTCTGTGCAATTGTTTTGCTTTTTCTCATGCTCCTGTTTGTGATCTCGTCAATTGCA
TTATGCAAGTGGAGAATGAACAAGATCCTGGGCTTCACCATGTTCCTCCTGTACTTTGTA
TTCCTGATAATCAGTGTGATGCTGGAAGATCGAATCATATCCTGCCCTGTATCTGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1216 |
| Molecular Weight
| 131614.0 |
| Theoretical pI
| 4.13 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 447-467
- 492-512
- 519-539
- 558-578
- 580-600
- 1025-1045
- 1053-1073
- 1089-1109
- 1128-1148
- 1158-1178
- 1186-1206
|
| Protein Sequence
|
>Sodium/potassium/calcium exchanger 1
MGKLIRMGAQERRSLWPKRLHWSRPLFLLGMLIIGSTYQYLTSPQGLPTLWAAVSSQHPV
KVASRDLSNKEMMMVSSETSKSSSEMEVEAWAPEATAGRDGTPPGIARKNTPSTPRGTAS
ITPAIPNNYSPTPTGTGKVKEDTSATPSGVLNHYTQSRPMVNSYTRLTARGEVKSSRPTQ
SRGKEEKYSPSPLGRMVNSYAPSTLMTMPRSHGITPRTTVKDREIMATKKMLATNPSKRL
VEKTTPTPLKGITDNTPTFLLSDLETDTLTSPRNVVEKKTLTTPRRVDSNSSTNHQGLVG
KNNLTTPQGMVLEHTAAVSEGQVTISTMTRSSPTETKASTDAWKVRNPLPRTSAPIIRIS
SATFRGLLKNPSKAPSTPAAPRVRANPTIQVRHCLVVEPAPVAPTAPSPSWTTAVIPGIP
SPSGQPDLYPKAEYPRDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITD
KLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALF
SREILNLTWWPLFRDITFYIFDLMMLILFFLDSLIAWWESVLLLLAYAFYVFTMKWNQQL
ELWVKEQLNKRPVAKVMALGDLSKPGDGTVVVDEQQDNKKLKLSSMLTRGSSSASLHNST
IRSTIYQLMLHSLDPLGEARPSKDKEEETLIPEAKATPQAKAESKPEEEPAKLPEVTVTP
APAPDVKGDQEEDPGSQGVGAEAENTGERTGGEAEAPAEGENGERSGGDAALGGESEGKA
ENESEGDIPAERRGDDEDEGEIQAEGGEVKGDEDEGEIQAGEGGEVEGDEDEGEIQAGEG
GEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDE
GEIQAGEGGEVKGDEGEIQAGEAGEVEGEDGEVEGGEDEGEIQAGEGGEGETGEQELNAE
IQGEAKDDEEGVDGEGGGDGGDSEDEEEEDEEEEDEEEEEEEEEEEEEENEQPLSLEWPE
TRRKQAIYLFLLPIVFPLWLTVPDVRRLEAKKFFVITFLGSILWIAMFSYLMVWWAHQVG
ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWM
LFSLINGLQPVAVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLI
ISVMLEDRIISCPVSV
|
| External Links |
|---|
| GenBank ID Protein
| CAA47108.1 |
| UniProtKB/Swiss-Prot ID
| Q28139 |
| UniProtKB/Swiss-Prot Entry Name
| NCKX1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X66481 |
| GeneCard ID
| SLC24A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
