Identification
BMDB Protein ID BMDBP02307
Secondary Accession Numbers None
Name Differentially expressed in FDCP 8 homolog
Synonyms Not Available
Gene Name DEF8
Protein Type Enzyme
Biological Properties
General Function Involved in diacylglycerol binding
Specific Function Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 18
Locus Not Available
SNPs DEF8
Gene Sequence
>1344 bp
ATGGAATATGACGAGAAGCTCGCCCGGTTCCGGCAGGTCCATCTCAACCCCTTCAACAAG
CAGCAGCATGAGCAGGGGGCTGGCGAGGAGGCCCCGGGCATTACTTCTCAAGCACGCCTG
CCTGAGCTGCCTCCCGGGGAACCAGAGTTCCGCTGCCCAGAGCGTGTGATGGATCTTGGC
CTGTCTGAGGACCACTTCGCTCGCCCCGTGGGCCTGTTCCTGGCGTCTGATGTCCAGCAG
CTGCGGCAGGCCATCCAGGAGTGCAAGCAGGTCATCCTGGACCTTCCAGAGCACTCAGAG
AAGCAGAAGGACGCCGTGGTGAGACTCATCCATCTCCGGCTGAAGCTTCAGGAGCTGAAG
GACCCCAATGAGGATGAGCCCAACATTCGAGTCCTTCTCGAGCACCGCTTCTACAAGGAG
AAGAGCAAGAGTGTGAAGCAGACATGTGACAAGTGTAACACAGTCATCTGGGGCCTCATT
CAGACCTGGTACACCTGCACAGGGTGTTATTACCGCTGTCACAGCAAGTGTTTGAACCTC
ATCTCCAAGCCCTGTGTGCGGTCCAAAGTCAGCCACCAGGCCGAGTATGAGCTGAACATC
TGCCCTGAGGCAGGCTTGGACAGCCAGGATTACCGCTGTGCGGAGTGCCGAGCACCCATC
TCTCTGCGGGGCGTGCCCAGCGAGGCCCGGCAGTGCGACTACACTGGCCAGTACTACTGC
AGTCACTGCCACTGGAACGATCTGGCTGTCATCCCAGCGCGTGTGGTGCACAACTGGGAC
TTCGAGCCGCGCAAGGTGTCCCGTGGCAGCATGCGCTACCTGGCGTTGATGATGTCGAGG
CCAGTGCTCCGGCTCCGGGAGATCAATCCTCTGCTGTTCAACTATGTGGAGGAGCTGGTA
GAGATCCGGAAGCTGCGCCAGGATATCTTGCTCATGAAGCCATATTTTATCACCTGCAGG
GAGGCCATGGCAGCGCGCCTGCTCCTGCAGCTCCAGGACCGGCAGCACTTTGTGGAGAAC
GATGAGATGTACTCGGTGCAGGACCTGCTGGACACGCACACGGGCCGGCTGGGCTGCTCA
CTGGCTGAGACCCACACGCTGTTTGCCAAGCACATCAAACTGGACTGTGAGCGGTGCCAG
GCCAAGGGCTTTGTGTGCGAGCTCTGCCGGGAGGGAGATGTGCTATTCCCCTTCGACAGC
CACACATCCGTGTGCGCCGACTGCTCTGCTGTCTTCCACAGGGACTGCTACTACGACAAT
TCCACCACATGCCCTAGGTGTGCGCGCCTCACCCTGCGGAAGCAGTCGCTCTTCCGGGAG
CCTGGTCCAGACCTGGACGCCTGA
Protein Properties
Number of Residues 447
Molecular Weight 51847.0
Theoretical pI 6.93
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 31-52
  • 72-92
Protein Sequence
>Differentially expressed in FDCP 8 homolog
MEYDEKLARFRQVHLNPFNKQQHEQGAGEEAPGITSQARLPELPPGEPEFRCPERVMDLG
LSEDHFARPVGLFLASDVQQLRQAIQECKQVILDLPEHSEKQKDAVVRLIHLRLKLQELK
DPNEDEPNIRVLLEHRFYKEKSKSVKQTCDKCNTVIWGLIQTWYTCTGCYYRCHSKCLNL
ISKPCVRSKVSHQAEYELNICPEAGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYC
SHCHWNDLAVIPARVVHNWDFEPRKVSRGSMRYLALMMSRPVLRLREINPLLFNYVEELV
EIRKLRQDILLMKPYFITCREAMAARLLLQLQDRQHFVENDEMYSVQDLLDTHTGRLGCS
LAETHTLFAKHIKLDCERCQAKGFVCELCREGDVLFPFDSHTSVCADCSAVFHRDCYYDN
STTCPRCARLTLRKQSLFREPGPDLDA
GenBank ID Protein AAI42175.1
UniProtKB/Swiss-Prot ID A5PJM7
UniProtKB/Swiss-Prot Entry Name DEFI8_BOVIN
PDB IDs Not Available
GenBank Gene ID BC142174
GeneCard ID DEF8
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available