| Identification |
|---|
| BMDB Protein ID
| BMDBP02399 |
| Secondary Accession Numbers
| None |
| Name
| DnaJ homolog subfamily A member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| DNAJA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| DNAJA1 |
| Gene Sequence
|
>1194 bp
ATGGTGAAAGAAACCACTTACTATGATGTTTTGGGGGTCAAACCCAATGCCACCCAAGAA
GAATTGAAAAAGGCTTACAGGAAACTGGCCTTGAAGTACCACCCTGATAAGAATCCAAAT
GAAGGCGAGAAGTTTAAACAGATTTCTCAAGCTTACGAAGTGCTCTCTGATGCAAAGAAA
AGGGAGTTATATGACAAAGGAGGAGAACAGGCAATTAAAGAAGGTGGAGCAGGTGGTGGT
TTTGGCTCCCCCATGGACATCTTTGATATGTTTTTCGGAGGAGGAGGCAGGATGCACAGA
GAGAGGAGAGGTAAAAACGTTGTCCATCAACTTACAGTAACTTTAGAAGATTTATATAAT
GGTGCAACAAGAAAACTAGCTCTGCAAAAGAATGTGATTTGTGACAAATGTGAAGGCCGA
GGTGGTAAAAAAGGAGCAGTAGAATGCTGTCCCAATTGCCGAGGTACTGGAATGCAAATA
AGAATTCATCAGATAGGACCTGGAATGGTTCAGCAAATTCAGTCTGTCTGCATGGAGTGC
CATTGTCATGGGGAGCGGATCACCCCTAAAGATAGATGTAAAAGCTGCAATGGAAGGAAG
ATAGTTCGAGAAAAGAAAATTCTAGAAGTTCATATTGACAAAGGCATGAAAGATGGCCAG
AAGATAACATTCCATGGTGAAGGAGACCAAGAACCAGGACTGGAGCCGGGAGATATTATC
ATTGTTTTAGATCAGAAGGACCATGCTGTTTTTACTCGACGAGGAGAAGACCTTTTCATG
TGTATGGACATACAGCTGGTTGAGGCATTGTGTGGCTTCCAAAAGCCAATATCTACTCTT
GACAACCGAACCATAGTCATCACTTCTCATCCAGGTCAAATTGTCAAGCATGGAGATATC
AAGTGTGTGCTAAATGAAGGCATGCCAATTTATCGTAGGCCATACGAAAAGGGTCGCCTA
ATCATTGAATTTAAGGTAAACTTTCCTGAGAATGGCTTTCTCTCTCCTGATAAACTCTCT
TTGCTGGAAAAACTTCTGCCTGAGAGGAAGGAAGTAGAAGAGACTGATGAAATGGACCAG
GTAGAATTAGTGGACTTTGATCCAAATCAGGAAAGACGGCGCCATTACAATGGAGAAGCA
TACGAGGATGATGAACATCATCCTCGGGGTGGTGTTCAGTGTCAGACCTCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 397 |
| Molecular Weight
| 44882.0 |
| Theoretical pI
| 7.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DnaJ homolog subfamily A member 1
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKK
RELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLTVTLEDLYN
GATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMEC
QGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDII
IVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDI
KCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQ
VELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
|
| External Links |
|---|
| GenBank ID Protein
| AAX09083.1 |
| UniProtKB/Swiss-Prot ID
| Q5E954 |
| UniProtKB/Swiss-Prot Entry Name
| DNJA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021066 |
| GeneCard ID
| DNAJA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
