| Identification |
|---|
| BMDB Protein ID
| BMDBP02401 |
| Secondary Accession Numbers
| None |
| Name
| E3 ubiquitin-protein ligase UHRF1 |
| Synonyms
|
Not Available
|
| Gene Name
| UHRF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Defense mechanisms |
| Specific Function
| Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair (By similarity). |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| UHRF1 |
| Gene Sequence
|
>2361 bp
ATGTGGATCCAGGTTCGCACCATGGATGGGAAGGTAGCCCACACCGTGGACTCCTTGTCC
AGGCTGACCAAGGTGGAGGAGCTGAGAAAGAAGATCCAGGAGCTATTCCACGTGGAGCCA
GGCCTGCAGAGGCTTTTCTACCGGGGCAAGCAGATGGAGGACGGCCACACGCTGTTTGAC
TACGACGTCCGCCTGAACGACACCATCCAGCTCCTGGTCCGGCAGAGCCTTGTGCTGCCC
GTCCCTGTTCCCAGCAGCAGCGGTGGCAGCAAGGAGAGGGACTCTGAGCTCTCGGACACA
GACTCTGGCTGCGGCCTGGCCCAGAGCGAGTCGGACAAGTCCTCCAACAGCGGCGAGGCT
GCCAACGAGCCAGAAGGGAAGGCAGATGAGGACGAGTGTGATGAGACAGAGCTGGGCCTC
TACAAGGTCGGCGAGTACGTGGACGCGAGGGACACGAATATGGGCGCGTGGTTCGAGGCC
AAGGTCATCAGGGTGACAAGGAAGGCTCCGGCTCATGACCAGCCCAGCAGCTCCAGCTCA
AAGCCAGAGGACGACATCATCTATCACGTGACATACGATGACTACCCAGAGAACGGAGTG
GTCCAGATGACCTCACAGAACGTCCGGGCTCGAGCCCGACACACCATCAAGTGGGAGGAC
CTGCAGGTGGGCCAGGTGGTCATGGTCAACTACAACCCAGACCTCCCCAAGGACCGCGGT
TTCTGGTACGACGCCGAGATCCTGAGGAAACGCGAGACCAGGACAGCGCGGGAGCTGCAT
GCCAACGTCAGGATCGGGGGTGATTCTCTCAATGACTGTCGGATTGTCTTCGTGGATGAA
GTTTTCAAGATCGAGCGTCCGGGCGAGGGGAACCCCATGGTGGAAAACCCGATGAGAAGG
AAGAGCGGGCCCTCCTGCAAGCACTGTAAGGACGATGAGCGGAAGCTGTGCCGCATGTGC
GCCTGCCACGTGTGCGGGGGCAAGCAGGACCCTGACAAGCAGCTGATGTGCGACGAGTGC
GACATGGCCTTCCACATCTACTGCCTGCGCCCACCGCTCAGCAGCGTGCCCCCTGAGGAG
GAGTGGTACTGCCCTGACTGCCGGATCGACTCCAGTGAGGTGGTGCAGGCGGGTGAGAAG
CTGAAGGAGAGTAAGAAGAAGGCGAAGATGGCGTCGGCCACATCGTCCTCGCAGCGGGAC
TGGGGCAAGGGCATGGCGTGCGTGGGCCGCACCAAGGAGTGCACCATTGTGCCGTCCAAT
CACTTTGGCCCCATCCCGGGCATTCCTGTGGGCACCATGTGGAGGTTCCGAGTCCAGGTC
AGCGAGTCGGGGGTCCATCGACCTCACGTGGCGGGTATCCATGGCCGGAGCAATCACGGG
GCCTACTCCTTGGTCCTGGCTGGAGGGTATGAGGACGATGTGGACCATGGGAACTCGTTC
ACGTACACAGGTAGTGGCGGACGAGACCTTTCCGGAAACAAGCGGACTGCGGAACAGTCT
TGTGATCAGAAACTCACCAACACCAACAGGGCTCTGGCTCTCAACTGCTTTGCCCCCATC
AACGACCTCAAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCAGTCCGCGTGGTG
CGGAACGTCAAGGGCCGCAAGCACAGCAAGTATGCGCCCATCGAGGGCAACCGGTACGAC
GGCATCTATAAGGTTGTCAGGTACTGGCCCGAGAAGGGCAAGTCCGGCTTCCTGGTGTGG
CGCTTCCTCCTACGTCGAGATGACGTGGAGCCGGGACCCTGGACCAAGGAGGGCAAGGAC
CGGATCAAGAAGCTGGGGCTGACCATGCAGTATCCCGAGGGCTACCTGGAGGCCCTGGCC
AGAAAGGAGAAGGAGAACAGCAAGCAGGCAGCCCTGGACAAGGAGGAGGAGGATGGGGAG
GAGGGCTTCACATCCCCCAGGAAGGGCAAGCGGAAGAGCAAGTCGGCCGGAGGTGATGGG
TCCTCGCGAGGGACGCCCAAGAAGACCAAGGTGGAGCCCTACAGCCTCACCACTCAGCAG
AGCAGCCTTATCAAGGAGGACAAGAGCAACATGAAGCTGTGGACCGAGATCCTGAAGTCG
CTTAAGGACGGGCCGAAATTTCTGAGCAAAGTGGAGGAGACGTTCCAGTGCATTTGCTGC
CAGGAGCTGGTGTTCCGCCCGATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTGC
CTGGACAGGTCCTTCAAGGCCCAGGTGTTCAGCTGCCCGGCCTGTCGCTATGACCTGGGC
CGGAGCTACGCCATGACCGTGAACCAGCCACTGCAGGCCGTCCTCAGCCAGCTCTTCCCC
GGCTATGGCAGCGGGCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 786 |
| Molecular Weight
| 88339.0 |
| Theoretical pI
| 8.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>UHRF1 protein
MWIQVRTMDGKVAHTVDSLSRLTKVEELRKKIQELFHVEPGLQRLFYRGKQMEDGHTLFD
YDVRLNDTIQLLVRQSLVLPVPVPSSSGGSKERDSELSDTDSGCGLAQSESDKSSNSGEA
ANEPEGKADEDECDETELGLYKVGEYVDARDTNMGAWFEAKVIRVTRKAPAHDQPSSSSS
KPEDDIIYHVTYDDYPENGVVQMTSQNVRARARHTIKWEDLQVGQVVMVNYNPDLPKDRG
FWYDAEILRKRETRTARELHANVRIGGDSLNDCRIVFVDEVFKIERPGEGNPMVENPMRR
KSGPSCKHCKDDERKLCRMCACHVCGGKQDPDKQLMCDECDMAFHIYCLRPPLSSVPPEE
EWYCPDCRIDSSEVVQAGEKLKESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSN
HFGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNHGAYSLVLAGGYEDDVDHGNSF
TYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDLKGAEAKDWRSGKPVRVV
RNVKGRKHSKYAPIEGNRYDGIYKVVRYWPEKGKSGFLVWRFLLRRDDVEPGPWTKEGKD
RIKKLGLTMQYPEGYLEALARKEKENSKQAALDKEEEDGEEGFTSPRKGKRKSKSAGGDG
SSRGTPKKTKVEPYSLTTQQSSLIKEDKSNMKLWTEILKSLKDGPKFLSKVEETFQCICC
QELVFRPITTVCQHNVCKDCLDRSFKAQVFSCPACRYDLGRSYAMTVNQPLQAVLSQLFP
GYGSGR
|
| External Links |
|---|
| GenBank ID Protein
| AAI51672.1 |
| UniProtKB/Swiss-Prot ID
| A7E320 |
| UniProtKB/Swiss-Prot Entry Name
| UHRF1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DAAA02019593 |
| GeneCard ID
| UHRF1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
