| Identification |
|---|
| BMDB Protein ID
| BMDBP02403 |
| Secondary Accession Numbers
| None |
| Name
| Cytosolic carboxypeptidase-like protein 5 |
| Synonyms
|
Not Available
|
| Gene Name
| AGBL5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| AGBL5 |
| Gene Sequence
|
>2154 bp
ATGGAGCTGCGCTGTGGGGGATTGCTGTTCAGTTGTGGGTTTGATTCAGGGAACCTAGCC
CATGTGGAGAAGGTAGAATCTGTGTCTAATGATGGGGAAGGAGTAGCGGGTGGGGCATCA
NCCTCCACCAGCAGCATTGCCTCTTCCCCTGACTATGAATTCAATGTGTGGACCCGACCA
GACTGTGCTGAAACGGAATTTGAGAATGGGAACAGGTCATGGTTCTACTTCAGCGTCCGA
GGAGGAACTCCAGGGAAACTCATCAAGATCAATATCATGAACATGAACAAGCAAAGCAAG
CTGTATTCCCAGGGCATGGCTCCCTTTGTGCGTACACTGCCCACTCGGCCACGCTGGGAA
CGAATTCGAGACCGGCCCACCTTTGAGATGACAGAGACGCAGTTTGTGTTATCCTTCATT
CATCGTTTTGTGGAAGGCCGTGGGGCTACCACCTTCTTCGCCTTCTGCTACCCATTCTCC
TACAGTGACTGCCAGGATTTGCTAAGCCAGCTAGACCAGCGCTTTCTGGAGAACAGCCCT
ACCCACAGCAGCCCCCTGGATACCATCTATTACCACCGGGAGACCCTCTGCTATTCTCTG
GATGGACTTCGTGTAGATCTACTGACGATCAGTTCCTGCCATGGGCTTCGAGAAGATCGA
GAGCCCCGTCTAGAGCAGCTATTTCCTGATGCCAGCACCCCCCGACCATTCCGTTTCACA
GGCAAGAGAATATTCTTCTTAAGCAGTAGGGTACATCCCGGGGAGACTCCATCTAGCTTT
GTCTTCAACGGTTTTCTGGACTTCATTCTTCGACCTGATGATCCCCGGGCCCAAACCCTA
CGTCGCCTGTTTGTCTTTAAGCTGATTCCCATGTTGAACCCTGATGGGGTTGTCCGGGGT
CACTACCGCACAGACTCGCGTGGAGTGAATCTGAATCGCCAGTACCTGAAGCCTGATGCA
GTCCTGCACCCAGCCATCTATGGGGCTAAAGCTGTGCTTCTCTACCACCACGTGCATTCC
CGGCTGAACTCCCAGAGTCCCTCTGAGCACCAGCACAGTTCCCATCTCCCTCCTGATGCT
CCCCTCTCTGACCCTGAGAAAGCCGACAGTCTCCAAAACAGAGCTCACCTTGGGCGCTCA
TCCAGCGGGGATAAACCTGAGGCGTGGACACAGACTGAGGTAGCCGAGCAGAAGCCCAAC
AGCGTGTGGATTACGCCACAGGAGTCAGCTGAGGTGGAGCAGCTGGCCCCCGATGCCATC
CCCCCCAGAGAGAGCGGTGTTGCTTACTACGTGGACCTGCACGGACATGCTTCCAAAAGG
GGCTGCTTCATGTATGGAAACAGCTTTAGTGACGAGAACACCCAGGTGGAAAATATGCTG
TATCCAAAGCTCATCTCCTTGAACTCAGCCCACTTTGACTTCCAGGGCTGCAATTTCTCA
GAGAAGAATATGTATGCCCGAGACCGCAGAGATGGCCAGTCTAAAGAGGGAAGCGGCCGG
GTTGCAATCTACAAAGCCTCAGGGATAATCCACAGCTACACACTTGAATGCAACTACAAC
ACTGGACGCTCAGTAAACAGCATCCCTGCCGCCTGCCATGACAACGGGCGTGCCAGCCCC
CCTCCCCCGCCGGCCTTCCCTTCCAGATACACTGTGGAACTGTTTGAGCAGGTGGGACGA
GCTATGGCCATTGCAGCTCTGGACATGGCGGAGTGCAACCCGTGGCCCCGAATCGTGCTG
TCAGAGCATAGCAGCCTAACAAACCTCCGGGCCTGGATGCTGAAACACGTGCGCAGCAGC
CGAGGCCTGAGCACCACTGTGAACATGAGCATCAGCAAGAAGAGAGGCTCTCGAACTCCA
CCCAGAAGTAACAACGGACTGCCTGTTTCCTGCTCTGAAAACACCTTGAGCCGTGCGCGA
AGTTTTAGTACTGGCACAAGTGCTGGTGGTAGCAGCAGCAGCCAACAAAATTCTCCACAG
ATGAAGAACTCCCCCAGCTTTCCTTTTCATGGCAGCCGGCCTGCGGGGCTGCCAGGCCTG
GGATCTAGCACCCAAAAGGTCAGCCACCGGGTGCTGGGCCCCGTCAGAGGTAAGCTAGTC
TGGGAGCCCCTGCAACAGGTGTTCGGTTGTTTGGGGCATTGCTGGGGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 885 |
| Molecular Weight
| 97441.0 |
| Theoretical pI
| 9.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytosolic carboxypeptidase-like protein 5
MELRCGGLLFSCGFDSGNLAHVEKVESVSNDGEGVAGGASASTSSIASSPDYEFNVWTRP
DCAETEFENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWE
RIRDRPTFEMTETQFVLSFIHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFLENSP
THSSPLDTIYYHRETLCYSLDGLRVDLLTISSCHGLREDREPRLEQLFPDASTPRPFRFT
GKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRG
HYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSPSEHQHSSHLPPDA
PLSDPEKADSLQNRAHLGRSSSGDKPEAWTQTEVAEQKPNSVWITPQESAEVEQLAPDAI
PPRESGVAYYVDLHGHASKRGCFMYGNSFSDENTQVENMLYPKLISLNSAHFDFQGCNFS
EKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASP
PPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRSS
RGLSTTVNMSISKKRGSRTPPRSNNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQ
MKNSPSFPFHGSRPAGLPGLGSSTQKVSHRVLGPVREPRSQDRRRRQQPVTHRPTSSSLA
PSPTPASSNLASSHMGSCLLPNSLSISGSSCSFLSSGDKTEAVMVIGKGLLGAGPRIPCI
RTRLQTCPRRLPARRGPGFPRLGPGWPRAHRRLAEG
|
| External Links |
|---|
| GenBank ID Protein
| AAX46665.1 |
| UniProtKB/Swiss-Prot ID
| Q58CX9 |
| UniProtKB/Swiss-Prot Entry Name
| CBPC5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021818 |
| GeneCard ID
| AGBL5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
