| Identification |
|---|
| BMDB Protein ID
| BMDBP02444 |
| Secondary Accession Numbers
| None |
| Name
| CXXC-type zinc finger protein 5 |
| Synonyms
|
Not Available
|
| Gene Name
| CXXC5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| CXXC5 |
| Gene Sequence
|
>858 bp
ATGTCGAGCCTCAGCAGTGGCCCCCAGGACACCGGCGGCAGCAGCAGCAGCAGCAGCAAT
GGCAGCAGTGGCAGTGGCCCAAAGGCAGGAGTGGCAGACAAGAGTGCGGCGGTGGCCGCT
GCTGCGCCAGCCTCGGTGGCGGATGACGCCCCACCCCCCGAGCGGCGGAACAAGAGCGGC
ATCATCAGTGAACCCCTCAACAAGAGCCTGCGCCGCTCCCGCCCCCTCTCCCACTACTCT
TCGTTTGGGGGCAGCGGCGGCAGTGGCGGTGGCAGCATGATGGGCGGGGAGTCAGCTGAA
AAGGCGGCCGCAGCCGCCGCCTCCCTGTTGGCCAACGGGCACGACCTGGCGGCGGCCATG
GCTGTGGACAAAAGCAACTCTACCTCAAAGCACAAAAGCAGTGCTGTGGCCAGCCTGCTG
AGCAAGGCGGAGCGCGCCACGGAGCTGGGGGCCGAGGGACAGCTGACGCTGCAGCAGTTT
GCGCAGTCCACGGAGATGCTGAAGCGCGTGGTGCAGGAGCACCTACCGCTGATGAGCGAA
GCGGGCGCCGGCCTGCCCGACATGGAGGCTGTGGCGGGTGCCGAAGCCCTCAACGGCCAG
TCCGACTTCCCCTACCTGGGCGCCTTTCCCATCAACCCGGGCCTCTTCATCATGACCCCC
GCGGGCGTGTTCCTGGCTGAGAGCGCGCTGCACATGGCCGGCCTGGCTGAGTACCCCATG
CAGGGAGAGCTGGCCTCCGCCATCAGCTCAGGCAAGAAGAAGCGGAAACGCTGCGGCATG
TGTGCGCCCTGCCGGCGGCGCATCAACTGTGAGCAGTGCAGCAGTTGTAGGAACCGAAAG
ACTGGCCATCAGATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 317 |
| Molecular Weight
| 32650.0 |
| Theoretical pI
| 9.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>CXXC-type zinc finger protein 5
MSSLSSGPQDTGGSSSSSSNGSSGSGPKAGVADKSAAVAAAAPASVADDAPPPERRNKSG
IISEPLNKSLRRSRPLSHYSSFGGSGGSGGGSMMGGESAEKAAAAAASLLANGHDLAAAM
AVDKSNSTSKHKSSAVASLLSKAERATELGAEGQLTLQQFAQSTEMLKRVVQEHLPLMSE
AGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPM
QGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSA
ALEKVMLPTGAAFRWFQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI09663.1 |
| UniProtKB/Swiss-Prot ID
| Q32LB3 |
| UniProtKB/Swiss-Prot Entry Name
| CXXC5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109662 |
| GeneCard ID
| CXXC5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
