| Identification |
|---|
| BMDB Protein ID
| BMDBP02448 |
| Secondary Accession Numbers
| None |
| Name
| E3 ubiquitin-protein ligase TRIM11 |
| Synonyms
|
Not Available
|
| Gene Name
| TRIM11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| TRIM11 |
| Gene Sequence
|
>1407 bp
ATGGCCGCACCCGACCTGTCGACCAACCTCCAAGAGGAGGCCACCTGCGCCATCTGCCTC
GACTACTTCACGGATCCAGTGATGACCGACTGCGGCCACAACTTCTGCCGCGAGTGCATC
CGGCGCTGCTGGGGCCAGCCCGAGGGCCCGTACGCCTGCCCCGAGTGCCGCGAGCTGTTC
CCTCAGAGGAACCTGCGACCCAACCGCCCGCTCGCCAAGATGGCCGAGATGGCGCGGCGC
CTGCACCCACCGTCGCCTGTTCCGCAGGGAGTGTGCGCAGCGCACCGCGAGCCGCTGGCC
GCCTTCTGCGGCGACGAGCTGCGCCTTCTGTGCGCGGCCTGCGAGCGTTCAGGGGAGCAC
TGGGCGCACCGTGTGCGCCCGCTGCAGGACGCGGCCGAAGACCTTAAGAGCAAGCTGGAG
AAATCCCTGGAGCATCTGCGGAAGCAAATGGAGGATGCGCTGCTGTTCCAGGCCCAAGCG
GAGGAGACCTGCTCCCTGTGGCAGAAGATGGTAGAGACCCAGCGGCAGAATGTACTGACC
GAGTTTGAGAGGCTGCGCCGTCTGCTCGTGGAGGAGGAGCAGCTGCTGCTGCAGAGGCTG
GAAGAGGAGGAGCTGGAGGTGCTGCCCCCCTTGAGGGAGAGTGCGGCCCGCCTTGGACAG
CAGAGCGCCCAGCTGGCCGAGCTGATCACCGAGCTGGAGGGCCGCTGCCAGCTGCCTGCA
CTGGGGCTGCTGCAGGACATCAGGGACACACTCCGCAGAGTCCAGGACGTGAAGCTGCAG
CCTCCCGAGGTGGTGCCTATGGAGATGAGGACCGTGTGCAGGGTCCCTGGGCTGGTGGAG
GCCTTGCGGAGGTTCCGAGGGGACATGACCCTGGATCCTGACACAGCCAACCCTGAGTTG
GTGCTGTCCGAGGACCGGAGGAGCGTGCGGCGTGGGGACCTGCGGCAGGCCCTGCCCGAC
AGCCCGGAGCGGTTCGACCCTGGGCCTTGTGTGCTGGGCCGGGAGCCCCTGACCTCGGGC
CGCCACTACTGGGAGGTGGAGGTGGGGGAGCGGGCCAGCTGGGCCCTGGGTGTCTGCAGA
GAGAACGCCAACCGCAAGGAGAAGGGCGAGCTGTTTGCTGGCAACGGCTTCTGGATCCTG
GTGTTCCTGGGAAGCTACTACAACTCCTCCGAGCGAGCTTTTGCCCCTCTCCGAGACCCA
CCCCGGCGCGTGGGCATCTTTCTGGACTACGAGGCTGGACACCTGTCCTTCTACAGTGCC
AATGATGGGTCGCTCTTGTATACCTTTCCTGAGACGCCCTTCTCGGGGACCCTGCGGGCC
CTCTTCTCTCCTCTGTCTAGCAGCCCGACCCCTATGACCATCTGCAGGCTGAAAGGCGGG
CCCGGGGATGGGCTGGCTCCCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 52947.0 |
| Theoretical pI
| 5.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tripartite motif-containing 11
MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELF
PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCAAHREPLAAFCGDELRLLCAACERSGEH
WAHRVRPLQDAAEDLKSKLEKSLEHLRKQMEDALLFQAQAEETCSLWQKMVETQRQNVLT
EFERLRRLLVEEEQLLLQRLEEEELEVLPPLRESAARLGQQSAQLAELITELEGRCQLPA
LGLLQDIRDTLRRVQDVKLQPPEVVPMEMRTVCRVPGLVEALRRFRGDMTLDPDTANPEL
VLSEDRRSVRRGDLRQALPDSPERFDPGPCVLGREPLTSGRHYWEVEVGERASWALGVCR
ENANRKEKGELFAGNGFWILVFLGSYYNSSERAFAPLRDPPRRVGIFLDYEAGHLSFYSA
NDGSLLYTFPETPFSGTLRALFSPLSSSPTPMTICRLKGGPGDGLAPQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI26549.1 |
| UniProtKB/Swiss-Prot ID
| A0JN74 |
| UniProtKB/Swiss-Prot Entry Name
| TRI11_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126548 |
| GeneCard ID
| TRIM11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
