| Identification |
|---|
| BMDB Protein ID
| BMDBP02454 |
| Secondary Accession Numbers
| None |
| Name
| E3 ubiquitin-protein ligase ARIH1 |
| Synonyms
|
Not Available
|
| Gene Name
| ARIH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| ARIH1 |
| Gene Sequence
|
>1668 bp
ATGGACTCGGACGAGGGCTACAACTACGAGTTCGACGAGGACGAAGAGTGCAGCGAGGAG
GACAGCGGCGCCGAGGAGGAGGAGGACGAGGACGACGATGAGCCGGACGATGATAACCTG
GATCTGGGCGAGGTGGAGCTGGTGGAGCCGGGGCTGGGCGTTGGCGGGGAGCGGGACGGA
CTGCTGTGCGGGGAGACGGGCGGCGGCGGCGGCAGCGCTCTGGGGCCCGGAGGTGGCGGC
GGCGGTGGCGGCGGCGGCGGCGGGCCGGGGCATGAGCAGGAGGAGGATTACCGCTACGAG
GTGCTCACGGCCGAGCAGATTCTGCAACACATGGTGGAATGTATCCGGGAGGTCAACGAG
GTCATCCAGAATCCAGCAACTATCACAAGAATACTCCTTAGCCACTTCAATTGGGATAAA
GAGAAGCTAATGGAAAGGTACTTTGATGGAAACCTGGAGAAGCTCTTTGCTGAGTGTCAT
GTAATTAATCCAAGTAAAAAGTCTCGAACACGCCAGATGAATACAAGGTCATCAGCACAG
GATATGCCTTGTCAGATCTGCTACTTGAACTACCCTAACTCGTATTTCACTGGCCTTGAA
TGTGGACATAAGTTTTGTATGCAGTGCTGGAGTGAATATTTAACTACCAAAATAATGGAA
GAAGGCATGGGACAGACTATTTCGTGTCCTGCTCATGGTTGTGATATCTTAGTGGATGAC
AACACAGTTATGCGCCTGATCACAGATTCAAAAGTTAAATTAAAGTATCAGCATTTAATA
ACAAATAGCTTTGTAGAGTGCAATCGACTGTTAAAGTGGTGTCCTGCCCCAGACTGCCAC
CACGTTGTTAAAGTTCAGTATCCTGATGCTAAACCTGTTCGCTGCAAATGTGGGCGCCAG
TTTTGCTTTAACTGTGGAGAAAATTGGCATGACCCTGTTAAATGTAAGTGGTTGAAGAAG
TGGATTAAAAAGTGTGATGATGACAGTGAAACCTCTAATTGGATTGCAGCCAACACAAAG
GAATGTCCCAAATGCCATGTCACAATTGAGAAGGATGGCGGTTGTAATCACATGGTCTGT
CGTAACCAGAACTGTAAAGCAGAGTTTTGCTGGGTGTGTCTTGGCCCTTGGGAACCACAT
GGATCTGCCTGGTACAACTGTAACCGCTATAATGAGGATGATGCAAAGGCAGCAAGAGAC
GCACAGGAGAGATCTAGGGCAGCCCTGCAGAGGTACCTGTTCTACTGTAATCGCTATATG
AACCACATGCAGAGTCTCCGCTTTGAGCACAAACTATATGCTCAGGTGAAACAGAAAATG
GAAGAGATGCAACAGCACAACATGTCCTGGATTGAGGTGCAGTTCCTGAAGAAAGCAGTT
GATGTCCTCTGCCAGTGTCGTGCCACACTCATGTACACTTATGTCTTCGCTTTCTACCTC
AAAAAGAATAACCAGTCCATTATCTTTGAGAATAACCAAGCAGATCTAGAGAATGCCACA
GAGGTGCTCTCGGGTTACCTCGAACGAGATATTTCCCAAGACTCTCTGCAGGATATAAAG
CAGAAAGTACAAGATAAGTACAGATACTGTGAGAGTCGACGAAGGGTTTTGTTACAGCAT
GTGCATGAAGGCTATGAAAAAGATCTGTGGGAGTACATTGAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 555 |
| Molecular Weight
| 64017.0 |
| Theoretical pI
| 4.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein ariadne-1 homolog
MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDNLDLGEVELVEPGLGVGGERDG
LLCGETGGGGGSALGPGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNE
VIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSSAQ
DMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDD
NTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQ
FCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVC
RNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYM
NHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYL
KKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQH
VHEGYEKDLWEYIED
|
| External Links |
|---|
| GenBank ID Protein
| AAI33646.1 |
| UniProtKB/Swiss-Prot ID
| A2VEA3 |
| UniProtKB/Swiss-Prot Entry Name
| ARI1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC133645 |
| GeneCard ID
| ARIH1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
