| Identification |
|---|
| BMDB Protein ID
| BMDBP02488 |
| Secondary Accession Numbers
| None |
| Name
| Anaphase-promoting complex subunit 11 |
| Synonyms
|
Not Available
|
| Gene Name
| ANAPC11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| ANAPC11 |
| Gene Sequence
|
>255 bp
ATGAGGGTGAAGATCAAATGCTGGAACGGCGTGGCCACTTGGCTCTGGGTAGCCAACGAC
GAGAACTGTGGCATCTGCCGGATGGCCTTCAATGGCTGCTGCCCGGACTGCAAGGTGCCG
GGTGACGACTGCCCGCTGGTGTGGGGCCAGTGCTCACACTGCTTCCACATGCACTGCATC
CTCAAGTGGCTGAACGCGCAGCAGGTGCAGCAGCACTGCCCCATGTGCCGCCAGGAGTGG
AAGTTCAAGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 84 |
| Molecular Weight
| 9846.0 |
| Theoretical pI
| 7.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Anaphase-promoting complex subunit 11
MRVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLNAQQVQQHCPMCRQEWKFKE
|
| External Links |
|---|
| GenBank ID Protein
| AAI02427.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZCF6 |
| UniProtKB/Swiss-Prot Entry Name
| APC11_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102426 |
| GeneCard ID
| ANAPC11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
