Showing Protein Baculoviral IAP repeat-containing protein 5 (BMDBP02499)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02499 |
| Secondary Accession Numbers | None |
| Name | Baculoviral IAP repeat-containing protein 5 |
| Synonyms | Not Available |
| Gene Name | BIRC5 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in caspase inhibitor activity |
| Specific Function | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | BIRC5 |
| Gene Sequence |
>429 bp ATGAGTGCTCCGTCGTTGCCCCCGGCCTGGCAGCTCTACCTCAAGGACCACCGCATCTCC ACATTCAAGAACTGGCCCTTCTTGGAGGGCTGCGCCTGCACCCCAGAGCGGATGGCCGAG GCCGGTTTCATCCACTGCCCCACTGAGAACGAGCCCGATTTGGCCCAGTGTTTCTTGTGC TTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCCATAGAAGAACATAAAAAGCAT TCATCCGGTTGTGCTTTCCTTTCTGTCAAGAAGCAGTTTGAAGAATTAACCCTCAGTGAA TTTTTGAAACTGGACAAAGAAAGAGCCAAGAACAAAATTGCAAAGGAAACCAACAATAAG CAGAAAGAATTTGAAGAAACTGCAAAGAAAGTCCGCTGTGCCATTGAGCAGCTGGTTGCC ATGGATTGA |
| Protein Properties | |
| Number of Residues | 142 |
| Molecular Weight | 16341.0 |
| Theoretical pI | 5.34 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Baculoviral IAP repeat-containing protein 5 MGAQSLPPAWQLYLKDHRVSTFKNWPFLEGCACTPERMAAAGFIHCPTENEPDLAQCFFC FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLSEFLKLDKERTKNKIAKETNNK QKEFEETAKKVRCAIEQLAALE |
| External Links | |
| GenBank ID Protein | AAT37504.1 |
| UniProtKB/Swiss-Prot ID | Q6J1J1 |
| UniProtKB/Swiss-Prot Entry Name | BIRC5_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AY606044 |
| GeneCard ID | BIRC5 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |