| Identification |
|---|
| BMDB Protein ID
| BMDBP02546 |
| Secondary Accession Numbers
| None |
| Name
| Arachidonate 5-lipoxygenase-activating protein |
| Synonyms
|
Not Available
|
| Gene Name
| ALOX5AP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in arachidonic acid binding |
| Specific Function
| Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| ALOX5AP |
| Gene Sequence
|
>486 bp
ATGGACCAAGAAGCCGTGGGCAATATCGTCCTGCTGGCCATTGTTACCCTCATCAGTGTG
GTCCAGAATGGGTTCTTTGCCCACAAGGTGGAGCACGAAAGCAAGACCCACAATGGGCGG
AGCTTCCAGAGGACTGGGACGCTGGCCTTTGAGCGGGTCTACACTGCCAACCAGAACTGT
GTGGATGCCTACCCCACCTTCCTCGTCATGCTCTGGAGCGCCGGGCTTCTCTGCAGCCAA
GTTCCTGCTGCCTTTGCTGGGCTGATGTACCTGTTCGTGAGGCAGAAGTACTTTGTCGGC
TACCTCGGGGAGAGAACTCAGAGCACGCCTGGTTACATATTTGGGAAACGCATTATCCTG
TTCCTATTTGCCATGTCCCTCGCTGGGATACTCAACTATTTCTTCATCGCCCTTTTCGGA
AGTGACTTTGAAAACTACATCAAGACCGTCACTACCACCATCTCCCCTCTCCTTCTCATC
CCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 161 |
| Molecular Weight
| 18028.0 |
| Theoretical pI
| 8.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 9-30
- 53-77
- 81-102
- 116-128
|
| Protein Sequence
|
>Arachidonate 5-lipoxygenase-activating protein
MDQEAVGNIVLLAIVTLISVVQNGFFAHKVEHESKTHNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLVMLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFAMSLAGILNYFFIALFGSDFENYIKTVTTTISPLLLIP
|
| External Links |
|---|
| GenBank ID Protein
| AAI18390.1 |
| UniProtKB/Swiss-Prot ID
| Q148F2 |
| UniProtKB/Swiss-Prot Entry Name
| AL5AP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118389 |
| GeneCard ID
| ALOX5AP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
