| Identification |
|---|
| BMDB Protein ID
| BMDBP02555 |
| Secondary Accession Numbers
| None |
| Name
| Leucine-rich glioma-inactivated protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| LGI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| LGI1 |
| Gene Sequence
|
>1602 bp
ATGGAATCAGAGAGAAGCCAAAGGATGGGAAATGCCTGCATCCCCCTGAAAAGAATTGCT
TATTGCCTATGTCTCTTATCTGCGCTTCTGCTGACTGAGGGGAAGAAACCAGCAAAGCCA
AAATGCCCTGCCGTGTGTACTTGTACCAAAGATAATGCCTTATGTGAGAATGCCAGATCC
ATTCCACGCACCGTTCCTCCTGACGTTATCTCATTGTTATTCACATCGAACTCCTTTGAT
GTGATCAGTGATGATGCTTTCATTGGTCTCCCACATCTAGAGTATTTATTCATAGAAAAC
AACAATATCAAGTCCATTTCAAGACATACTTTCCGAGGACTAAAGTCTTTAATTCACCTG
AGCCTTGCAAACAACAATCTCCAGACTCTCCCAAAAGATATTTTCAAAGGCCTGGATTCT
TTAACAAATGTTGACCTGAGAGGTAATTCATTTAATTGTGACTGTAAACTGAAGTGGCTG
GTGGAATGGCTAAGCCACACCAATGCAACTGTCGAAGACATCTATTGTGAAGGCCCTCCA
GAATACAAGAAGCGCAAAATCAATAGTCTTTCCTCCAAGGATTTTGATTGCATCATTACA
GAGTTTGCAAAGTCTCAAGACCTGCCTTATCAATCACTGTCCATAGACACTTTTTCTTAT
ATGAACGATGAGTATGTCGTCATCGCTCAGCCTTTTACTGGAAAGTGCATTTTCCTTGAA
TGGGACCATGTAGAAAAGACCTTCCGGAATTATGACAACATCACAGGCACGTCCACGGTA
GTGTGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTCATTGTGGCCCAGCTGTTTGGC
GGCTCTCACATCTATAAGAGAGACAGCTTTGCAAATAAATTCATAAAAATCCAGGATATT
GAAATCCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGATTGAAAACAACTGG
TACTTCGTTGTGGCTGACAGTTCAAAAGCTGGTTTCACTACCATTTATAAATGGAACGGA
AATGGATTCTACTCCCATCAATCTTTACATGCATGGTACAGGGATACTGATGTGGAATAT
CTAGAAATAGCCAGAACACCTCAGACTCTCAGAACGCCTCATTTAATACTGTCCAGTAGT
TCCCAGCGTCCTGTCATTTATCAGTGGAACAAAGCAATACAATTATTCACTAACCAAACT
GACATCCCTAACATGGAGGATGTATATGCCGTTAAGCACTTCTCAGTGAAAGGCGATGTG
TACATTTGCTTGACAAGATTCATTGGTGATTCCAAAGTAATGAAATGGGGAGGCTCCTCA
TTTCAGGATATTCAGAGGATGCCATCACGAGGATCCATGGTGTTCCAGCCTCTTCAGATA
AATAACTATCAATATGCAATTCTTGGAAGTGATTATTCCTTTACTCAAGTGTATAACTGG
GATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCAGGCACCAAGATCA
TTCACGCATGTGTCCATTAATAAACGCAATTTTCTTTTTGCTTCCAGTTTTAAGGGAAAC
ACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 533 |
| Molecular Weight
| 61161.0 |
| Theoretical pI
| 8.3 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 53-73
- 80-98
- 118-139
- 146-165
- 171-193
- 205-223
- 229-247
- 281-299
- 342-370
- 382-405
- 411-436
- 457-474
- 480-500
|
| Protein Sequence
|
>Leucine-rich glioma-inactivated protein 1
MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
IPRTVPPDVISLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHL
SLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPP
EYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLE
WDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDI
EILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEY
LEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDV
YICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNW
DAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
|
| External Links |
|---|
| GenBank ID Protein
| AAX08851.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9T6 |
| UniProtKB/Swiss-Prot Entry Name
| LGI1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020834 |
| GeneCard ID
| LGI1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
