| Identification |
|---|
| BMDB Protein ID
| BMDBP02575 |
| Secondary Accession Numbers
| None |
| Name
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SMARCD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chromatin modification |
| Specific Function
| Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| SMARCD1 |
| Gene Sequence
|
>1548 bp
ATGGCGGCCCGGGCGGGTTTCCAGTCTGTGGCTCCGAGCGGCGGCGCCGGAGCCTCAGGA
GGGGCGGGTGCGGCGGCTGCCCTGGGCCCGGGCGGGACACCGGGGCCTCCGGTGCGAATG
GGGCCGGCGCCGGGTCAAGGGCTATACCGCTCCCCGATGCCTGGAGCGGCCTATCCGAGA
CCAGGTATGCTACCAGGCAGCCGAATGACACCTCAGGGACCTTCCATGGGACCCCCTGGC
TATGGGGGGAACCCTTCAGTCCGACCTGGCCTGGCCCAGTCAGGGATGGACCAGTCCCTC
AAGAGACCTGCGCCTCAGCAGATCAAGCAGGTCCAGCAGCAGGCGGTCCAAAATCGGAAC
CACAATGCAAAAAAAAAGAAGATGGCTGACAAAATTCTACCTCAAAGGATTCGTGAACTG
GTACCAGAATCCCAGGACTATATGGATCTCTTGGCTTTTGAAAGGAAACTGGACCAGACT
ATCATGAGGAAACGGCTAGATATCCAGGAGGCCTTGAAACGTCCCATCAAGCAAAAACGG
AAGCTGCGAATTTTCATTTCTAACACTTTCAATCCGGCTAAGTCAGATGCCGAGGATGGG
GAAGGGACGGTGGCTTCCTGGGAACTTCGGGTAGAAGGACGGCTCCTAGAGGATTCTGCC
TTGTCCAAATATGATGCCACCAAACAAAAGAGGAAGTTTTCTTCTTTTTTTAAATCCTTG
GTGATCGAACTGGACAAAGACCTGTATGGACCAGACAACCATCTGGTAGAATGGCACAGG
ACCGCCACTACCCAGGAGACGGACGGCTTCCAGGTGAAACGGCCAGGAGACGTGAATGTG
CGGTGCACTGTCCTGCTGATGCTGGACTACCAGCCTCCTCAGTTTAAATTAGACCCTCGT
CTGGCTCGGCTCCTGGGCATCCACACCCAGACCCGTCCGGTGATCATTCAAGCACTGTGG
CAATATATTAAGACACACAAGCTCCAGGACCCACATGAGCGGGAGTTTGTCATTTGTGAC
AAGTACCTCCAGCAGATCTTTGAGTCTCAGCGTATGAAGTTCTCAGAGATTCCCCAACGG
CTCCATGCCTTGCTTATGCCACCTGAGCCCATTATCATAAATCATGTCATCAGTGTTGAC
CCGAATGATCAGAAAAAGACAGCTTGTTATGACATTGATGAGGAAGTGGATGATACCTTG
AAGACCCAGATGAATTCTTTTCTGCTGTCTACTGCCAGCCAGCAGGAGATTGCTACTCTA
GACAACAAGATCCATGAGACAATAGAGACTATCAATCAGCTGAAGACCCAGCGGGAGTTC
ATGCTGAGCTTTGCCAGAGACCCTCAGGGTTTCATCAATGACTGGCTTCAGTCGCAGTGT
CGGGACCTCAAGGTCATGACTGATGTGGTGGGTAACTCAGAGGAGGAGCGCCGAGCAGAG
TTCTACTTCCAGCCTTGGGCCCAGGAGGCCGTGTGTCGATATTTCTACTCCAAGGTGCAG
CAGAGACGACAAGAATTAGAGCAAGCCCTGGGGATCCGAAATACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 515 |
| Molecular Weight
| 58252.0 |
| Theoretical pI
| 9.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
MAARAGFQSVAPSGGAGASGGAGAAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPR
PGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSLKRPAPQQIKQVQQQAVQNRN
HNAKKKKMADKILPQRIRELVPESQDYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKR
KLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDSALSKYDATKQKRKFSSFFKSL
VIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPR
LARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQR
LHALLMPPEPIIINHVISVDPNDQKKTACYDIDEEVDDTLKTQMNSFLLSTASQQEIATL
DNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKVMTDVVGNSEEERRAE
FYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT
|
| External Links |
|---|
| GenBank ID Protein
| AAI09891.1 |
| UniProtKB/Swiss-Prot ID
| Q2TBN1 |
| UniProtKB/Swiss-Prot Entry Name
| SMRD1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109890 |
| GeneCard ID
| SMARCD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
