Showing Protein Ephrin-A1 (BMDBP02588)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02588 |
| Secondary Accession Numbers | None |
| Name | Ephrin-A1 |
| Synonyms | Not Available |
| Gene Name | EFNA1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | EFNA1 |
| Gene Sequence |
>618 bp ATGGAGTTCTTCTGGGCCTCTCTCTTGGGTCTGTGCTGCAGTCTGGCCGCTGCTAACCGC CACACCGTCTTCTGGAACAGTTCAAACCCCAAGTTTTGGAATGAGGACTACACAGTACAT GTGCGGATAGATGACTACCTGGACATCATCTGTCCTCATTACGAGGATAACTCTGTGCCA GATGCGGCCATGGAGCAGTACACACTGTACCTGGTGGAGCACGAGCAGTACCAGCTGTGC CAACCCCAACCCAAGGACCATGCCCGCTGGTTCTGCAAGAGTCCCAAAGCCAAGCATGGC CCGGAGAAGCTGTCTGAGAAGTTCCACCGCTTCACAGGGTTTACCCTCAGCAAGGATTTC AAAGAGGGACACAGCTACTACTACATCTCCAAGCCCATCCACCACCAGGAAGACCGTTGC TTGAGGCTGAAGGTGATGATCGCTGGCAAAATCACTCACAGCCCTCAGGCTCATCCCAAT GCACAAGAGAAGAGACTTCCAGCAGATGACCCGGAGGTGCAGGTTCTGCATAGCATCGGG CACAGCGCCGCTCCTCGCCTCTTCCCACTAGCCTGGGCTGTGCTGCTCCTGCCATTCCTG CTGCTGCAAATCCCGTGA |
| Protein Properties | |
| Number of Residues | 205 |
| Molecular Weight | 23838.0 |
| Theoretical pI | 7.2 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ephrin-A1 MEFFWASLLGLCCSLAAANRHTVFWNSSNPKFWNEDYTVHVRIDDYLDIICPHYEDNSVP DAAMEQYTLYLVEHEQYQLCQPQPKDHARWFCKSPKAKHGPEKLSEKFHRFTGFTLSKDF KEGHSYYYISKPIHHQEDRCLRLKVMIAGKITHSPQAHPNAQEKRLPADDPEVQVLHSIG HSAAPRLFPLAWAVLLLPFLLLQIP |
| External Links | |
| GenBank ID Protein | AAI02890.1 |
| UniProtKB/Swiss-Prot ID | Q3ZC64 |
| UniProtKB/Swiss-Prot Entry Name | EFNA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC102889 |
| GeneCard ID | EFNA1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |