Showing Protein Interferon alpha/beta receptor 1 (BMDBP02589)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02589 |
| Secondary Accession Numbers | None |
| Name | Interferon alpha/beta receptor 1 |
| Synonyms | Not Available |
| Gene Name | IFNAR1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 1 |
| Locus | Not Available |
| SNPs | IFNAR1 |
| Gene Sequence |
>1683 bp ATGCTCGCTCTCCTGGGCGCGACGACCCTGATGCTGGTCGCTGGGAGATGGGTGCTGCCC GCCGCCTCAGGGGAAGCAAATCTGAAGCCTGAAAATGTCGAGATCCACATCATTGATGAC AATTTTTTCCTGAAGTGGAACAGCAGCAGTGAGTCTGTCAAGAATGTGACTTTTTCAGCA GATTATCAAATACTAGGAACGGATAACTGGAAGAAATTGTCTGGATGTCAACATATTACT AGTACCAAATGCAACTTTTCTTCAGTCGAGCTTGAAAATGTTTTTGAAAAAATTGAATTG CGCATAAGAGCAGAAGAAGGAAACAACACTTCCACATGGTATGAGGTTGAGCCATTTGTA CCATTTCTAGAAGCTCAGATTGGTCCCCCAGATGTGCATTTAGAAGCTGAAGATAAGGCA ATAATACTGAGTATCTCTCCCCCTGGAACAAAAGATAGTATCATGTGGGCTATGGATCGT TCAAGCTTTAGGTATAGCGTCGTTATCTGGAAAAACTCTTCAAGTCTAGAAGAAAGAACG GAAACTGTTTATCCCGAAGATAAAATTTATAAACTGTCACCAGAGATTACTTATTGTTTA AAAGTTAAAGCAGAACTGCGTTTACAAAGTAGAGTTGGTTGCTATAGTCCAGTGTATTGT ATAAATACCACAGAGAGACATAAAGTACCTTCACCAGAAAATATACAAATCAATGCTGAC AACCAGATCTATGTTCTTAAGTGGGATTACCCATATGAAAACGCAACTTTTCAAGCTCAG TGGCTCCGTGCCTTTTTTAAAAAGATTCCTGGGAATCATTCAGACAAATGGAAACAAATA CCGAACTGTGAAAATGTCACAAGTACCCACTGTGTCTTTCCTCGAGAGGTTTCCTCAAGG GGAATTTACTATGTCCGTGTACGAGCATCTAATGGAAATGGTACCTCTTTTTGGTCTGAA GAGAAGGAATTTAATACTGAAATGAAAACTATCATATTTCCTCCAGTCATCAGCGTGAAA TCCGTTACTGATGATTCACTGCATGTCAGTGTTGGTGCTTCAGAAGAGTCTGAAAACATG TCTGTGAATCAGCTCTACCCGCTAATTTATGAAGTAATTTTTTGGGAAAACACTTCAAAT GCTGAGAGAAAAGTTCTAGAGAAAAGAACCAATTTTATCTTTCCTGACTTGAAACCGCTG ACTGTGTATTGTGTCAAAGCCAGAGCACTCATTGAAAATGACAGGCGGAATAAAGGGAGC AGTTTTAGTGATACTGTGTGTGAGAAAACAAAACCAGGAAATACTTCCAAAACCTGGCTT ATAGTTGGAACTTGCACTGCATTGTTTTCTATTCCTGTGGTCATTTATGTTGTGAGCGTC TTCTTGAGATGTGTCAAGTATGTGTTCTTTCCATCAAGTAAACCTCCTTCCTCTGTTGAC GAGTATTTCTCCGATCAGCCACTAAGGAATCTACTCCTTTCCACTTCTGAGGAACAAACG GAAAGATGTTTTATAATTGAAAATGCAAGCATTATTACTGAAATAGAAGAGACTGATGAA ATTGATGAAGTTCACAAAAAGTACAGTTCCCAAACTAGTCAAGATTCAGGAAACTATTCA AACGAAGATGAAAACAGTGGAAGCAAAATAAGCGAAGAGTTTCCGCAACAGGACAGTGTG TGA |
| Protein Properties | |
| Number of Residues | 560 |
| Molecular Weight | 63819.0 |
| Theoretical pI | 4.82 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Interferon-alpha/beta receptor alpha chain MLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSA DYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFV PFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERT ETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINAD NQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSR GIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENM SVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGS SFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVD EYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYS NEDENSGSKISEEFPQQDSV |
| External Links | |
| GenBank ID Protein | CAA48484.1 |
| UniProtKB/Swiss-Prot ID | Q04790 |
| UniProtKB/Swiss-Prot Entry Name | INAR1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | X68443 |
| GeneCard ID | IFNAR1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |