| Identification |
|---|
| BMDB Protein ID
| BMDBP02589 |
| Secondary Accession Numbers
| None |
| Name
| Interferon alpha/beta receptor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| IFNAR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| IFNAR1 |
| Gene Sequence
|
>1683 bp
ATGCTCGCTCTCCTGGGCGCGACGACCCTGATGCTGGTCGCTGGGAGATGGGTGCTGCCC
GCCGCCTCAGGGGAAGCAAATCTGAAGCCTGAAAATGTCGAGATCCACATCATTGATGAC
AATTTTTTCCTGAAGTGGAACAGCAGCAGTGAGTCTGTCAAGAATGTGACTTTTTCAGCA
GATTATCAAATACTAGGAACGGATAACTGGAAGAAATTGTCTGGATGTCAACATATTACT
AGTACCAAATGCAACTTTTCTTCAGTCGAGCTTGAAAATGTTTTTGAAAAAATTGAATTG
CGCATAAGAGCAGAAGAAGGAAACAACACTTCCACATGGTATGAGGTTGAGCCATTTGTA
CCATTTCTAGAAGCTCAGATTGGTCCCCCAGATGTGCATTTAGAAGCTGAAGATAAGGCA
ATAATACTGAGTATCTCTCCCCCTGGAACAAAAGATAGTATCATGTGGGCTATGGATCGT
TCAAGCTTTAGGTATAGCGTCGTTATCTGGAAAAACTCTTCAAGTCTAGAAGAAAGAACG
GAAACTGTTTATCCCGAAGATAAAATTTATAAACTGTCACCAGAGATTACTTATTGTTTA
AAAGTTAAAGCAGAACTGCGTTTACAAAGTAGAGTTGGTTGCTATAGTCCAGTGTATTGT
ATAAATACCACAGAGAGACATAAAGTACCTTCACCAGAAAATATACAAATCAATGCTGAC
AACCAGATCTATGTTCTTAAGTGGGATTACCCATATGAAAACGCAACTTTTCAAGCTCAG
TGGCTCCGTGCCTTTTTTAAAAAGATTCCTGGGAATCATTCAGACAAATGGAAACAAATA
CCGAACTGTGAAAATGTCACAAGTACCCACTGTGTCTTTCCTCGAGAGGTTTCCTCAAGG
GGAATTTACTATGTCCGTGTACGAGCATCTAATGGAAATGGTACCTCTTTTTGGTCTGAA
GAGAAGGAATTTAATACTGAAATGAAAACTATCATATTTCCTCCAGTCATCAGCGTGAAA
TCCGTTACTGATGATTCACTGCATGTCAGTGTTGGTGCTTCAGAAGAGTCTGAAAACATG
TCTGTGAATCAGCTCTACCCGCTAATTTATGAAGTAATTTTTTGGGAAAACACTTCAAAT
GCTGAGAGAAAAGTTCTAGAGAAAAGAACCAATTTTATCTTTCCTGACTTGAAACCGCTG
ACTGTGTATTGTGTCAAAGCCAGAGCACTCATTGAAAATGACAGGCGGAATAAAGGGAGC
AGTTTTAGTGATACTGTGTGTGAGAAAACAAAACCAGGAAATACTTCCAAAACCTGGCTT
ATAGTTGGAACTTGCACTGCATTGTTTTCTATTCCTGTGGTCATTTATGTTGTGAGCGTC
TTCTTGAGATGTGTCAAGTATGTGTTCTTTCCATCAAGTAAACCTCCTTCCTCTGTTGAC
GAGTATTTCTCCGATCAGCCACTAAGGAATCTACTCCTTTCCACTTCTGAGGAACAAACG
GAAAGATGTTTTATAATTGAAAATGCAAGCATTATTACTGAAATAGAAGAGACTGATGAA
ATTGATGAAGTTCACAAAAAGTACAGTTCCCAAACTAGTCAAGATTCAGGAAACTATTCA
AACGAAGATGAAAACAGTGGAAGCAAAATAAGCGAAGAGTTTCCGCAACAGGACAGTGTG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 560 |
| Molecular Weight
| 63819.0 |
| Theoretical pI
| 4.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interferon-alpha/beta receptor alpha chain
MLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSA
DYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFV
PFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERT
ETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINAD
NQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSR
GIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENM
SVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGS
SFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVD
EYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYS
NEDENSGSKISEEFPQQDSV
|
| External Links |
|---|
| GenBank ID Protein
| CAA48484.1 |
| UniProtKB/Swiss-Prot ID
| Q04790 |
| UniProtKB/Swiss-Prot Entry Name
| INAR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X68443 |
| GeneCard ID
| IFNAR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
