| Identification |
|---|
| BMDB Protein ID
| BMDBP02590 |
| Secondary Accession Numbers
| None |
| Name
| B-cell antigen receptor complex-associated protein alpha chain |
| Synonyms
|
Not Available
|
| Gene Name
| CD79A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| CD79A |
| Gene Sequence
|
>672 bp
ATGCCTGAGGGTCCCCAAGCCCTGCAAAGCCCGCCTGCCACCATCTTTCTCCTCCTGATC
TCCGCTGCTGGCCTGGGCCCCGGGTGCCAGGCCCTGTGGGTGGAGTGGGGCCCACCCTCG
GTGACGGTGAGCGTGGGGGAGGAGGTGCGCCTCCAGTGCACGCACAATGGCAGCAACACC
AACGTTACGTGGTGGCACGTCCTCCAAAGCAACTCCTCATGGCCCCCTGTGATGTATCGC
GGGGACGTGGGTGCCGGGGGCGAGCTGATCATCAAACCAGTGAACAAGACTCACAGGGGC
ATGTATAGGTGCCAAGTCAGTGATGGCAAGAAGATTCAGCGCTCCTGCGGGACGTACCTC
CGCGTGCGAGACCCGCTCCCTAGGCCCTTCCTGGACATGGGGGAGGGCACCAAGAACAAC
ATCATCACCGCCGAGGGCATCATCCTCCTCATCTGCGCCGTGGTGCCTGGAACACTGCTG
CTCTTCCGGAAACGATGGCAGAACATGAAATTCGGGGCTGATATCCAGGATGACTACGAA
GACGAAAATCTCTATGAGGGCCTGAACCTTGATGACTGCTCCATGTATGAGGACATCTCC
CGGGGCCTCCAGGGTACCTACCAGGACGTGGGCAGCCTCCACATCGGAGATGCTCAGCTG
GAGAAGCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 24630.0 |
| Theoretical pI
| 5.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>B-cell antigen receptor complex-associated protein alpha chain
MPEGPQALQSPPATIFLLLISAAGLGPGCQALWVEWGPPSVTVSVGEEVRLQCTHNGSNT
NVTWWHVLQSNSSWPPVMYRGDVGAGGELIIKPVNKTHRGMYRCQVSDGKKIQRSCGTYL
RVRDPLPRPFLDMGEGTKNNIITAEGIILLICAVVPGTLLLFRKRWQNMKFGADIQDDYE
DENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLHIGDAQLEKP
|
| External Links |
|---|
| GenBank ID Protein
| BAA03899.1 |
| UniProtKB/Swiss-Prot ID
| P40293 |
| UniProtKB/Swiss-Prot Entry Name
| CD79A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D16412 |
| GeneCard ID
| CD79A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
