Showing Protein Scavenger receptor cysteine-rich type 1 protein M130 (BMDBP02596)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02596 |
| Secondary Accession Numbers | None |
| Name | Scavenger receptor cysteine-rich type 1 protein M130 |
| Synonyms | Not Available |
| Gene Name | CD163 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in scavenger receptor activity |
| Specific Function | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | CD163 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 1129 |
| Molecular Weight | 121806.0 |
| Theoretical pI | 5.93 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Scavenger receptor cysteine-rich type 1 protein M130 MVLHDNSGSAGFKRCSVHFGPFTLAVVSVLYACLITSALGGTDKELRLVAGQTKCSGRVE VKVQEEWGTVCNTGWDLAAVSVVCKQLGCPSVIKATGWTNSSAGTGRIWMDHVSCRGNES ALWDCKHEGWGKHNCTHQQDVGVTCSDGSDLEMRLMNGGNRCSGRIEIKFQGQWGTVCDD NFNLDHASVVCKQLGCGSAVSFSGSANFGEGSGPIWFDDLVCHGNESALWNCRHEGWGKH NCDHAEDAGVICLEGADLSLRLVDGVTKCSGRLEVRFQGEWGTVCDDGWDSDDAAVACQQ LGCPTAITAVGRVNASEGTGHIWLDSVSCQGHESAVWQCRHHEWGKHYCNHNEDAGVTCS DGSDLELRLKGGGSRCAGTVEVEIQKLIGKVCDRSWGLKEADVVCKQLGCGSALRTSYQV YSKIQATNTWLFLNNCNGNETSIWDCKNWQWGGLSCEHYHEAKVTCSAHREPRLVGGDIP CSGRVEVKHGDTWGTICDSDFSLESASVLCRELECGSVVSILGGAHFGEGNGQIWAEEFQ CEGNESHLSLCPVAPRLDGTCSHSKDIGVVCSRYTEVRLVGGNTPCEGRVEVKILGTWGP LCNSHWDMEDAHVLCQQLKCGVAASIPGRAPFGKGSGQPWRHMFHCTGTEQHMGDCPVTA LGASLCPEGQVASVICSGNRSQTLYPCNSSSSDPESSVVLEENGVPCIGSGQLRLVNGGG RCAGRIEVYHEGSWGTICDDSWDLDDAHVVCRQLGCGVAINATGSAHFGEGSGPIWLDEV NCNGKEPRISQCRSHGWGRQNCRHKEDAGVICSEFMSLRLISDSSSETCAGRLEVFYNGA WGSVGKSDMSATTVGVVCRQLGCTDKGSIRPAPSDKVENRYMWVDNVRCPKGPETLWQCP SSPWKRRLASPSEETWITCADKIRLQEGTTNCSGRVEVWHGGSWGTVCDDSWDLNDAQVV CRQLGCGLALEAGKEAAFGQGTGPIWLNEVKCKGNESSLWDCPARSWGHSDCGHKEDASV KCSEIAESKGSVKAAGHSSTVALGILGVILLAFLIATLLWIQRRRQRQRLAVSSRGENSV HEIQYREMNSCLKADDLDLYNSSGLWVLRGSIALGFRLVTAAEAERHST |
| External Links | |
| GenBank ID Protein | ACS87934.1 |
| UniProtKB/Swiss-Prot ID | P85521 |
| UniProtKB/Swiss-Prot Entry Name | C163A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | GQ184570 |
| GeneCard ID | CD163 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |