| Identification |
|---|
| BMDB Protein ID
| BMDBP02624 |
| Secondary Accession Numbers
| None |
| Name
| Potassium voltage-gated channel subfamily A member 4 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1505668). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| KCNA4 |
| Gene Sequence
|
>1983 bp
ATGGAGGTTGCAATGGTGAGTGCTGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT
TACGCGGCTCAGGCCCGGGCGCGGGAGCGCGAGAGGCTGGCTCACTCGAGGGCGGCTGCG
GCCGCTGCGGTGGCCGCGGCCACTGCTGCGGTGGAAGGCGGTGGGGGCTCTGGAGGGTCG
CAACACCACCACCACCCATCGCGCGGGGCCTGCACCTCCCACGACCCCCAGAGCGGCCGG
GGAAGTCGGAGGAGGCGGCGACCGCACCCGGAGAAGAAGAAAGTCCACCACCGGCAGAGC
AGCTTCCCTCACTGCTCCGACCTGATGCCCAGTGGCTCGGAGGAGAAGATCCTGCGGGAT
CTGAGTGAGGAGGACGAAGAGGAGGACGACGAGGAGGACGAGGAAGAGGAGGGAAGGTTT
TATTACAGCGAGGAGGACCATGGGGAGGAGTGTTCCTACACCGACCTGCTGGCGCAGGAC
GATGGGGGCGGCGGTGGCGGCGGCAGCGGCGGCGGCGGCTACAGCTCTGTCCGCTACAGC
GACTGCTGTGAACGCGTGGTGATCAATGTCTCGGGTCTGCGCTTCGAGACCCAGATGAAA
ACCCTGGCCCAGTTTCCCGAGACTTTGCTGGGGGACCCTGAGAAGAGGACTCAGTATTTC
GACCCTCTGCGGAACGAGTATTTTTTCGACAGGAACAGGCCTAGCTTTGATGCCATCTTA
TATTATTACCAGTCAGGGGGCCGCCTGAAGAGGCCAGTCAACGTCCCCTTTGATATCTTC
ACTGAGGAGGTGAAGTTCTACCAGCTGGGGGAGGAGGCCCTGCTCAAGTTTCGGGAGGAT
GAGGGCTTTGTGAGAGAGGAGGAGGACAGGGCCTTGCCGGAGAACGAATTTAAGAAGCAG
ATCTGGCTGCTCTTTGAGTATCCGGAGAGCTCCAGTCCAGCGAGGGGCATAGCCATTGTC
TCCGTCCTGGTTATCCTCATCTCCATCGTCATCTTCTGCTTGGAAACCTTGCCGGAGTTT
CGGGACGACAGGGATCTCATCATGGCCCTGAGCACGGGCGGGCACGGTGGGTTGTTGAAC
GACACGTCGGCTCCCCACCCGGAGAACTCAGGGCACACGATCTTCAACGACCCCTTCTTC
ATCGTGGAGACAGTGTGCATCGTGTGGTTTTCTTTCGAGTTTGTGGTTCGCTGCTTTGCC
TGTCCCAGCCAAGCCCTCTTCTTCAAAAACATCATGAACATCATTGACATCGTCTCCATT
TTGCCTTACTTCATCACGCTGGGCACGGATCTGGCCCAGCAGCAGGGGGGTGGCAACGGG
CAGCAGCAGCAGGCCATGTCCTTTGCCATTCTCAGGATCATCCGTCTGGTCCGAGTATTC
CGGATCTTCAAGCTCTCCAGACACTCCAAAGGCCTGCAGATCCTGGGCCACACGCTCCGA
GCCAGCATGCGCGAACTAGGCCTCCTGATCTTCTTCCTCTTCATCGGGGTCATCCTCTTC
TCCAGCGCTGTGTATTTCGCGGAGGCAGATGAGCCGACCACCCACTTCCAAAGCATCCCC
GATGCATTTTGGTGGGCTGTGGTGACCATGACAACCGTGGGCTATGGGGACATGAAGCCC
ATCACGGTGGGGGGCAAGATTGTAGGGTCTCTGTGTGCCATTGCAGGTGTCTTAACCATC
GCTCTGCCCGTGCCAGTGATTGTCTCTAACTTTAACTATTTCTACCACAGAGAGACTGAA
AATGAGGAACAGACACAGCTCACACAGAATGCAGTCAGTTGCCCATACCTCCCTTCTAAT
TTGCTGAAGAAATTTCGGAGCTCTACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTA
GAGATGGAAGAAGGAGTTAAGGAATCTCTCTGTGCAAAGGAGAAGTGTCAGGGAAAGGGG
GATGACAGTGAGACAGATAAAAACAACGTTTCTAATGCGAAGGCTGTGGAGACCGACGTG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 660 |
| Molecular Weight
| 73513.0 |
| Theoretical pI
| 4.9 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 313-334
- 379-400
- 412-432
- 448-468
- 484-505
- 547-575
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily A member 4
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGGGGSGGS
QHHHHPSRGACTSHDPQSGRGSRRRRRPHPEKKKVHHRQSSFPHCSDLMPSGSEEKILRD
LSEEDEEEDDEEDEEEEGRFYYSEEDHGEECSYTDLLAQDDGGGGGGGSGGGGYSSVRYS
DCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAIL
YYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQ
IWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSTGGHGGLLN
DTSAPHPENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSI
LPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLR
ASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKP
ITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSN
LLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEKCQGKGDDSETDKNNVSNAKAVETDV
|
| External Links |
|---|
| GenBank ID Protein
| CAA40349.1 |
| UniProtKB/Swiss-Prot ID
| Q05037 |
| UniProtKB/Swiss-Prot Entry Name
| KCNA4_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X57033 |
| GeneCard ID
| KCNA4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
