| Identification |
|---|
| BMDB Protein ID
| BMDBP02625 |
| Secondary Accession Numbers
| None |
| Name
| Potassium voltage-gated channel subfamily H member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| KCNH1 |
| Gene Sequence
|
>2883 bp
ATGACCATGGCTGGGGGCAGGAAGGGACTGGTGGCCCCGCAAAACACGTTTCTGGAGAAT
ATTGTCCGGCGGTCCAATGATACTAACTTTGTTTTGGGGAATGCCCAGATAGTGGACTGG
CCTATCGTGTACAGCAATGATGGATTTTGCAAGCTGTCTGGCTATCACAGGGCGGAAGTG
ATGCAAAAAAGCAGTACATGCAGTTTTATGTATGGGGAGCTGACCGATAAAGATACCATT
GAAAAAGTGCGGCAAACCTTTGAGAACTATGAGATGAATTCCTTTGAAATTCTGATGTAC
AAGAAGAACAGGACACCTGTGTGGTTCTTTGTGAAAATTGCTCCAATTCGAAACGAACAG
GATAAAGTGGTTTTATTTCTTTGCACTTTCAGTGACATAACCGCTTTCAAACAGCCGATT
GAAGATGATTCATGTAAAGGCTGGGGGAAGTTCGCTCGGCTGACCAGAGCACTGACGAGC
AGCCGGGGTGTCCTGCAGCAGCTGGCTCCCAGCGTGCAGAAAGGCGAGAACGTCCACAAG
CACTCCCGTCTGGCCGAGGTTCTGCAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAA
GAGGCACCAAAGACTCCCCCGCACATCATCTTACACTACTGCGTTTTTAAGACCACGTGG
GACTGGATCATCCTGATCCTAACCTTCTACACAGCCATCCTGGTTCCTTACAACGTCTCC
TTTAAAACCAGGCAGAACAACGTGGCCTGGCTGGTTGTGGACAGCATCGTGGATGTCATT
TTTTTGGTGGACATTGTGCTGAATTTTCACACCACTTTTGTTGGACCCGCTGGGGAGGTG
ATTTCTGACCCCAAACTCATTCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTT
CTGTCCTGTTTGCCCTATGACGTCATCAACGCTTTTGAGAACGTGGATGAGGGCATCAGC
AGCCTGTTCAGCTCTCTGAAAGTTGTCCGGCTGCTCCGCCTGGGACGCGTGGCCCGGAAG
CTGGACCACTACATCGAGTATGGAGCTGCCGTGCTGGTCCTGCTGGTGTGTGTGTTCGGG
CTGGCCGCTCACTGGATGGCCTGCATTTGGTACAGCATCGGGGACTATGAGATCTTCGAC
GAGGACACCAAGACCATCCGCAACAACAGCTGGCTCTACCAGCTGGCCATGGACATTGGC
ACCCCTTACCAGTTTAACGGGTCTGGCTCAGGGAAGTGGGAAGGGGGTCCCAGCAAGAAT
TCCGTCTACATCTCCTCGTTGTATTTCACCATGACCAGCCTCACCAGCGTGGGCTTTGGG
AACATCGCCCCGTCCACAGACATTGAGAAGATCTTTGCCGTGGCCATCATGATGATTGGC
TCCCTCCTCTATGCCACCATCTTTGGGAATGTGACGACCATTTTCCAACAGATGTACGCC
AACACCAACAGGTACCATGAGATGCTCAACAGTGTCCGGGACTTCTTGAAGCTCTACCAG
GTGCCCAAGGGGCTGAGCGAGCGAGTCATGGATTACATCGTGTCCACCTGGTCCATGTCC
AGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCCAAGGACATGAGAGCGGACATC
TGCGTGCACCTAAACCGCAAGGTCTTCAAGGAGCACCCAGCCTTTCGGCTGGCCAGCGAC
GGCTGCCTGCGGGCACTGGCCATGGAGTTCCAGACGGTGCACTGCGCCCCTGGGGACCTC
ATCTACCACGCAGGGGAGAGCGTCGACAGCCTGTGCTTCGTGGTCTCCGGCTCCCTGGAG
GTGATCCAGGATGACGAGGTGGTGGCCATTCTAGGGAAAGGAGACGTGTTTGGAGACGTG
TTCTGGAAGGAAGCCACCCTTGCCCAGTCCTGTGCCAATGTGAGGGCCTTGACCTACTGT
GACCTCCATGTGATCAAGCGGGACGCCCTGCAGAAAGTGCTGGAATTCTACACAGCCTTC
TCCCACTCCTTCTCCCGGAACCTCATTCTCACCTACAACTTGAGGAAGCGGATCGTGTTC
CGGAAGATCAGTGACGTGAAACGGGAGGAGGAGGAGCGCATGAAGCGGAAGAATGAGGCC
CCCCTGATCCTGCCGCCCGACCACCCCGTCCGGCGGCTCTTCCAGAGGTTCCGCCAGCAG
AAGGAAGCCAGGCTGGCCGCGGAGAGGGGCGGGCGGGACTTGGACGACCTGGACGTGGAG
AAGGGCAGCGTCCTCACCGAGCACAGCCACCACGGCCTGGCGAAGGCCAGCGTCGTCACC
GTCCGAGAGAGCCCTGCCACGCCCGTGGCCTTCCCGGCGGCCGCTGCCCCGGCGGGGCTG
GATCACGCCCGGCTGCAGGCGCCTGGGGCCGAGGGCCTGGGCCCCAAGGCCGGCGGGGCC
GACTGCGCCAAGCGCAAGGGCTGGGCCCGCTTCAAGGATGCCTGCGGGCAGGCTGAGGAC
TGGAGCAAGGTGTCCAAGGCCGAGTCCATGGAAACGCTCCCCGAGAGGACGAAGGCCGCC
GGCGAGGCCACACTCAAGAAGACGGACTCGTGCGACAGCGGCATCACCAAGAGCGACCTG
CGTCTGGACAACGTGGGCGAGGCCAGAAGCCCCCAGGACCGGAGCCCCATCTTGGCGGAG
GTCAAGCACTCCTTCTACCCCATCCCCGAGCAGACGCTGCAGGCCGCCGTCCTGGAGGTG
AAGCACGAGCTCAAGGAGGACATCAAGGCCTTGAGCACCAAGATGACGAGCATTGAGAAA
CAGCTCTCTGAGATACTCAGGATATTAACCTCCAGAAGATCCTCTCAGTCGCCTCAGGAG
CTATTTGAAATATCGAGGCCCCAGTCCCCAGAGTCAGAGAGAGACATTTTTGGCGCAAGC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 987 |
| Molecular Weight
| 110918.0 |
| Theoretical pI
| 7.53 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 221-241
- 249-269
- 291-309
- 346-368
- 378-399
- 478-498
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 1
MTMAGGRKGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR
LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY
QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA
VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI
VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV
HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN
VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER
MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGSVLTEHSHHGL
AKASVVTVRESPATPVAFPAAAAPAGLDHARLQAPGAEGLGPKAGGADCAKRKGWARFKD
ACGQAEDWSKVSKAESMETLPERTKAAGEATLKKTDSCDSGITKSDLRLDNVGEARSPQD
RSPILAEVKHSFYPIPEQTLQAAVLEVKHELKEDIKALSTKMTSIEKQLSEILRILTSRR
SSQSPQELFEISRPQSPESERDIFGAS
|
| External Links |
|---|
| GenBank ID Protein
| CAA73842.1 |
| UniProtKB/Swiss-Prot ID
| O18965 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y13430 |
| GeneCard ID
| KCNH1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
