| Identification |
|---|
| BMDB Protein ID
| BMDBP02629 |
| Secondary Accession Numbers
| None |
| Name
| Potassium voltage-gated channel subfamily KQT member 3 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNQ3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. |
| Pathways
|
- Ion Channels and Their Functional Role in Vascular Endothelium
- Muscle/Heart Contraction
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| KCNQ3 |
| Gene Sequence
|
>2601 bp
ATGGGGCTCAAGGCGCGCAGGCCGGCGGGGGCGGCTGGCGGCGGCGGCGACGGGGGCGGC
GGAGGCGGCGGGGCCGCTAACCCGGCCGGAGGGGACGCGGCAGCGGCCGGCGACGAGGAG
CGGAAAGTGGGGCTAGCGCCGGGCGACGTGGAGCAAGTCACCTTGGCGCTGGGAGCCGGA
GCTGACAAAGACGGGACCCTGCTGCTGGAGGGCGGCGGCCGCGACGAGGGGCAGCGGAGG
ACCCCACAGGGCATCGGGCTCCTGGCCAAGACGCCCCTGAGCCGCCCAGTCAAGAGGAAC
AACGCCAAGTACAGACGCATCCAAACTTTGATCTACGACGCCCTCGAGAGACCGCGGGGC
TGGGCGCTGCTCTACCACGCGCTCGTGTTCCTGATTGTCCTGGGGTGCTTGATTCTGGCT
GTCCTGACCACCTTCAGGGAGTACGAGACTGTTTCGGGGGACTGGCTCCTGCTGCTGGAA
ACATTTGCTATTTTCATCTTCGGAGCCGAGTTTGCTTTGAGGATCTGGGCTGCCGGCTGT
TGCTGCCGATACAAAGGCTGGCGGGGACGACTGAAGTTTGCCAGGAAGCCCTTGTGCATG
TTGGACATCTTTGTGCTGATCGCGTCCGTGCCTGTGGTTGCCGTGGGAAACCAGGGCAAC
GTCCTGGCCACGTCCCTGCGGAGCCTGCGCTTCCTGCAGATCCTTCGGATGCTGCGAATG
GACCGGAGGGGCGGCACCTGGAAGCTCCTGGGCTCGGCCATCTGCGCCCACAGCAAAGAG
CTCATCACCGCCTGGTACATCGGGTTCCTGACGCTCATCCTGTCTTCATTTCTCGTCTAC
CTGGTTGAGAAAGATGTGCCGGAGGTGGATGCCCAAGGAGAAGAGATGAAAGAGGAATTT
GAGACCTACGCAGATGCCCTGTGGTGGGGCCTGATCACACTGGCCACCATTGGCTACGGA
GACAAGACGCCCAAAACGTGGGAAGGCCGTCTGATCGCAGCCACCTTTTCCTTAATCGGA
GTCTCCTTTTTTGCCCTGCCAGCCGGCATCCTGGGGTCCGGGCTCGCGCTCAAGGTGCAG
GAACAGCACCGCCAGAAGCACTTTGAGAAAAGGAGGAAGCCCGCTGCTGAGCTCATCCAG
GCCGCCTGGAGGTACTATGCTACCAACCCCAACAGGATTGATCTCGTGGCGACGTGGAGG
TTCTATGAATCAGTCGTCTCTTTTCCATTCTTCAGGAAAGAACAGCTGGATCCAGCAGCC
AGCCAAAAGCTGGGTCTCTTGGATCGGGTTCGCCTTTCTAATCCTCGTGGTAGCAATACT
AAAGGAAAGCTATTTACCCCTCTGAATGTAGATGCCATAGAAGAAAGTCCTTCTAAAGAA
CCAAAGCCTGTTGGCTCAAACAATAAAGAGCGTTTCCGCACCGCCTTCCGCATGAAAGCA
TACGCTTTCTGGCAGAGCTCTGAAGATGCCGGGACAGGGGACCCCACAGCGGAAGACAGG
GGCTACGGGAATGACTTCCTCATCGAAGACATGATCCCCACCCTGAAGGCTGCCATCCGA
GCCGTCAGAATTCTACAATTCCGTCTCTATAAAAAAAAGTTCAAGGAGACTTTGAGGCCT
TATGACGTGAAGGACGTGATTGAACAGTATTCTGCAGGGCATCTCGACATGCTTTCCCGA
ATCAAGTACCTTCAGACAAGAATAGATATGATTTTCACCCCTGGACCTCCATCTACTCCA
AAACATAAGAAGTCTCAGAGAGGAGCCGCCTTCACCTACCCATCCCAGCAGTCTCCCAGG
AATGAACCCTATGTAGCCAGACCATCCACATCAGAAACTGAAGACCAAAGCATGATGGGG
AAGTTTGTGAAAGTCGAAAGGCAGGTTCACGACATGGGGAAGAAACTGGATTTCCTGGTG
GACATGCATCTGCAGCATATGGAGCGGCTCCAGGTGCACGTCGCCGGCTTCTCCCCGAGC
AAGGGGGCCTCCTCGCCCGCCGAGGCCGAGCAGAAGGAGGACCGCAGGGATGCGGATTTG
AAAACCATCATCTGTAACTATTCCGAAACGGGAGCCCCCGATGCCCCCTACAGCTTCCAC
CAGGTGCCCGTCGACAAAGTCGGCCCCTATGGGTTTTTTGCCCACGACCCCGTGAACCTG
CCCCTAGGGGGACCCAGTTCTGGAAAGGGTCATGCGACCCCCTATGCGGAAAGGCCCACC
GTCCTGCCTATCTTGACGCTTCTCGACTCCCGAGGGAGCTACCGCTCCCAGGTGGAACTG
CACGGCCCCTGTTCGGACCGAGTCTCCCCCCGGCAAAGGCGCAGCATCACCCGGGACAGC
GACACGCCCCTGTCCCTGATGTCAGTCAACCACGAGGAGCTGGAACGCTCGCCCAGTGGC
TTCAGCATCTCCCAGGACAGAGACGATTATGCGTTTGGCCCGAGCGGGGGATCGAGCTGG
ATGAGGGAGAAACGGTACCTGGCCGAGGGTGAGACGGACACGGACACCGAGCCCTTCACA
CCCAGTGGCTCCCTCCCTCTGTCGTCCACGGGGGATGGCATTTCTGATTCGATATGGACC
CCTTCCGGCAAGCCCACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 866 |
| Molecular Weight
| 95645.0 |
| Theoretical pI
| 9.23 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 122-142
- 153-173
- 197-217
- 226-247
- 262-282
- 331-351
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily KQT member 3
MGLKARRPAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
WALLYHALVFLIVLGCLILAVLTTFREYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLDPAA
SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGSNNKERFRTAFRMKA
YAFWQSSEDAGTGDPTAEDRGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQRGAAFTYPSQQSPR
NEPYVARPSTSETEDQSMMGKFVKVERQVHDMGKKLDFLVDMHLQHMERLQVHVAGFSPS
KGASSPAEAEQKEDRRDADLKTIICNYSETGAPDAPYSFHQVPVDKVGPYGFFAHDPVNL
PLGGPSSGKGHATPYAERPTVLPILTLLDSRGSYRSQVELHGPCSDRVSPRQRRSITRDS
DTPLSLMSVNHEELERSPSGFSISQDRDDYAFGPSGGSSWMREKRYLAEGETDTDTEPFT
PSGSLPLSSTGDGISDSIWTPSGKPT
|
| External Links |
|---|
| GenBank ID Protein
| AAK11221.1 |
| UniProtKB/Swiss-Prot ID
| P58126 |
| UniProtKB/Swiss-Prot Entry Name
| KCNQ3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF325548 |
| GeneCard ID
| KCNQ3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
