| Identification |
|---|
| BMDB Protein ID
| BMDBP02633 |
| Secondary Accession Numbers
| None |
| Name
| Potassium voltage-gated channel subfamily B member 2 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNB2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| KCNB2 |
| Gene Sequence
|
>2736 bp
ATGGCAGAGAAGGTTCCCCCTGGCTTAAACAGGAAGACGTCAAGGTCGACACTTTCTCTT
CCACCGGAACCAGTGGACATCATTAGGAGCAAAACGTGCTCCCGGAGGGTGAAGATCAAC
GTGGGGGGCCTCAACCACGAGGTCCTGTGGAGAACGTTGGACCGGTTGCCCAGGACCCGC
CTGGGGAAGCTCCGGGACTGCAACACGCACGAGAGCCTCCTGGAGGTGTGCGATGACTAC
AACCTGAACGAGAACGAGTATTTCTTCGATCGGCACCCAGGAGCCTTCACTTCCATTTTA
AATTTCTACCGGACAGGGAAACTCCACATGATGGAAGAAATGTGCGCTCTCTCTTTCGGC
CAAGAGCTTGATTACTGGGGGATCGATGAGATCTACTTAGAGTCGTGCTGCCAAGCCAGG
TATCATCAAAAGAAGGAGCAGATGAACGAAGAACTGCGGCGGGAGGCGGAGACCATGCGG
GAACGCGAGGGTGAAGAGTTTGATAACACCTGCTGCCCTGAGAAGAGAAAGAAACTCTGG
GACCTGCTGGAGAAGCCCAACTCGTCCGTGGCTGCCAAGATCTTGGCTATCGTGTCCATC
TTGTTCATCGTCCTCTCCACCATCGCACTGTCTCTCAACACGCTGCCGGAGCTGCAGGAG
ATGGATGAATTCGGACAGCCCAATGACAACCCCCAGTTGGCTCACGTGGAGGCCGTGTGT
ATCGCCTGGTTTACCATGGAGTACCTTTTACGGTTCCTGTCCTCACCCAACAAATGGAAG
TTCTTCAAAGGCCCGCTGAACGTTATCGACTTGCTGGCCATCTTGCCCTATTACGTCACC
ATCTTCCTCACGGAGTCCAACAAGAGTGTGCTGCAGTTCCAGAATGTTCGCCGCGTGGTC
CAGATCTTCCGGATCATGCGGATCCTCCGGATCCTGAAACTCGCCCGGCACTCCACGGGC
CTGCAGTCCCTGGGCTTCACCCTCAGGCGGAGTTACAATGAACTGGGCTTGCTGATCTTG
TTTCTGGCCATGGGGATAATGATATTCTCCAGCCTGGTATTTTTTGCCGAGAAGGACGAG
GATGCCACCAAGTTCACCAGTATCCCGGCTTCCTTTTGGTGGGCCACCATCACCATGACG
ACTGTCGGTTATGGAGATATCTACCCAAAAACGTTATTAGGGAAGATTGTGGGAGGTCTC
TGCTGTATCGCAGGGGTTCTGGTGATCGCCCTTCCCATCCCAATCATTGTGAACAATTTT
TCTGAGTTTTACAAAGAGCAGAAACGCCAGGAGAAAGCCATTAAGAGGAGAGAGGCTCTG
GAGCGTGCCAAGAGGAACGGAAGCATCGTGTCTATGAACTTAAAGGACGCCTTTGCTCGA
AGTATGGAGCTGATAGACGTGGCCGTGGAGAAGACGGGAGAGTCGGCCAACACCAAGGGC
TCCACGGATGACAATCACCTCTCTCCAAGCCGGTGGAAGTGGGCCAGGAAGGCTCTGTCA
GAAACCAGCTCCAACAAGTCTTACGAGAATAAGTACCAGGAGGTCAGCCAGAAAGACTCC
CATGAACAGCTTAACAACACTTCTTCCTCCAGCCCGCAGCATCTGAGCGCCCAGAAGCTG
GAGATGCTGTACAATGAAATCACCAAGACGCAGCCTCACTCTCACCCGAACCCCGATGGC
CAGGAGCAGGCCGAGAGGCCGTCCACCTACGAGGAAGAGATAGAGATGGAGGAGGTGGTC
TGCCCGCAGGAGCAGCTGGCGGTGGCACAGACCGAGGGCGTCGTGGACATGAAGAGCACA
TCCAGTATCGACAGCTTCACCAGCTGCGCCACAGACTTCACGGAGACTGAGAGGTCGCCC
CTGCCGCCGCCCTCTGCGTCCCACCTGCAGATGAAGTTCCCACCCGACCTGGCCGGGTTA
GAAGAGCACCAAAGAGCCAGGGCTCCCCCCTTCTTAGCCCTAATCAGGCAGAAGGGGCCC
ACGGTCAGGGAGGCCACCCCAGAATATGCTCCGATCGACATAACTGTGAACCTCGACGCC
GCTGGCGGGCCCCAAGGTGGGCCCCACGGCCCTCTGCCGACGGACTGTGCCTCCGAGAGC
CCCAAGAGCTCGCTGAAAGGCAGCAACCCGCTCAAGTCCAGATCGCTCAAGGTCAACTTC
AAGGACAGCAGAGGCGGGGCCCCGCCAACCCCGCCCAGCACAGCCAGGCCGCTGCCGGTC
ACCGCGGCGGACTTTCCACTCACCGCACCCCAGCTCATCAGCACCATTCTCTTAGAAGAA
ACCCCCTCCCAGGGAGATAGACCCTTGCTGGGTGCTGAGGTTCATTGTCAAGGACCCTCC
AAAGGGCTGACGCCTCGGTTTCCCAAGCAGAAACTCTTTACTTTCTCCGCCAGAGAGAGG
AGGAGCTTCACGGAAATCGACACGGGGGAAGATGATGACTTCTTAGAGCTCCAGGGGACC
AGGAGGCCGGACAAGCAGGCAGACTCCAGCCCAAACTGCTTGACAGATAAGCCTAGTGAT
GGAAGAGACCCTTTAAGAGAAGAGGCCTGTGTGGGCTCTTCCTCTGCCCAGGACACAAGT
CACAACTGTAGACAAGGCATTTACCATGGTGTAGCAGAAGTGAAAAAGGACAACAGTCAA
GAAGGGTGCAAGATGGAAAACCATTTGTTTGCCCCAGAAATTCATTCCAACCCGGGAGAC
ACAGGTTACTGCCCCACACGTGAAACCAGCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 911 |
| Molecular Weight
| 102276.0 |
| Theoretical pI
| 6.28 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 191-212
- 233-254
- 266-284
- 297-317
- 333-354
- 396-424
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily B member 2
MAEKVPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR
LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG
QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLW
DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQEMDEFGQPNDNPQLAHVEAVC
IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV
QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE
DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF
SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKTGESANTKG
STDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL
EMLYNEITKTQPHSHPNPDGQEQAERPSTYEEEIEMEEVVCPQEQLAVAQTEGVVDMKST
SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPPDLAGLEEHQRARAPPFLALIRQKGP
TVREATPEYAPIDITVNLDAAGGPQGGPHGPLPTDCASESPKSSLKGSNPLKSRSLKVNF
KDSRGGAPPTPPSTARPLPVTAADFPLTAPQLISTILLEETPSQGDRPLLGAEVHCQGPS
KGLTPRFPKQKLFTFSARERRSFTEIDTGEDDDFLELQGTRRPDKQADSSPNCLTDKPSD
GRDPLREEACVGSSSAQDTSHNCRQGIYHGVAEVKKDNSQEGCKMENHLFAPEIHSNPGD
TGYCPTRETSM
|
| External Links |
|---|
| GenBank ID Protein
| AAY26233.1 |
| UniProtKB/Swiss-Prot ID
| Q4ZHA6 |
| UniProtKB/Swiss-Prot Entry Name
| KCNB2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ009866 |
| GeneCard ID
| KCNB2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
