| Identification |
|---|
| BMDB Protein ID
| BMDBP02635 |
| Secondary Accession Numbers
| None |
| Name
| BTB/POZ domain-containing protein KCTD11 |
| Synonyms
|
Not Available
|
| Gene Name
| KCTD11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive (By similarity). |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| KCTD11 |
| Gene Sequence
|
>555 bp
ATGCTGGGGGCCATGTTTAGGGCTGGTACCCCCATGACTCCCAACCTCAATCCCGAGGGA
GGTGGCCACTACTTCATCGATCGAGATGGCAAGGCCTTCCGGCACATCCTCAATTTCCTC
CGGCTGGGCCGCCTAGACCTGCCCCTTGGATATGGGGAGACAGCGCTTCTCAGGGCAGAG
GCGGACTTTTACCAGATCCGACCCCTCCTGGATGCCCTGCGGGAACTGGAGGCCTCTCGG
GGGACCCCAGCTCCCACAGCCGCCCTGCTCCATGCAGATGTAGATAGCAGCCCCCGCCTG
GTGCACTTCTCTGCTCGTCGAGGCCCACACCACTATGAGCTGAGTTCTGTCCAGGTGGAC
ACCTTCCGGGCCAATCTCTTCTGCACCGACCCTGAGTGTCTGGGTGCCCTGCGGGCCCGA
TTTGGTGTGACCAATGAGGACAGGGCAGAGGGAGGCCCACATTTCCGTCTGGAATGGGCT
CCCCGCCCCGCGGAACTCCCCGAAGTGGAGTACCGCAGACTAGGGCTGCAGCCACTGTGG
ACCGGGGCACCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 232 |
| Molecular Weight
| 26015.0 |
| Theoretical pI
| 6.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>BTB/POZ domain-containing protein KCTD11
MLGAMFRAGTPMTPNLNPEGGGHYFIDRDGKAFRHILNFLRLGRLDLPLGYGETALLRAE
ADFYQIRPLLDALRELEASRGTPAPTAALLHADVDSSPRLVHFSARRGPHHYELSSVQVD
TFRANLFCTDPECLGALRARFGVTNEDRAEGGPHFRLEWAPRPAELPEVEYRRLGLQPLW
TGAPGEPRDVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
|
| External Links |
|---|
| GenBank ID Protein
| AAX46487.1 |
| UniProtKB/Swiss-Prot ID
| Q58DF7 |
| UniProtKB/Swiss-Prot Entry Name
| KCD11_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021640 |
| GeneCard ID
| KCTD11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
