Showing Protein Inward rectifier potassium channel 2 (BMDBP02639)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02639 |
| Secondary Accession Numbers | None |
| Name | Inward rectifier potassium channel 2 |
| Synonyms | Not Available |
| Gene Name | KCNJ2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in inward rectifier potassium channel activity |
| Specific Function | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | KCNJ2 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 427 |
| Molecular Weight | 48286.0 |
| Theoretical pI | 5.47 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Inward rectifier potassium channel 2 MGSVRTNRYSIVSSEEDGMKLATLAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKESK ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPVAVFMVVFQSIVGCIIDAFIIGAVM AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP LRRESEI |
| External Links | |
| GenBank ID Protein | AAB71888.1 |
| UniProtKB/Swiss-Prot ID | O19182 |
| UniProtKB/Swiss-Prot Entry Name | KCNJ2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF020792 |
| GeneCard ID | KCNJ2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |