| Identification |
|---|
| BMDB Protein ID
| BMDBP02641 |
| Secondary Accession Numbers
| None |
| Name
| SH3KBP1-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SHKBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated potassium channel activity |
| Specific Function
| Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| SHKBP1 |
| Gene Sequence
|
>2115 bp
ATGGCGGCCGCGGCCCCTGCAGTCGACGGGGTCCCAGGTCGGGGGCCTCCCGGAGAGGTG
ATTCATCTGAATGTGGGAGGCAAGAGATTCAGTACCTCTCGCCAGACTCTCACCTGGATC
CCAGACTCCTTCTTCTCCAGTCTTCTAAGCGGACGCATCTCGACACTGAAAGATGAGACC
GGAGCCATCTTCATCGACAGGGACCCCACCGTCTTCGCTCCCATCCTCAACTTCCTGCGC
ACCAAAGAGTTGGACCCTAGGGGTGTCCACGGTTCCAGTCTCCTCCATGAAGCCCAGTTC
TATGGGCTGACTCCTCTGGTTCGTCGTCTACAGCTTCTTGAAGAGTTGGATCGATCTTCT
TGTGGAAACGTCCTCTTTACTGGTTACCTGCCTCCACCAGTGTTCCCGGTGAAGCGGCGG
AACCGGCACAGCCTGGTGGGGCCCCAGCAAGCAGGGGGTCGCCCAGCCCCTGTCCGACGG
AGCAACACGATGCCCCCCAACCTGGGCAATGCAGGGCTGCTGGGCCGAATGCTGGATGAG
AAATCCCCTCCCTCCCCATCAGGGCTACCCGAGGAGCCGGGGATGGTGCGCCTGGTGTGC
GGACACCACAACTGGATCGCCGTGGCCTATACCCAGTTTCTTGTCTGCTATAGGCTGAAG
GAAGCCTCCGGCTGGCAGCTGGTATTCTCCAGTCCCCGCCTGGACTGGCCCATTGAGCGC
CTGGCACTCACAGCCCGGGTGCTTGGTGGGGCCTTGGGAGAGCATGACAAGATGGTGGCA
GTAGCCACAGGCAGCGAGATCCTGCTGTGGGCTCTGCAGCCAGAAGGCGGTGGCTCTGAG
ATAGGAGTCTTCCACCTGGGGGTGCCTGTGGAAGCCTTGTTCTTCGTTGGGAACCAGCTC
ATCGCCACAAGCCACACAGGGCGTATCGGCGTGTGGAACGCTGTCACCAAGCACTGGCAG
GTCCAGGAGGTGCAACCCATCACCAGTTACGACGCTGCAGGCTCCTTCCTGCTCCTGGGC
TGCAACAACGGCTCCATCTACTATGTGGATGTGCAGAAATTCCCCCTACGCATGAAGGAC
AACGACCTTCTGGTCAGCGAGCTCTACCGGGACCCGGCAGAGGACGGGGTCACAGCCCTG
AGCGTCTACCTCACCCCCAAGACCAGCGACAGTGGAAACTGGATTGAGATCGCCTACGGG
ACCAGCTCAGGGGGTGTGCGGGTCATCGTGCAGCACCCCGAGACAGTGGGCTCGGGGCCT
CAGCTCTTCCAGACCTTCACCGTGCACCGCAGCCCTGTCACCAAGATCATGCTCTCGGAG
AAGCACCTCATCTCGGTTTGTGCCGACAGCAACCACGTGCGGACATGGTCCGTGACTCGC
TTCCGCGGCATGATTTCCACCCAGCCTGGCTCCACTCCTCTGGCTTCGTTCAAGATCCTG
GCATTGGAGTCGGCCGACGGGCATGGTGGCTGCAGTGCTGGCAATGACATTGGCCCCTAC
GGTGAGCGAGATGACCAGCAAGTGTTCATTCAGAAGGTGGTACCAAGTGCCAGCCAGCTG
TTCGTGCGTCTTTCCTCCACTGGCCAGCGGGTGTGCTCCGTGCGCTCCGTGGACGGCTCA
CCCACCACCGCCTTCACGGTGCTGGAGTGTGAGGGCTCCCGGAGGCTTGGCTCCCGGCCC
CGGCGCTACCTGCTCACCGGCCAGGCCAACGGCAGCCTGGCCATGTGGGACCTGACCACC
GCCATGGATGGCCTCGGCCAGGCCCCTGCAGGGGGCCTGACAGAGGAAGAGCTGATGGAA
CAGCTGGAGCAGTGTGACCTAGCCCCGCTGGCTTCCTCCAGGGGCTCTCTCCCCAGCCCT
TCACCTCGGACCTCTCTCACCAGTCTCCACTCAGCCTTCAGCAACACCTCCCTGTCCAGC
CGTCGGGGGAGCCCAAGCCCCCCACAGGCCGAGGCCCGGCGCCGCGGGGGAGGCAGCTTT
GTGGAGCGCTGCCAGGAACTGGTGCGGAGCGGACCGGAGCCCCGGCGGCCACCAACACCA
GCCCCCCGGCCCTCCTCGGGTCTCGGAGCACCCCTCGTACCCCCCAAGACGAAGCTCAAT
GAAACTTCCTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 704 |
| Molecular Weight
| 75885.0 |
| Theoretical pI
| 8.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 575-599
- 614-634
- 646-667
- 688-709
- 737-756
- 768-790
- 796-820
|
| Protein Sequence
|
>SH3KBP1-binding protein 1
MAAAAPAVDGVPGRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDET
GAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLLEELDRSS
CGNVLFTGYLPPPVFPVKRRNRHSLVGPQQAGGRPAPVRRSNTMPPNLGNAGLLGRMLDE
KSPPSPSGLPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIER
LALTARVLGGALGEHDKMVAVATGSEILLWALQPEGGGSEIGVFHLGVPVEALFFVGNQL
IATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKD
NDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGP
QLFQTFTVHRSPVTKIMLSEKHLISVCADSNHVRTWSVTRFRGMISTQPGSTPLASFKIL
ALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGS
PTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEEELME
QLEQCDLAPLASSRGSLPSPSPRTSLTSLHSAFSNTSLSSRRGSPSPPQAEARRRGGGSF
VERCQELVRSGPEPRRPPTPAPRPSSGLGAPLVPPKTKLNETSF
|
| External Links |
|---|
| GenBank ID Protein
| AAI33280.1 |
| UniProtKB/Swiss-Prot ID
| A3KMV1 |
| UniProtKB/Swiss-Prot Entry Name
| SHKB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133279 |
| GeneCard ID
| SHKBP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
