| Identification |
|---|
| BMDB Protein ID
| BMDBP02649 |
| Secondary Accession Numbers
| None |
| Name
| ATP-sensitive inward rectifier potassium channel 12 |
| Synonyms
|
Not Available
|
| Gene Name
| KCNJ12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inward rectifier potassium channel activity |
| Specific Function
| Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| KCNJ12 |
| Gene Sequence
|
>1284 bp
ATGACTGCGTCCGGCCGCACAAACCCCTACAGCATCGTGTCTTCAGAGGAGGACGGGCTG
CACTTGGTCACCATGTCGGGCGCCAACGGCTTCGGCAATGGCAAGGTGCACACGCGGCGC
AGGTGCCGGAATCGCTTCGTCAAGAAGAATGGCCAGTGCAACATCGAGTTCGCCAACATG
GATGAGAAGTCGCAGCGCTACCTGGCGGACATGTTCACCACGTGCGTGGACATCCGCTGG
CGCTACATGCTGCTCATCTTCTCGCTGGCCTTCCTCGCCTCCTGGTTGCTGTTCGGGGTC
ATCTTCTGGGTCATTGCTGTGGCCCATGGGGACCTGGAGCCTGCTGAAGCCCATGGCCGC
ACGCCGTGCGTGCTGCAGGTGCATGGCTTCATGGCGGCCTTCCTCTTCTCCATTGAGACG
CAGACCACCATTGGCTACGGGCTGCGCTGCGTGACCGAGGAGTGCCCGGTGGCGGTGTTC
ATGGTGGTGGCGCAGTCCATCGTGGGCTGCATCATCGACTCCTTCATGATTGGCGCCATC
ATGGCCAAGATGGCGCGGCCCAAGAAGCGTGCACAGACGCTGCTATTCAGCCACAATGCG
GTGGTGGCGCTGCGTGACGGCAAGCTCTGCCTCATGTGGCGCGTGGGCAACCTACGCAAG
AGCCATATTGTGGAGGCCCACGTGCGGGCCCAGCTCATCAAGCCCCGGGTCACGGAGGAG
GGCGAGTACATCCCGCTGGACCAGATCGACATTGATGTAGGCTTTGACAAGGGCCTGGAC
CGCATCTTCCTGGTGTCTCCCATCACCATCCTGCACGAGATCGACGAGGCCAGCCCTCTG
TTTGGCATCAGCCGGCAGGACCTGGAAACGGATGACTTCGAGATCGTTGTCATCCTGGAG
GGCATGGTGGAGGCCACGGCCATGACCACGCAGGCCCGCAGCTCCTACCTGGCCAACGAG
ATCCTGTGGGGCCACCGCTTTGAGCCTGTCCTCTTTGAGGAGAAAAACCAGTACAAGATC
GACTACTCGCATTTCCACAAGACGTACGAGGTGCCATCCACACCCCGCTGCAGTGCCAAG
GACCTAGTGGAGAACAAGTTCTTGCTGCCAAGCACCAACTCCTTCTGCTACGAGAATGAG
CTGGCCTTCCTGAGCCGCGACGAGGAGGACGAGGTGGACGGAGAGCAAGACAGCCTCGGC
CCCCAGGCCAGGCGCGACTTTGACAGGCCGCAGGCCGGCACAGCCCTTGAGCAGCGGCCT
TACAGACGGGAGTCTGAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 427 |
| Molecular Weight
| 48442.0 |
| Theoretical pI
| 5.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ATP-sensitive inward rectifier potassium channel 12
MTASGRTNPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANM
DEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEAHGR
TPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAI
MAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEE
GEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILE
GMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAK
DLVENKFLLPSTNSFCYENELAFLSRDEEDEVDGEQDSLGPQARRDFDRPQAGTALEQRP
YRRESEI
|
| External Links |
|---|
| GenBank ID Protein
| AAY53910.1 |
| UniProtKB/Swiss-Prot ID
| Q4TZY1 |
| UniProtKB/Swiss-Prot Entry Name
| KCJ12_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ023214 |
| GeneCard ID
| KCNJ12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
