| Identification |
|---|
| BMDB Protein ID
| BMDBP02667 |
| Secondary Accession Numbers
| None |
| Name
| BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| KCTD13 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated potassium channel activity |
| Specific Function
| Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| KCTD13 |
| Gene Sequence
|
>990 bp
ATGTCCGCCGAGGCCTCGGGCCCGGCGGCGGCCGAGGCGCCGTCCCTGGAGGTCGCTAAG
CCCTCGGAACTGGAGCCTGGCTCCGCCGCCTACGGTCTCAAGCCACTGACCACGAACAGC
AAGTACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTGCGCACCCTCACC
GGACAGGACACCAGGCTCAAGGCCATGTTCAGCGGCCGCGCGGAGGTGCTCACGGACGCC
GGAGGCTGGGTGCTGATTGACCGGAGCGGCCGCCATTTTGGTACAATCCTCAACTACCTG
CGGGACGGGTCTGTGCCTCTGCCTGAAAGCACCAGAGAACTGGGGGAGCTGCTGGGCGAA
GCCCGCCACTACCTGGTGCAGGGACTGATTGAGGACTGCCAACTGGCACTGCAGCAAAAA
AGGGAGAACGTATCCCCGCTGTGCCTCATCCCCACGGTGACATCTCCCCGGGAGGAGCAG
CAGCTCCTGGCCAGCACCTCCAAGCCCGTGGTGAAGCTCCTGCACAACCGCAGTAACAAC
AAGTACTCCTACACCAGCACTTCAGACGACAACCTACTTAAGAACATCGAGCTGTTTGAC
AAACTGGCCCTGCGCTTCCACGGGCGGCTGCTTTTCCTCAAGGATGTTCTGGGGGACGAG
ATCTGCTGCTGGTCTTTCTACGGGCAGGGCCGCAAAATCGCCGAGGTGTGCTGCACCTCC
ATTGTCTATGCCACGGAGAAGAAGCAGACCAAGGTGGAATTCCCAGAGGCCCGGATCTTT
GAGGAGACCCTGAACATCCTGATCTACGAGACTCCCCGAGGCCCAGACCCAGCCCTCCTG
GAGGCCACAGGAGGTGCAGCTGGAGGTGGTGGAGCCAGCCGAGGGGAGGATGAGGACAAC
CGAGAGCACCGTGTCCGCAGGATCCACGTCCGGCGCCACATCACGCATGATGAGCGTCCT
CACGGCCAACAGATTGTCTTCAAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 329 |
| Molecular Weight
| 36425.0 |
| Theoretical pI
| 7.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>BTB/POZ domain-containing protein KCTD13
MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLT
GQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGE
ARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNN
KYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTS
IVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDN
REHRVRRIHVRRHITHDERPHGQQIVFKD
|
| External Links |
|---|
| GenBank ID Protein
| AAI11243.1 |
| UniProtKB/Swiss-Prot ID
| Q2T9W0 |
| UniProtKB/Swiss-Prot Entry Name
| BACD1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111242 |
| GeneCard ID
| KCTD13 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
