| Identification |
|---|
| BMDB Protein ID
| BMDBP02675 |
| Secondary Accession Numbers
| None |
| Name
| Steroidogenic factor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| NR5A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| NR5A1 |
| Gene Sequence
|
>1386 bp
ATGGACTATTCGTACGACGAGGACCTGGACGAGCTGTGCCCCGTGTGTGGGGACAAGGTG
TCCGGCTACCACTACGGGCTGCTCACATGCGAGAGCTGCAAGGGCTTCTTCAAGCGCACG
GTGCAGAACAACAAGCACTACACGTGCACCGAGAGCCAGAGCTGCAAGATCGACAAGACT
CAGCGCAAGCGCTGTCCCTTCTGCCGCTTCCAGAAGTGCCTGACGGTGGGGATGCGCCTG
GAAGCTGTGCGCGCTGACCGCATGCGAGGCGGCCGGAACAAGTTTGGGCCCATGTACAAG
CGGGACCGGGCCCTGAAGCAGCAGAAGAAGGCACAGATTCGAGCCAATGGCTTCAAGCTG
GAGACAGGCCCCCCAGTGGGGGTGCCCCCGCCGCCCCCTCCCCCACCGGACTACATGCTG
CCCCATGGCCTGCATGCATCTGAGCCCAAGGGCCTGGCCTCAGGTCCACCAGCTGGGCCA
CTGGGCGACTTTGGGGCCCCAGCGTTGCCTATGGCTGTGCCCAGCGCCCACGGGCCACTG
GCTGGCTACCTCTACCCTGCCTTCCCTGGCCGCGCCATCAAGTCTGAGTACCCAGAGCCC
TATGCCAGCCCCCCACAGCCCGGGCCACCCTACGGCTACCCAGAGCCCTTCTCGGGGGGG
CCTGGTGTGCCCGAGCTTATCCTCCAGCTGCTGCAGCTGGAGCCAGATGAGGACCAAGTG
CGGGCACGCATCGTGGGCTGCCTGCAGGAACCGGCCAAAGGCCGCCCCGACCAGCCTGCG
CCCTTCAGCCTCCTGTGCAGGATGGCCGACCAGACCTTCATCTCCATCGTGGACTGGGCA
CGCAGGTGCATGGTCTTCAAGGAGCTGGAGGTGGCCGACCAGATGACACTGCTGCAGAAC
TGCTGGAGCGAGCTGCTGGTTTTTGACCACATCTACCGTCAGATTCAGCATGGCAAGGAG
GGCAGCATCCTGCTGGTCACAGGGCAGGAGGTGGAGCTGACCACGGTGGCCGCCCAGGCG
GGCTCGCTGCTGCACAGCCTGGTGCTTCGGGCGCAGGAGTTGGTGCTGCAGCTGCACGCG
CTGCAGCTGGATCGCCAGGAGTTCGTCTGCCTCAAGTTCCTCATTCTCTTCAGCCTCGAT
GTGAAGTTCCTGAACAACCACAGCCTGGTGAAGGAGGCTCAGGAGAAGGCCAACGCCGCC
CTGCTTGACTACACCCTGTGCCACTACCCGCACTGTGGGGACAAGTTCCAGCAGCTGCTG
CTGTGCCTGGTGGAGGTGCGGGCGCTGAGCATGCAGGCCAAGGAGTACCTGTACCACAAG
CACCTGGGCAACGAGATGCCCCGAAACAACCTGCTCATCGAGATGCTGCAGGCCAAGCAG
ACTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 461 |
| Molecular Weight
| 51613.0 |
| Theoretical pI
| 7.74 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Steroidogenic factor 1
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPVGVPPPPPPPPDYMLPHGLHASEPKGLASGPPAGPLGDFGAPALPMAVPSAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGPPYGYPEPFSGGPGVPELILQLLQLEPDEDQV
RARIVGCLQEPAKGRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQIQHGKEGSILLVTGQEVELTTVAAQAGSLLHSLVLRAQELVLQLHA
LQLDRQEFVCLKFLILFSLDVKFLNNHSLVKEAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
|
| External Links |
|---|
| GenBank ID Protein
| BAA02764.1 |
| UniProtKB/Swiss-Prot ID
| Q04752 |
| UniProtKB/Swiss-Prot Entry Name
| STF1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| D13569 |
| GeneCard ID
| NR5A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
