| Identification |
|---|
| BMDB Protein ID
| BMDBP02679 |
| Secondary Accession Numbers
| None |
| Name
| cGMP-gated cation channel alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| CNGA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| CNGA1 |
| Gene Sequence
|
>2073 bp
ATGAAGAAAGTGATTATCAATACATGGCACTCTTTTGTAAATATTCCCAATGTGGTTGGA
CCAGATGTTGAAAAGGAAATAACAAGGATGGAAAATGGAGCATGCAGCTCCTTTTCTGGT
GATGATGACGACAGTGCCTCTATGTTTGAAGAATCAGAGACTGAGAACCCCCACGCAAGG
GATTCCTTTAGAAGTAATACACACGGAAGCGGACAACCATCACAGAGGGAGCAATACCTG
CCTGGAGCCATTGCACTTTTTAATGTTAACAACAGCAGCAATAAGGAGCAAGAACCAAAG
GAAAAGAAGAAAAAGAAAAAAGAAAAGAAGAGCAAGCCAGATGATAAAAATGAAAATAAA
AAGGACCCAGAAAAGAAAAAGAAGAAAGAAAAGGACAAAGACAAGAAAAAGAAAGAGGAG
AAAGGCAAAGATAAGAAAGAGGAAGAGAAGAAGGAAGTCGTGGTTATTGATCCCTCAGGA
AATACGTATTACAACTGGCTGTTCTGCATCACCTTACCTGTTATGTATAACTGGACCATG
ATTATTGCAAGAGCATGTTTTGATGAACTTCAGTCTGATTACCTAGAATACTGGCTTGCT
TTTGATTACTTATCAGATGTAGTCTATCTTCTTGATATGTTTGTACGAACAAGGACAGGT
TACCTAGAACAAGGACTACTGGTGAAGGAAGAGCGTAAACTCATAGACAAGTATAAATCA
ACCTTTCAATTTAAACTTGATGTTCTATCAGTGATCCCAACTGATCTGCTGTATATTAAG
TTTGGCTGGAATTATCCAGAAATTAGATTAAACAGATTGTTAAGGATCTCTCGAATGTTT
GAGTTCTTCCAGAGAACAGAAACACGGACAAACTACCCAAACATCTTCAGGATCTCTAAC
CTTGTCATGTACATCATCATCATCATCCACTGGAATGCGTGTGTGTACTTCTCTATTTCC
AAAGCTATTGGGTTTGGAAATGACACATGGGTCTATCCTGATGTTAATGATCCTGATTTT
GGCCGTTTGGCTAGAAAATATGTGTACAGTCTTTACTGGTCTACACTGACTTTGACCACT
ATTGGCGAAACACCACCTCCTGTGAGGGATTCTGAGTATTTCTTTGTGGTGGCTGATTTC
CTCATTGGAGTGTTAATTTTTGCCACCATTGTCGGTAACATAGGTTCTATGATTTCCAAC
ATGAATGCGGCCAGGGCAGAATTTCAAGCAAGAATTGATGCAATCAAGCAATACATGCAT
TTTCGAAATGTAAGCAAAGATATGGAGAAGCGAGTCATTAAATGGTTTGACTATCTGTGG
ACCAACAAAAAAACAGTGGATGAGAGAGAAGTCTTGAAGTATCTACCTGATAAACTAAGA
GCAGAGATCGCCATCAATGTTCATTTAGACACATTAAAAAAGGTGCGCATTTTTGCAGAC
TGTGAAGCTGGTCTGTTGGTGGAGTTGGTCTTGAAATTACAACCCCAAGTCTACAGTCCT
GGAGATTACATTTGCAAGAAAGGGGACATTGGCCGAGAGATGTACATCATCAAGGAAGGC
AAACTCGCCGTGGTGGCTGATGACGGGATCACTCAGTTTGTAGTATTGAGTGATGGCAGC
TACTTTGGTGAAATCAGTATCCTTAATATTAAAGGTAGCAAAGCTGGCAATCGAAGAACA
GCCAATATTAAAAGCATTGGCTACTCAGATCTATTCTGTCTCTCAAAAGATGACCTCATG
GAAGCTCTAACTGAGTACCCAGATGCCAAAGGTATGCTAGAAGAGAAAGGGAAGCAAATT
TTGATGAAAGATGGTCTATTGGACATAAACATTGCAAATGCTGGAAGTGATCCTAAAGAT
CTTGAAGAGAAGGTCACCCGAATGGAGAGCTCAGTAGACCTCCTGCAAACAAGGTTTGCT
CGGATCCTGGCTGAGTATGAGTCAATGCAGCAGAAACTGAAGCAGAGGCTAACCAAGGTT
GAGAAATTCCTGAAACCACTTATTGACACAGAATTTTCAGCTATTGAAGGATCTGGAACT
GAAAGTGGGCCCACAGACTCTACACAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 690 |
| Molecular Weight
| 79602.0 |
| Theoretical pI
| 7.08 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 163-183
- 197-215
- 238-257
- 265-286
- 298-324
- 368-399
|
| Protein Sequence
|
>cGMP-gated cation channel alpha-1
MKKVIINTWHSFVNIPNVVGPDVEKEITRMENGACSSFSGDDDDSASMFEESETENPHAR
DSFRSNTHGSGQPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKPDDKNENK
KDPEKKKKKEKDKDKKKKEEKGKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTM
IIARACFDELQSDYLEYWLAFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEERKLIDKYKS
TFQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISN
LVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPDFGRLARKYVYSLYWSTLTLTT
IGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMH
FRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFAD
CEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGS
YFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQI
LMKDGLLDINIANAGSDPKDLEEKVTRMESSVDLLQTRFARILAEYESMQQKLKQRLTKV
EKFLKPLIDTEFSAIEGSGTESGPTDSTQD
|
| External Links |
|---|
| GenBank ID Protein
| CAA35947.1 |
| UniProtKB/Swiss-Prot ID
| Q00194 |
| UniProtKB/Swiss-Prot Entry Name
| CNGA1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X51604 |
| GeneCard ID
| CNGA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
