| Identification |
|---|
| BMDB Protein ID
| BMDBP02687 |
| Secondary Accession Numbers
| None |
| Name
| Eukaryotic translation initiation factor 5A-1 |
| Synonyms
|
Not Available
|
| Gene Name
| EIF5A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| EIF5A |
| Gene Sequence
|
>465 bp
ATGGCAGATGATTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCGATG
CAGTGCTCAGCATTACGTAAGAATGGCTTCGTGGTGCTCAAAGGCCGGCCATGTAAGATT
GTGGAGATGTCAACTTCTAAGACCGGCAAGCACGGCCATGCCAAGGTCCATCTGGTTGGT
ATTGACATCTTCACTGGGAAGAAATACGAAGATATCTGCCCATCAACTCATAATATGGAT
GTCCCCAACATCAAAAGGAACGATTTTCAGCTGATTGGCATCCAGGATGGATACCTATCA
CTCCTCCAAGACAGCGGGGAGGTGCGAGAGGACCTCCGTCTGCCTGAGGGAGACCTTGGC
AAGGAGATTGAGCAGAAATACGACTGTGGAGAAGAGATTCTGATCACGGTGCTGTCCGCC
ATGACAGAGGAGGCGGCTGTTGCAATCAAGGCCATGGCAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 154 |
| Molecular Weight
| 16832.0 |
| Theoretical pI
| 4.86 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Eukaryotic translation initiation factor 5A-1
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLG
KEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
|
| External Links |
|---|
| GenBank ID Protein
| CAE12194.1 |
| UniProtKB/Swiss-Prot ID
| Q6EWQ7 |
| UniProtKB/Swiss-Prot Entry Name
| IF5A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ577609 |
| GeneCard ID
| EIF5A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
