| Identification |
|---|
| BMDB Protein ID
| BMDBP02701 |
| Secondary Accession Numbers
| None |
| Name
| C-X-C chemokine receptor type 2 |
| Synonyms
|
Not Available
|
| Gene Name
| CXCR2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in interleukin-8 receptor activity |
| Specific Function
| Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| CXCR2 |
| Gene Sequence
|
>1083 bp
ATGACAATCATCCTGAAAGATTTATCTAATAGCAGTATTTTGTGGGAGGGGTTTGAGGAT
GAGTTTGGAAATTACAGCGGCACGCCACCCACAGAAGACTATGATTATAGTCCCTGTGAG
ATAAGCACTGAGACACTCAACAAGTATGCTGTGGTCGTCATCGATGCCCTGGTCTTCTTG
CTAAGCCTCCTGGGAAACTCCCTGGTGATGCTGGTCATCTTATACAGCCGGATTGGTCGC
TCTGTCACTGATGTCTACCTGCTGAACCTGGCCATGGCTGACCTGCTCTTCGCCATGACC
TTGCCTATCTGGACCGCCTCCAAGGCAAAGGGTTGGGTCTTCGGCACACCCCTGTGCAAG
GTGGTCTCACTCCTGAAGGAAGTGAACTTCTACAGCGGTATTCTACTGCTGGCCTGCATC
AGCATGGACCGCTACCTGGCCATTGTCCATGCCACACGCACGCTGACCCAGAAGTGGCAC
TGGGTCAAGTTCATATGTTTAGGCATCTGGGCCCTGTCCGTGATCCTGGCCCTGCCCATC
TTCATCTTCCGTGAGGCCTATCAACCACCGTACTCCGACCTAGTCTGCTACGAGGACCTG
GGTGCCAATACAACGAAATGGCGGATGATAATGCGTGTCCTGCCCCAGACCTTTGGCTTC
CTCCTGCCCCTGCTGGTCATGCTGTTCTGCTACGGATTCACCCTGCGCACGCTATTTTCA
GCCCAAATGGGGCACAAGCACCGGGCCATGCGGGTCATCTTTGCTGTCGTGCTCGTCTTC
CTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGATCGCGGACACCCTCATGAGGGCCCAT
GTGATTGCTGAGACCTGTCAGCGCCGCAATGACATTGGCCGGGCCCTGGATGCCACCGAG
ATCCTGGGCTTCCTGCACAGCTGCCTCAACCCCCTCATCTACGTCTTCATTGGCCAGAAG
TTTCGCCACGGACTCCTCAAGATCATGGCCATCCATGGCCTGATCAGCAAGGAGTTCTTG
GCCAAGGATGGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGAACACGTCTACTACCCTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 40625.0 |
| Theoretical pI
| 8.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 49-75
- 85-105
- 121-142
- 164-183
- 209-231
- 252-273
- 295-315
|
| Protein Sequence
|
>High affinity interleukin-8 receptor B
MTIILKDLSNSSILWEGFEDEFGNYSGTPPTEDYDYSPCEISTETLNKYAVVVIDALVFL
LSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWTASKAKGWVFGTPLCK
VVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKWHWVKFICLGIWALSVILALPI
FIFREAYQPPYSDLVCYEDLGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTLFS
AQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHVIAETCQRRNDIGRALDATE
ILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDGRPSFVGSSSGNTSTTL
|
| External Links |
|---|
| GenBank ID Protein
| AAA84996.1 |
| UniProtKB/Swiss-Prot ID
| Q28003 |
| UniProtKB/Swiss-Prot Entry Name
| CXCR2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U19947 |
| GeneCard ID
| CXCR2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
