Showing Protein Desmocollin-1 (BMDBP02711)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02711 |
| Secondary Accession Numbers | None |
| Name | Desmocollin-1 |
| Synonyms | Not Available |
| Gene Name | DSC1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 24 |
| Locus | 24q21-q22 |
| SNPs | DSC1 |
| Gene Sequence |
>2520 bp ATGGCTGTGGCCTCTGCCGCCCCAGGGAGCATCTTCTGGAAGCAGCTCCTATTCTCTCTC CTGGTTTTAATATTATTTTGCGATGCTTGTCAGAAAATTTCTCTTCAAGTTCCTTCTCAT CTTCGGGCTGAAGCACTTGTAGGCAAAGTGAATCTGAAGGAGTGTCTCCAGTCGGCCAGC CTAATCCTGTCAAGTGATCCTGACTTCAGGATTCTAGAAGATGGCTCCATTTACACAACA CATGACCTTGTTTTGTCTTCTGGAAAGAGTTTTTCGATTTTGCTCTCAGACAGTCAGGGA CAGGGGCAGAAGGAGATAGAAATCATACTGGAAGCAGGAGGAAAGAAGGTTCCTAAGAGA CATATGAAAGACGCAGTCCTCAGGCGAACGAAGAGGCGATGGGCGCCTATTCCGTGTTCG CTGATGGAGAACTCACTAGGTCCATTTCCACAGCATGTGCAGCAGGTTCAGTCTGATGCT GCACAAAACTACACCATCTTTTACTCCATAAGCGGACCAGGGGTAGACAAAGAGCCCTTC AATCTGTTCTTCATAGAAAAAGATACAGGGGATATATTTTGTACAAGAAGCATAGACCGT GAGCAATATCAAGAGTTTCCGATCTATGCCTATGCGACCACTGCAGATGGTTATGCACCT GAGTATCCACTTCCCCTAGTATTCAAAGTTGAAGATGACAATGATAATGCCCCATATTTT GAAAACAAACTGACCGTCTTTACTGTGCCTGAGAATTGCCGAACTGGAACTTCAGTGGGA AAAGTGACTGCAATAGACCTCGATGAGCCTGACACTCTACATACTCGTCTGAAGTACAAA ATCTTGCAGCAAATTCCAAACAATCCAAGACATTTCACTGTACATCCAGACACAGGTGTC ATCACCACAACCACACCTTTACTGGATAGAGAAAAATGTGATACGTATAAGTTAATAATG GAAGTTCGAGACATGGGGGGCCAACCTTTTGGTTTATTTAACACAGGAACAATTACTATT TCTCTTGAGGATGAAAATGATAATGCACCATATTTTACAGAAACTTCTTATACTGTAGAA GTAGAAGAAAACAGAATTGATGTTGAAATTTTACGAATGGCGGTGCATGACCATGATTTG CCAAACACGCCGCACTCGAGGGCTGTGTACCAGATCCTACAGGGAAATGAAAACGGAACC TTCAAAATTAGTACAGACCCAAATACAAATGAAGCGGTCTTGTGTGTTGTCAAGCCACTG AACTATGAAGTCAATCGCCAAGTTGTTTTGCAAATTGGTGTACTTAACGAAGCACAATTC GCTAAGGCAGTAAACTCAAAAACTACTACGACTATGTGTACTACAGTTGTCACTGTTAAA GTTAAAGACCATGATGAGGGCCCTGAGTGCCAGCCACCAGTAAAAGTCATTCAGAGTGAA GACTGCCTCCCCGCAGGCACAGAGCTCCTTGGATACAAAGCAGTGGACCCGGAAAGGGGC ACTGGCGAGGGCTTAAGGTATAAGAAGATACAAGATGAAGATAACTGGTTTGAAATTAAT GAATACACTGGTGACTTGAAAACTGTAAAAGTGCTAGATAGAGAATCAACATTTGTAAAA AACAACCAATACAATGTTTCTGTGATTGCGTTCGATGCAGATGGCAGATCTTGCACTGGA ACGTTAGTAGTTTTTTTGGAAGATAAAAATGACCACCCACCGCAGATAAAACAAGAAGAA CTGACAATTTGCCGGCATGATAAGGATTATGTTGTCCTCGAACCTACAGATCAAGATGGA CCTGACAATGGGCCACCTTTTCAATTCATTCTTGATAATTCTGCCAGCAAACTTTGGACA GTAGAGACAAGGGATGGTAAAACTGCCATTCTTCGGGGGCGGCAAGATCTTGATTATGAC TATTACACTGTTCCTATCCAAATAAAAGACAGACATGGTGCTTCTGCAACACACATATTA CCAGTGAGAGTATGTGATTGTACAATTCCATCCGAATGTAGAATGCCTAGTAAACTTTCG AGAGAGGCAGCACTCGCAAATGTATTCCTTGGAAAATGGGCAATTCTTGCCATGGTGTTG GGTTCTGTATTGTTGTTATGTATTTTGTTCACATGTTTCTGTGTTACTGTTAAGAAAACA GTAAAGAAGTGTTTTCCAGAAGATGTAGCCCAGCAAAATTTAATTGTATCAAATACTGAA GGACCTGGAGAAGAAGTGATGGATGCAAATATTAGACTCCCCACACAGACATCCAACGTT TGTGACACAAGCATATCTGTTGGCACACTTGGTGGCCAGGGAGTCAAAACACAGCAAAGT TTTGAGATGGTCAAAGGCGGCTACACTTTGGATGCCAACAAAGGAGGTGGACATCAGACC CTGGAATCTGTTAAGGGAGTGACGGACACTGGCAGATACACGTACAGTGACTGGCACAAC TTCACCCAACCTCGGCTTGGCGAAGAATCCATTAGAGGACACACTCTGGTTAAAAATTAA |
| Protein Properties | |
| Number of Residues | 893 |
| Molecular Weight | 99648.0 |
| Theoretical pI | 4.89 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Desmocollin-1 MAVASAAPGSIFWKQLLFSLLVLILFCDACQKISLQVPSHLRAEALVGKVNLKECLQSAS LILSSDPDFRILEDGSIYTTHDLVLSSGKSFSILLSDSQGQGQKEIEIILEAGGKKVPKR HMKDAVLRRTKRRWAPIPCSLMENSLGPFPQHVQQVQSDAAQNYTIFYSISGPGVDKEPF NLFFIEKDTGDIFCTRSIDREQYQEFPIYAYATTADGYAPEYPLPLVFKVEDDNDNAPYF ENKLTVFTVPENCRTGTSVGKVTAIDLDEPDTLHTRLKYKILQQIPNNPRHFTVHPDTGV ITTTTPLLDREKCDTYKLIMEVRDMGGQPFGLFNTGTITISLEDENDNAPYFTETSYTVE VEENRIDVEILRMAVHDHDLPNTPHSRAVYQILQGNENGTFKISTDPNTNEAVLCVVKPL NYEVNRQVVLQIGVLNEAQFAKAVNSKTTTTMCTTVVTVKVKDHDEGPECQPPVKVIQSE DCLPTGTELLGYKAVDPERGTGEGLRYKKIQDEDNWFEINEYTGDLKTVKVLDRESTFVK NNQYNVSVIAFDADGRSCTGTLVVFLEDKNDHPPQIKQEELTICRHDKDYVVLEPTDQDG PDNGPPFQFILDNSASKLWTVETRDGKTAILRGRQDLDYDYYTVPIQIKDRHGASATHIL PVRVCDCTIPSECRMPSKLSREAALANVFLGKWAILAMVLGSVLLLCILFTCFCVTVKKT VKKCFPEDVAQQNLIVSNTEGPGEEVMDANIRLPTQTSNVCDTSISVGTLGGQGVKTQQS FEMVKGGYTLDANKGGGHQTLESVKGVTDTGRYTYSDWHNFTQPRLGEKVYLCGQDEEHK LCEDYVRSYSYEGKGSVAGSVGCCSDRQEEEGLDFLDHLEPKFRTLAKTCVKK |
| External Links | |
| GenBank ID Protein | CAA40286.1 |
| UniProtKB/Swiss-Prot ID | Q01107 |
| UniProtKB/Swiss-Prot Entry Name | DSC1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | X56966 |
| GeneCard ID | DSC1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |