| Identification |
|---|
| BMDB Protein ID
| BMDBP02712 |
| Secondary Accession Numbers
| None |
| Name
| Gelsolin |
| Synonyms
|
Not Available
|
| Gene Name
| GSN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin binding |
| Specific Function
| Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| GSN |
| Gene Sequence
|
>2196 bp
ATGGTGGTGGAACACCCCGAGTTCCTCAAGGCAGGGAAGGAGCCCGGCCTGCAGATCTGG
CGTGTGGAGAAGTTCGACCTGGTTCCCGTGCCCCCCAACCTTTACGGAGACTTCTTCACA
GGCGATGCCTATGTCATCCTGAAGACGGTGCAGCTGAGGAATGGGAACCTGCAGTATGAC
CTCCACTACTGGCTGGGCAATGAATGCAGCCAGGACGAGAGCGGGGCAGCCGCCATCTTC
ACCGTGCAGCTGGACGACTACCTGAACGGCCGGGCTGTGCAGCACCGCGAGGTCCAGGGC
TTCGAGTCGGCCACCTTCCTCGGCTACTTCAAGTCCGGCCTCAAGTACAAGAAAGGAGGC
GTGGCATCGGGATTCAAGCACGTGGTCCCCAACGAGGTGGTGGTGCAGAGACTCTTCCAG
GTCAAAGGGCGGCGTGTGGTCCGTGCCACCGAGGTGCCTGTGTCCTGGGAGAGCTTCAAC
AACGGCGACTGCTTCATCCTGGACCTGGGCAACGACATCTACCAGTGGTGTGGCTCCAGC
AGCAACCGCTTTGAGAGGCTGAAGGCCACACAGGTGTCCAAGGGCATCCGGGACAACGAG
CGGAGTGGCCGGGCCCGCGTGCACGTTTCCGAGGAGGGCGCCGAGCCTGAGGCCATGCTC
GAGGTGCTGGGCCCCAAGCCAGCTCTGCCCGCAGGGACTGAGGACACAGCCAAGGAGGAC
GCGGCCAACCGCAAGCTGGCCAAGCTGTACAAGGTCTCCAATGGTGCAGGCACCATGTCG
GTCTCCCTCGTGGCTGACGAGAACCCCTTCGCCCAGGGGGCCTTGAGGTCAGAGGACTGC
TTCATCCTGGACCATGGCAAAGACGGAAAGATCTTTGTCTGGAAAGGCAGGCAGGCCAAC
ACCGAGGAGAGGAAGGCCGCCCTCAAAACAGCGTCCGACTTCATCTCCAAGATGGACTAC
CCCAGGCAGACCCAGGTCTCTGTCCTTCCCGAGGGCGGCGAGACCCCGCTGTTCAAACAG
TTCTTCAAGAACTGGCGGGACCCAGACCAGACGGATGGCCCGGGCCTGAGCTATCTCTCC
AGCCACATTGCCAACGTGGAGCGCGTGCCCTTCGACGCGGCCACCCTGCACACCTCCACT
GCCATGGCTGCCCAGCACGGCATGGATGATGACGGCAGAGGGCAGAAGCAGATCTGGAGA
ATTGAAGGTTCCGACAAAGTGCCGGTGGACCCCGCCACGTACGGACAGTTCTACGGTGGT
GACAGCTACATCATTCTGTACAACTACCGCCACGGCGGCCGTCAGGGACAGATCATCTAC
AACTGGCAGGGCGCCCAGTCCACCCAGGATGAGGTCGCTGCCTCGGCCATCCTGACCGCT
CAGCTGGACGAGGAGCTGGGAGGGACTCCCGTGCGGAGCCGTGTGGTCCAAGGCAAGGAG
CCCGCTCACCTCATGAGCCTGTTTGGCGGGAAACCCATGATCATCTACAGGGGCGGCACC
TCCCGCGAGGGTGGGCAGACGGCCCCCGCCAGCACCCGCCTGTTCCAGGTCCGGGCCAGC
AGCTCTGGAGCCACCCGAGCCGTGGAGGTGATGCCCAAGGCTGGCGCGCTGAATTCCAAC
GATGCCTTTGTCCTGAAGACCCCCTCGGCCGCCTACCTCTGGGTGGGTGCGGGAGCCAGC
GAGGCAGAGAAGACTGGGGCCCTGGAGCTGCTCAGGGTGCTTCGGGCCCAACCCGTGCAG
GTGGCAGAAGGCAGCGAGCCAGACAGCTTCTGGGAGGCCCTGGGTGGGAAGGCCGCCTAC
CGCACGTCCCCACGGCTGAAGGACAAGAAGATGGACGCCCACCCTCCTCGCCTCTTTGCC
TGCTCCAACAAGATCGGACGTTTCGTGATCGAGGAGGTCCCTGGCGAGCTCATGCAGGAA
GACTTGGCCACTGATGACGTCATGCTTCTGGACACCTGGGACCAGGTCTTTGTCTGGGTT
GGTAAGGATTCTCAAGAAGAGGAGAAGACAGAAGCCCTGACCTCTGCTAAGCGCTACATC
GAGACGGACCCAGCTAATCGTGACCGGCGGACCCCCATCACTGTGGTGAAGCAGGGCTTC
GAGCCCCCCTCGTTCGTGGGCTGGTTCCTCGGCTGGGATGACAACTATTGGTCTGTGGAC
CCCTTGGACAGGGCCCTCGCTGAGCTGGCTGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 731 |
| Molecular Weight
| 80731.0 |
| Theoretical pI
| 5.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Gelsolin
MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLRNGNLQYD
LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG
VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNDIYQWCGSS
SNRFERLKATQVSKGIRDNERSGRARVHVSEEGAEPEAMLEVLGPKPALPAGTEDTAKED
AANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALRSEDCFILDHGKDGKIFVWKGRQAN
TEERKAALKTASDFISKMDYPRQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGPGLSYLS
SHIANVERVPFDAATLHTSTAMAAQHGMDDDGRGQKQIWRIEGSDKVPVDPATYGQFYGG
DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVRSRVVQGKE
PAHLMSLFGGKPMIIYRGGTSREGGQTAPASTRLFQVRASSSGATRAVEVMPKAGALNSN
DAFVLKTPSAAYLWVGAGASEAEKTGALELLRVLRAQPVQVAEGSEPDSFWEALGGKAAY
RTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWV
GKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDNYWSVD
PLDRALAELAA
|
| External Links |
|---|
| GenBank ID Protein
| AAI04561.1 |
| UniProtKB/Swiss-Prot ID
| Q3SX14 |
| UniProtKB/Swiss-Prot Entry Name
| GELS_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC104560 |
| GeneCard ID
| GSN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
