| Identification |
|---|
| BMDB Protein ID
| BMDBP02718 |
| Secondary Accession Numbers
| None |
| Name
| Fibulin-5 |
| Synonyms
|
Not Available
|
| Gene Name
| FBLN5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| FBLN5 |
| Gene Sequence
|
>1347 bp
ATGCCAGGATTCAAAAGGATACTCACCGTGACCGTTCTGGCTCTCTGTCTTCCAACTCCT
GGGAATGCACAGCAACAGTGTACTAACGGCTTTGACCTGGACCGCTCGTCAGGACAGTGT
TTAGATGTTGATGAATGCCGGACCATCCCTGAGGCCTGCCGAGGAGACATGATGTGTGTC
AACCAAAACGGCGGGTATTTGTGCATCCCCCGAACGAACCCCGTGTACCGAGGGCCCTAC
TCCAACCCCTACTCCAACCCCTACTCAGCTTCTTACCCAGCAGCTGCACCCCCGCTGTCA
GCTCCAAACTACCCCACCATCTCCAGGCCTCTCATATGCCGCTTTGGATACCAGATGGAT
GAAAGCAACCAGTGTGTGGATGTGGATGAGTGTGCAACGGACTCCCACCAGTGTAACCCT
ACCCAGATTTGCATCAACACCGAAGGAGGCTACACCTGTTCCTGCACGGATGGCTACTGG
CTGCTTGAAGGCCAGTGCTTAGACATTGATGAATGTCGTTATGGCTACTGCCAGCAGCTG
TGCGCGAATGTTCCCGGATCTTATTCCTGTACATGCAACCCTGGTTTTACCCTCAACGAG
GATGGAAGGTCTTGCCAAGACGTGAACGAGTGTGCAACTGAGAATCCCTGTGTACAAACC
TGTGTCAACACCTATGGCTCTTTCATCTGCCGCTGTGACCCAGGATATGAACTCGAGGAT
GATGGCGTTCATTGCAGTGATATGGACGAATGCAGCTTCTCTGAGTTCCTCTGCCAACAC
GAGTGTGTGAACCAGCCAGGCACGTACTTCTGCTCCTGCCCAGCCGGCTACATCCTGCTG
GATGACAACCGGAGCTGCCAGGACATCAACGAGTGTGAGCACAGAAACCACACGTGCATC
CTGCAGCAGACCTGCTACAATTTGCAAGGGGGCTTCAAGTGCATTGACCCCATCCGCTGT
GAGGAGCCTTATCTGCGGATCAGTGATAACCGCTGTATGTGTCCCGCGGAGAATCCTGGC
TGCAGAGACCAGCCCTTCACCATCTTGTACCGGGATATGGACGTGGTGTCAGGACGCTCT
GTTCCCGCTGACATCTTCCAAATGCAAGCAACGACCCGCTACCCTGGGGCTTATTACATT
TTCCAGATCAAGTCTGGGAATGATGGCAGAGAATTCTATATGCGGCAAACGGGCCCCATC
AGTGCCACCCTGGTGATGACTCGCCCCATCAAAGGGCCCCGGGACATACAACTGGACTTG
GAAATGATCACGGTCAACACCGTCATCAACTTCAGAGGCAGCTCTGTGATCCGACTGCGG
ATATATGTGTCCCAGTACCCGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 448 |
| Molecular Weight
| 50164.0 |
| Theoretical pI
| 4.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 313-334
- 379-400
- 412-432
- 448-468
- 484-505
- 547-575
|
| Protein Sequence
|
>Fibulin-5
MPGFKRILTVTVLALCLPTPGNAQQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCV
NQNGGYLCIPRTNPVYRGPYSNPYSNPYSASYPAAAPPLSAPNYPTISRPLICRFGYQMD
ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL
CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELED
DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDDNRSCQDINECEHRNHTCI
LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRS
VPADIFQMQATTRYPGAYYIFQIKSGNDGREFYMRQTGPISATLVMTRPIKGPRDIQLDL
EMITVNTVINFRGSSVIRLRIYVSQYPF
|
| External Links |
|---|
| GenBank ID Protein
| AAX08724.1 |
| UniProtKB/Swiss-Prot ID
| Q5EA62 |
| UniProtKB/Swiss-Prot Entry Name
| FBLN5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020707 |
| GeneCard ID
| FBLN5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
