| Identification |
|---|
| BMDB Protein ID
| BMDBP02723 |
| Secondary Accession Numbers
| None |
| Name
| Calcium and integrin-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CIB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| CIB1 |
| Gene Sequence
|
>576 bp
ATGGGGGGTTCGGGCAGTCGCCTATCCAAGGAGCTGCTGGCCGAGTACCAGGACTTGACG
TTCCTGACCAAACAGGAGATCCTTCTAGCCCACAGACGGTTCTGTGAGCTGCTTCCCCAG
GAGCACCGGAGTGTGGAGGAGTCACTGCAGGCTCGAGTGTCCTTGGAGCAGATCCTCAGC
CTTCCAGAGCTCAAGGCCAACCCCTTCAAGGAGCGAATCTGCAAGGTCTTCTCCACTTCC
CCGAGCAGAGACAGCCTGAGCTTTGAGGACTTCTTGGACCTCCTCAGTGTGTTTAGTGAC
ACAGCCACCCCAGACATCAAGTCCCACTATGCCTTCCGCATCTTCGACTTTGATGATGAT
GGAACCTTGAACAGAGAAGACCTGAGCCAGCTCGTGAACTGCCTCACGGGAGAGAGCGAA
GACACACGGCTCAGTGCTTCAGAGATGAAGCAGCTCATCGACAACATCCTAGAGGAGTCT
GACATAGATAGGGATGGGACCATCAACCTCTCCGAGTTCCAGCATGTCATCTCCCGCTCA
CCAGATTTTGCCAGTTCCTTTAAGATTGTCCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 191 |
| Molecular Weight
| 21728.0 |
| Theoretical pI
| 4.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 122-142
- 153-173
- 197-217
- 226-247
- 262-282
- 331-351
|
| Protein Sequence
|
>Calcium and integrin-binding protein 1
MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEHRSVEESLQARVSLEQILS
LPELKANPFKERICKVFSTSPSRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDD
GTLNREDLSQLVNCLTGESEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRS
PDFASSFKIVL
|
| External Links |
|---|
| GenBank ID Protein
| AAI18411.1 |
| UniProtKB/Swiss-Prot ID
| Q17QE5 |
| UniProtKB/Swiss-Prot Entry Name
| CIB1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC118410 |
| GeneCard ID
| CIB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
