Showing Protein Alpha-actinin-4 (BMDBP02725)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02725 |
| Secondary Accession Numbers | None |
| Name | Alpha-actinin-4 |
| Synonyms | Not Available |
| Gene Name | ACTN4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | ACTN4 |
| Gene Sequence |
>2736 bp ATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGGGAGCAAT GGCGCTGGCGGCGGGGGTACCATGGGAGACTACATGGCCCAGGAGGACGACTGGGACCGG GACCTGCTGTTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACAGCCTGGTGC AACTCCCACCTGCGGAAGGCCGGCACGCAGATCGAGAACATTGATGAGGACTTCCGAGAC GGGCTCAAGCTCATGCTCCTCCTGGAGGTCATTTCAGGGGAGCGGTTACCTAAGCCAGAG CGGGGCAAGATGAGAGTGCACAAAATCAACAACGTGAACAAGGCACTGGACTTCATCGCC AGCAAAGGGGTCAAGCTGGTCTCCATCGGGGCGGAAGAGATTGTGGACGGCAACGCGAAG ATGACCCTGGGAATGATCTGGACCATCATCCTCAGGTTCGCCATCCAGGACATCTCTGTG GAAGAGACCTCTGCCAAGGAGGGGCTCCTCCTCTGGTGCCAGAGAAAGACGGCCCCGTAC AAGAACGTCAACGTGCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCC CTGATCCACCGGCACAGACCAGAGCTGATCGAGTACGACAAGCTGAGAAAGGACGACCCC GTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATG CTAGATGCAGAGGACATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTAT GTGTCCAGCTTCTACCATGCCTTTTCGGGAGCGCAGAAGGCTGAGACCGCTGCCAACCGG ATCTGCAAGGTGCTGGCCGTCAACCAGGAGAACGAGCACCTGATGGAAGATTATGAGAGG CTGGCCAGCGACCTCCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGCGTG CCGCAGAAAACCATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCGACTACCGGCGG GTCCACAAGCCGCCGAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTG CAGACCAAGCTGCGCCTCAGCAACCGGCCTGCCTTCATGCCCTCCGAGGGCAAGATGGTG TCGGACATCAACAACGGCTGGCAGCACCTGGAGCAGGCCGAGAAGGGCTACGAGGAGTGG CTGCTGAACGAGATCCGCCGGCTGGAGCGGCTCGACCACCTGGCAGAGAAGTTCCGGCAG AAGGCCTCCATCCACGAGGCCTGGACCGATGGGAAGGAGGCCATGCTGAAGCACCGGGAC TATGAGACGGCCACCCTGTCGGACATCAAGGCCCTCATCCGCAAGCACGAAGCCTTCGAG AGCGACCTGGCCGCCCACCAGGACCGCGTGGAGCAGATTGCCGCCATCGCCCAGGAGCTC AACGAGCTGGATTACTACGACTCCCACAACGTCAACACGCGCTGCCAGAAGATCTGTGAC CAGTGGGACGCCCTTGGCTCTCTGACCCACAGTCGCAGGGAAGCCCTGGAGAAAACGGAG AAGCAGCTAGAGACCATCGACCAGCTGCACCTGGAGTACGCCAAGCGGGCAGCCCCCTTC AACAACTGGATGGAGAGCGCCATGGAGGACCTCCAGGACATGTTCATCGTCCACACCATC GAGGAAATCGAGGGTCTGATCTCAGCCCACGACCAGTTCAAGTCGACGCTGCCAGATGCC GACAGGGAGCGGGAGGCCATCCTGGCCATCCACAAGGAAGCCCAGCGGATCGCCGAGAGC AACCACATCAAGCTCTCGGGCAGCAACCCCTACACCACCGTCACTCCCCAGATCATCAAT TCCAAGTGGGAGAAGGTGCAGCAGCTGGTGCCCAAGCGGGACCACGCCCTCCTGGAGGAG CAGAGCAAACAACAGTCCAACGAGCACCTCCGCCGCCAGTTCGCCAGCCAGGCCAATATT GTGGGGCCCTGGATCCAGACGAAGATGGAGGAGATCGGGCGCATCTCTATCGAGATGAAT GGGACGCTGGAGGACCAGCTGAGCCACCTGAAGCAGTATGAGCGCAGCATTGTGGACTAC AAGCCCAACCTGGACCTGCTCGAGCAGCAGCACCAGCTCATCCAGGAGGCCCTCATCTTC GACAACAAGCACACCAACTATACCATGGAGCACATCCGGGTGGGCTGGGAGCAGCTGCTC ACCACCATCGCCCGCACCATCAACGAGGTCGAGAACCAGATCCTCACCCGCGACGCCAAG GGCATCAGCCAGGAGCAGATGCAGGAGTTCCGGGCGTCCTTCAACCACTTCGACAAGGAC CACGGCGGGGCGCTGGGGCCGGAGGAGTTCAAGGCCTGCCTCATCAGCCTGGGCTACGAC GTGGAGAACGACCGGCAGGGCGATGCCGAGTTCAACCGCATCATGAGCGTAGTGGACCCC AACCACAGCGGCCTCGTGACCTTCCAAGCCTTCATCGACTTCATGTCGAGGGAGACCACC GACACAGACACGGCCGACCAGGTCATCGCCTCCTTCAAGGTCCTGGCTGGGGACAAGAAC TTCATCACAGCCGAGGAGCTGCGGAGAGAGCTGCCGCCCGACCAGGCCGAGTACTGCATC GCCCGCATGGCGCCCTACCAGGGCCCTGACGCCGTGCCTGGCGCCCTCGACTATAAGTCC TTCTCCACAGCCCTGTACGGAGAGAGCGACCTGTGA |
| Protein Properties | |
| Number of Residues | 911 |
| Molecular Weight | 104928.0 |
| Theoretical pI | 5.12 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Alpha-actinin-4 MVDYHAANQSYQYGPSSGSNGAGGGGTMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYER LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPF NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANI VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD HGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETT DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS FSTALYGESDL |
| External Links | |
| GenBank ID Protein | AAI40513.1 |
| UniProtKB/Swiss-Prot ID | A5D7D1 |
| UniProtKB/Swiss-Prot Entry Name | ACTN4_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC140512 |
| GeneCard ID | ACTN4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |