Showing Protein Endothelial differentiation-related factor 1 (BMDBP02732)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02732 |
| Secondary Accession Numbers | None |
| Name | Endothelial differentiation-related factor 1 |
| Synonyms | Not Available |
| Gene Name | EDF1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Transcription |
| Specific Function | Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 11 |
| Locus | Not Available |
| SNPs | EDF1 |
| Gene Sequence |
>447 bp ATGGCTGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAAAAGGGCCCCACGGCCGCC CAGGCCAAGTCCAAGCAGGCCATCTTAGCGGCTCAGAGACGAGGAGAAGATGTGGAGACT TCTAAGAAATGGGCCGCCGGCCAGAACAAGCAGCATTCGATCACCAAGAACACGGCCAAG CTGGACCGGGAGACCGAGGAGCTGCACCACGATCGGGTCACCCTGGAGGTCGGCAAGGTC ATCCAGCAGGGCCGGCAGAGCAAGGGGCTGACGCAGAAGGACTTGGCCACGAAAATCAAC GAGAAGCCGCAAGTCATTGCGGACTACGAGAGTGGCCGGGCCATTCCCAACAACCAGGTT CTGGGCAAGATCGAGAGAGCCATTGGCCTGAAGCTCCGGGGGAAGGACATTGGGAAGCCG ATCGAGAAGGGGCCAAGGGCAAAATGA |
| Protein Properties | |
| Number of Residues | 148 |
| Molecular Weight | 16369.0 |
| Theoretical pI | 10.72 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Endothelial differentiation-related factor 1 MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAK LDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQV LGKIERAIGLKLRGKDIGKPIEKGPRAK |
| External Links | |
| GenBank ID Protein | AAI02247.1 |
| UniProtKB/Swiss-Prot ID | Q3T0V7 |
| UniProtKB/Swiss-Prot Entry Name | EDF1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC102246 |
| GeneCard ID | EDF1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |