Identification
BMDB Protein ID BMDBP02737
Secondary Accession Numbers None
Name Desmocollin-2
Synonyms Not Available
Gene Name DSC2
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 24
Locus 24q21-q22
SNPs DSC2
Gene Sequence Not Available
Protein Properties
Number of Residues 863
Molecular Weight 95875.0
Theoretical pI 4.84
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 645-665
Protein Sequence
>Desmocollin-2
KFIGRVNLKECFKSATLIHSSDPDFQILEDGSVYTTHAILLSSEKSSFTILLSNTETQEE
KEILVLLEHQTKVLKKRHSQEKVLRRAKRRWAPIPCSVPENSLGPFPLFLQQIQSDTAQN
YTIYYSISGPGVDKEPRNLFYVERDTGNLFCTASIDRETYPLFELVAFATTPDGYTPEYP
LTLVIRIEDENDNAPIFTETSYSFEVFENSKVGTTVGQVCATDQDEPDTLHTRLKYSIIE
QFPALPTLFSMHPTTGVITTSSSKLDRELIDKYQLKIKVQDMDGQYFGLQTTAICIINIE
DVNDNLPTFTRSSYVASVEENRIDVEILRVAVRDKDLINTANWRANYTILKGNEDGNFKI
VTDSQTNEGVLCVVKPLNYEEKQQVTLEIGVVNEAPYTGTSRSTTNMATVTVNVQNQDEG
PECDPRVQTVRIKENVPVGTKTIGYKAYDPETGSSSGIRYKKSSDPEGWVDVDKNSGVIT
ILKRLDREARSGVYNISIIASDKDGRTCNGVLGIVLEDVNDNGPVIPQRTVVICKTVMSS
AEIVAVDPDEPIHGPPFDFSLEGVSDSEVLRMWRLTKVNDTAARLSYLNDLRFGKYTVPV
RVTDRLGQSLVTQLVVILCDCVTPNDCSFRPVSRTGNREVILGKWAILAILLGIALLFCI
LFTLVCGATTGADKKPKVFPDDLAQQNLIVSNTEAPGDDKVYSTNDFTTHAVGGSAHGIG
GTLGSRVKNGGQETIEMVKGGHQTMESCQETGHDHTLERCKEGGQHTLDSCRGGPVATDN
CKYTYSEWYTYTQPRLGEKVQQCDQDNTHMQAQDYVLTYNYEGRGSAAGSVGCCSERQEE
DGLEFLDHLGPKFRTLAETCMKR
GenBank ID Protein AAA30782.1
UniProtKB/Swiss-Prot ID P33545
UniProtKB/Swiss-Prot Entry Name DSC2_BOVIN
PDB IDs Not Available
GenBank Gene ID M81190
GeneCard ID DSC2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available