| Identification |
|---|
| BMDB Protein ID
| BMDBP02743 |
| Secondary Accession Numbers
| None |
| Name
| Endothelin-1 receptor |
| Synonyms
|
Not Available
|
| Gene Name
| EDNRA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in endothelin receptor activity |
| Specific Function
| Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| EDNRA |
| Gene Sequence
|
>1284 bp
ATGGAAACCTTTTGGCTCAGGTTGTCCTTCTGGGTGGCTCTGGTTGGAGGTGTCATCAGT
GATAACCCTGAAAGCTACAGCACAAACCTAAGCATCCATGTGGACAGTGTCGCCACTTTC
CATGGGACAGAACTCAGCTTCGTGGTCACCACACATCAACCCACGAATTTGGCCCTCCCC
AGCAATGGCTCAATGCACAACTATTGCCCACAACAGACTAAGATTACTTCAGCTTTCAAA
TACATTAACACTGTGATATCATGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACC
CTGCTCAGGATCATTTACCAGAACAAGTGCATGAGGAATGGCCCCAACGCGCTGATAGCC
AGCCTTGCCCTGGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG
CTGCTGGCTGGGCGCTGGCCTTTTGAACAAAATGACTTTGGCGTTTTCCTCTGCAAGTTG
TTCCCCTTTTTGCAGAAGTCCTCAGTGGGGATCACCGTCCTTAATCTCTGCGCCCTAAGC
GTTGACAGGTACAGAGCAGTTGCCTCCTGGAGTCGTGTTCAGGGAATTGGGATTCCCTTG
GTCACAGCCATTGAGATTGTCTCCATCTGGATCCTTTCTTTTATCCTGGCCATCCCTGAA
GCCATCGGCTTTGTCATGGTACCTTTTGAATACAAGGGTGCACAGCACAGAACCTGTATG
CTCAATGCCACGTCGAAATTCATGGAGTTCTATCAGGATGTTAAGGACTGGTGGCTGTTC
GGGTTCTACTTCTGCATGCCCCTGGTGTGCACTGCGATCTTTTACACCCTCATGACTTGT
GAGATGTTAAACCGAAGGAACGGCAGCCTGAGAATTGCCCTCAGTGAGCATCTGAAACAG
CGTCGAGAAGTGGCAAAAACAGTTTTCTGCTTGGTTGTAATTTTTGCTCTGTGCTGGTTC
CCTCTTCATTTAAGCCGCATTTTGAAGAAAACCGTGTATGATGAAATGGACACGAACCGA
TGTGAATTACTTAGTTTCTTGCTGCTCATGGATTACATCGGTATTAACTTGGCAACCATG
AATTCATGTATCAACCCAATAGCTCTATATTTTGTGAGCAAGAAATTTAAAAATTGTTTC
CAGTCTTGCCTCTGCTGCTGCTGTTACCAGTCCAAGAGCCTGATGACTTCGGTGCCCATG
AATGGCACCAGCATCCAGTGGAAGAACCATGAACAAAACAACCATAACACAGAGAGGAGC
AGCCACAAGGACAGTATCAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 427 |
| Molecular Weight
| 48515.0 |
| Theoretical pI
| 8.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 81-102
- 113-132
- 160-181
- 206-229
- 257-278
- 307-328
- 348-372
|
| Protein Sequence
|
>Endothelin-1 receptor
METFWLRLSFWVALVGGVISDNPESYSTNLSIHVDSVATFHGTELSFVVTTHQPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFEQNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGAQHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDTNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
|
| External Links |
|---|
| GenBank ID Protein
| CAA40917.1 |
| UniProtKB/Swiss-Prot ID
| P21450 |
| UniProtKB/Swiss-Prot Entry Name
| EDNRA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X57765 |
| GeneCard ID
| EDNRA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
