Showing Protein Cadherin-2 (BMDBP02745)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02745 |
| Secondary Accession Numbers | None |
| Name | Cadherin-2 |
| Synonyms | Not Available |
| Gene Name | CDH2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 24 |
| Locus | Not Available |
| SNPs | CDH2 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 906 |
| Molecular Weight | 99807.0 |
| Theoretical pI | 4.37 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Cadherin-2 SLCKTGFPEDVYSAVLSRDVLEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYA VRSFPLSSEHSKFLIYAQDKETQEKWQVAVKLSLKPALPEDSVKESREIEEIVFPRQVTK HNGYLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGI FIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLH QVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGD IITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYG EVPENRVDVIVANLTVTDKDQPHTPAWNAIYRISGGDPAGRFAIQTDPNSNDGLVTVVKP IDFETNRMYVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEG LHAGTVLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDSVNGQITTIAVLDRESPNVKAN IYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAEICETPDPNSINITALDYD IDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPP KSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRR DKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRL DERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGS LSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD |
| External Links | |
| GenBank ID Protein | CAA37677.1 |
| UniProtKB/Swiss-Prot ID | P19534 |
| UniProtKB/Swiss-Prot Entry Name | CADH2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DAAA02056501 |
| GeneCard ID | CDH2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |