| Identification |
|---|
| BMDB Protein ID
| BMDBP02753 |
| Secondary Accession Numbers
| None |
| Name
| Cadherin-5 |
| Synonyms
|
Not Available
|
| Gene Name
| CDH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CDH5 |
| Gene Sequence
|
>2352 bp
ATGCAGGCACTCGTGATGCTGCTGGCCACGGGGGCCACCTACTACCTGGGCCTGCTGGCA
GCAGCTGCAGCAGCCGTCAACCCTGGCCGACCCAACACCCCCGGCTCGCTGCCCGCTCAC
CGGCGCCAGAAGAGAGACTGGATCTGGAATCAGATGCACATCGACGAAGAGAGAAATGAC
TCGCTGCCCCATTACGTGGGCAAGATTAAATCGAGTGTGGACCCCAAGAAGACCGAGTAC
CAGCTCAGAGGAGAGTCTGCCGGCAAGGTGTTCCGGGTCGACAAGAACACAGGCGATGTG
TACGCCTTAGAGAGGCTGGACAGGGAGAAGATCTCCGAGTACCACCTCACTGCCCTTGTG
GTGGACAAGGACTCCAAGAAGAACCTGGAGTCTCCTTCTAGCTTCACCATCAAAGTTCAC
GATGTCAACGATAACTGGCCTGTGTTTACCCACCGGGTGTTCAATGCCTCTGTGCCCGAG
ATGTCAGGGATAGGGACCTCGGTTATCCAGGTGACAGCGATGGATGCAGATGACCCCACG
GTGGCAGACCATGCTTCTGTCGTGTACCAGCTCACAAAGGGAAAAGAAAATTTCGACATC
CGTGGTTCTGGACTCATTGTCACCATGAACAAACACCTGGACCGAGAGACGCAGGACAAG
TACGAGGTTGTGGTGAAAGCAGAAGATGCCCAGGGCCGCAGGGGGGAGTCAGGCACAGCC
ACTGTGTTCATCACGCTGCAGGACGTCAACGACAACTTCCCCATCTTCACCCAGAACAGG
TATACATTTTCTGTGCCAGAAGACATCCGTGTGGGCAGCCCCCTGGGCTCTCTGTTTGTT
GAGGACCCAGACGAGCCCCAAAACCGGAAGACCAAGTACAGCTTCGTGCAGGGAGAGTAC
AGGGACACCTTCACCATCGATACGGACCCCAGCCACAACGAGGGCATCATCAAGCCCATA
AAGCCCCTGGACTATGAACGCATCCGGCAATACAGCTTCACCATCGAGGCCACAGACCCC
ACCATTGACCTCCGCTACCTGGGCAGCACCTCCCCCAAGAACATCGCCCGTGTCATTATC
AACGTCACAGACGTGGATGAGCCCCCCATCTTCCAGCAACCTTTTTACCACTTCCAGCTG
CAGGAGAACCAGAAGAAGCCTCTGATTGGCTCAGTGCTGGCCAAGGACCCTGATGCTGCT
CAGCGGGACATCAGGTACTCCATCCGCAGGACCAGTGACAAGGGCCAGTTCTTCGGAATA
ACCAAGAAAGGGGGCATTTACAACGACAAAGAACTGGACAGAGAAGTGTACCCTTGGTAC
AACCTGACAGTGGAGGCCAAAGAGGTGGATCTGAGTGGGACTCCCACGGGCAAAGAATCC
ATTGTGCAGGTCCACATTGAAGTTATGGATGAGAATGACAATGCCCCAGAGTTCGCCAAG
CCTTATGAGCCCAAAGTGTGTGAGAACGCCCCCCAGGGCAAGCTGGTCGTGCAAATCTCG
GCAACAGACAAGGATATAACACCACGAGACGTGAAGTTCAAGTTCTCCCTGAGCACTGAG
GACAGCAACTTCACCCTCATTGATAATCACGATAACACGGCCAACATCATAGTCAAGTAC
GGGTATTTTGACCGGGAGCGCGCCAAGGTCCACCACCTGCCCGTGCTCATCTCGGACAAC
GGGAGGCCAAGCCTCACGGGCACCAGCACGCTGCACGTGACCGTGTGCAAGTGCAACGAG
CACGGCGAGTTCACCCTGTGCGAGGAGGCGGCCGCCCAGGTGGGCATCAGCATCCAGGCG
CTCGTCGCCATTTTCCTCTGCATCCTCACCTTCACAGTGATCACCCTCCTCATCATTCTG
CGGAGGCGGCTCCGGAAGCAGGCCCGCGCCCATGGCAAGAGCGTGCCGGAGATCCACGAG
CAGCTGGTCACCTACGATGAGGAGGGCGGTGGCGAGATGGACACCACCAGCTACGACGTG
TCAGTGCTCAACTCTGCGCGCCATGGCGGGGCCAAGCCCCCACGCCCGGCCCTGGACGCG
CGGCCGTCTCTTTACGCTCAGGTGCAGAAGCCACCCCGGCAAGCGCCCGGGGCGCATGCA
CCCGGGGAGATGGCCGCCATGATCGGGGTGAAGAAGGACGAGGCGGACCACGACGGCGGC
GGCCCACCCTATGACACGCTGCACATCTATGGCTACGAGGGCGCCGAGTCCATTGCCGAG
TCCCTCAGCTCCCTGGGCACGGATTCATCGGACTCGGACATTGATTACGACTTTCTCAAT
GACTGGGGAACGAGGTTCAAGATGCTGGCCGAGCTGTATGGCTCAGACCCCCAGGAGGAG
CTGGTGTATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 783 |
| Molecular Weight
| 87467.0 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-5
MQALVMLLATGATYYLGLLAAAAAAVNPGRPNTPGSLPAHRRQKRDWIWNQMHIDEERND
SLPHYVGKIKSSVDPKKTEYQLRGESAGKVFRVDKNTGDVYALERLDREKISEYHLTALV
VDKDSKKNLESPSSFTIKVHDVNDNWPVFTHRVFNASVPEMSGIGTSVIQVTAMDADDPT
VADHASVVYQLTKGKENFDIRGSGLIVTMNKHLDRETQDKYEVVVKAEDAQGRRGESGTA
TVFITLQDVNDNFPIFTQNRYTFSVPEDIRVGSPLGSLFVEDPDEPQNRKTKYSFVQGEY
RDTFTIDTDPSHNEGIIKPIKPLDYERIRQYSFTIEATDPTIDLRYLGSTSPKNIARVII
NVTDVDEPPIFQQPFYHFQLQENQKKPLIGSVLAKDPDAAQRDIRYSIRRTSDKGQFFGI
TKKGGIYNDKELDREVYPWYNLTVEAKEVDLSGTPTGKESIVQVHIEVMDENDNAPEFAK
PYEPKVCENAPQGKLVVQISATDKDITPRDVKFKFSLSTEDSNFTLIDNHDNTANIIVKY
GYFDRERAKVHHLPVLISDNGRPSLTGTSTLHVTVCKCNEHGEFTLCEEAAAQVGISIQA
LVAIFLCILTFTVITLLIILRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDV
SVLNSARHGGAKPPRPALDARPSLYAQVQKPPRQAPGAHAPGEMAAMIGVKKDEADHDGG
GPPYDTLHIYGYEGAESIAESLSSLGTDSSDSDIDYDFLNDWGTRFKMLAELYGSDPQEE
LVY
|
| External Links |
|---|
| GenBank ID Protein
| AAQ63484.1 |
| UniProtKB/Swiss-Prot ID
| Q6URK6 |
| UniProtKB/Swiss-Prot Entry Name
| CADH5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY363224 |
| GeneCard ID
| CDH5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
