Identification
BMDB Protein ID BMDBP02760
Secondary Accession Numbers None
Name Desmoglein-1
Synonyms Not Available
Gene Name DSG1
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 24
Locus Not Available
SNPs DSG1
Gene Sequence
>3132 bp
ATGAACTGGCCCTTCTTCAGAGCAGCTGTGGTGCTGTTCATTTTCCTGGTGGTGCTGGAA
GTTAACAGTGACTTTAGAATCCAGGTCAGGGATTATAACACTAAAAATGGCACCATCAAG
TGGCACTCCCTCAGGAGGCAAAAGCGCGAGTGGATCAAGTTTGCTGCAGCCTGCCGGGAA
GGGGAGGACAACTCAAAGAGGAACCCGATCGCCAAAATTCACTCAGATTGCGCTGCAAAC
CAGCAAGTTACATACCGCATCTCTGGAGTAGGAATCGATCAGCCACCTTATGGAATCTTT
GTTATTAATCAAAAAACTGGTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACC
CCTTTTTTCATTATCTATTGCCGGGCTCTGAATTCACTGGGCCAAGATTTAGAGAAACCT
CTTGAGCTTAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTATTTTCTATGTCT
ACTTTTGTAGGAGAAATAGAAGAAAATTCTAACGCAAATACACTGGTGATGGTACTCAAT
GCTACTGATGCAGATGAACCAAATAATTTGAACTCAAAAATAGCCTTCAAGATCATAAGA
CAAGAACCTTCAGATTCACCGATGTTTATTATCAACAGATACACTGGAGAAATTCGAACA
ATGAATAATTTTCTAGACAGAGAGCAATATGGCCAGTACTCTCTAGCTGTAAGAGGCTCA
GACCGAGATGGTGGGGCAGATGGTATGTCAGCAGAGTGTGAATGCAACATTAAAATCCTC
GATGTCAATGATAACATTCCATACATGGAACTGCCAACACAATCCATAAGCATTGAAGAA
AATTCTCTGAATTCAAATTTGCTCCAGATTAGAGTAATAGATTTGGATGAGGAGTTCTCA
GCTAACTGGATGGCAGTCATTTTCTTCATCTCCGGAAATGAGGGGAATTGGTTTGAAATA
GAAATGAATGAAAGAACAAATGTGGGAACTTTAAAGGTTGTTAAGCCCCTAGATTTTGAA
GCTATGAATAATCTGCAACTTAGTCTTGGTGTTAGAAATAAAGCTGAATTTCATCAATCA
ATTATGTCTCAATATAAACTCACAGCAACTGCAATCTCTGTGACCGTGTTAAACGTAGTT
GAAGGCTCAGTGTTCCGTCCAGGTTCAAAGACATTTGTAGTAAATAGTAATATGGGACAA
AACTATAAAATAGGAGAGTATGTAGCTTGGGATCTCGACGCAAATCGGCCTTCAACAACT
GTTAGATACGTAATGGGAAGAAATCCAACTGACTTGCTCGCTATTGACTCAAAAACAGCC
ATAATTACTTTGAGAAATAAAGTTACTATGGAACAATACAAAATACTTGGGGGAAAATAC
CAAGGAACAATTCTATCTATAGATGATGCTCTTCAAAGAACTTGTACTGGTACAATTGTT
ATTAACCTTGAAAATGGTGGCTGGAAAACTGAACGTCCAAATGTAAATGGAAGTACTACC
TCTGCATATGGCCTTACTTCCGGAGGTGTTACCACTAATGGCTACACAACTGGTGGTGGT
GTTGGCACAGTTACTTTTGCTGTTGGCACAAATGGTTATGGTGTAGGAACTGGTGTTTAT
CAGCCACTAAGAGATAATGTACATTTTGGTCCTGCTGGCATTGGACTACTCATCATGGGA
TTCTTGGTCCTAGGATTGGTCCCCTTCTTGCTGATGTGCTGTGACTGTGGAGGCGCCCCT
GGCGGCGGGGCTGCCTTTGAGCCTGTTCCTGAATGTTCCGATGGAGCAATTCACTCGTGG
GCAGTGGAAGGTGCACAGGCCGATCCTGGGGTTCTGGCCAATAGTGCTGTACCATGCATA
CCAGTCACTAATGCAAATGTAATTGAGTATGTTGACAACTCAGGAGTTTACACAAATGAG
TATGGTGCCAGAGAAATGCAAGATCTGGGAGGAGGAGAAAGAACGACAGGATTTGAACTA
ACAGATGGAGTTAAAATGTCAGGAGGACCTGAGATATGTCAAGAATATCCTGGAACACTA
AGAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGGCTGAATATGAACTTCATGGAAAGT
TACTTCTGCCAGAAAGCATATGCTTATGCGGATGAAGACGAAGGACGCCCATCCAATGAC
TGTCTGCTAATCTACGATATTGAGGGTGCAGGCTCCCCTGCGGGCTCTGTGGGCTGTTGT
AGCTTCATTGGAGAAGACTTGGATGACAGCTTCTTGGATACACTGGGGCCGAAGTTTAAG
AAGTTGGCAGACATCAGCCTGGGAAAAGACGTTGAACCATTTCCAGACTCTGATCCCTCT
TGGCCACCTAAGAGCACTGAGCCGGTCTGCCCTCCGCAGGGAACAGAGCCCACTGGTGGT
GGACACCCACCCATCTCCCCACGTTTCGGCACCACCACCGTCATCTCTGAGAACACCTAC
CCCTCGGGACCTGGGGTACAGCACCCTACGCCGATTCCTGATCCTCTGGGCTATGGTAAT
GTCACCGTGACCGAGTCTTACACCTCCTCGGGCACTCTGAAGCCCTCTGTCCACATTCAC
GATAACCGACACGCATCAAACGTGGTGGTGACAGAGCGGGTAGTCGGTCCAATCTCCGGT
GCCGACTTGCAGGGGATGCTAGAGATGCCTGACTTGAGAGACGGGTCAAACGTGATAGTG
ACAGAAAGGGTAATAGCACCAAGTTCAAGTCTGCCCACCACTCTGACCATCCCTGATCCT
AGGCAGTCTTCCAATGTAGTAGTGACGGAAAGAGTGATCCAGCCAACTTCCGGCATAGTG
GGCAATCTGAGCATGCACCCTGAGTTATCAAACACCCACAACGTGATTGTGACGGAGAGG
GTAGTTTCCGGCTCCGGCATCACGGGCAGCAGCAGCCTGCTGGGCAGTGCAGGTGGAGGA
AGTGGTGGTGGCATCGGGCTGGGCAGCCTAGGAGGTGGCGGGGGCCTGAGTAGCAGCCTA
GGGGGCGCAGCCACCATCGGCCACTTGAGGGGTTCCGCTGAGCATCACTTTAGCAACACC
CTCGGTTCCGCCTCCCCTACCACAACCCGGAGTCGAATCACAAAGTACAGTACAGTTCAA
TATACCAAGTAG
Protein Properties
Number of Residues 1043
Molecular Weight 112243.0
Theoretical pI 4.71
Pfam Domain Function Not Available
Signals
  • 1-23
Transmembrane Regions
  • 552-572
Protein Sequence
>Desmoglein-1
MNWPFFRAAVVLFIFLVVLEVNSDFRIQVRDYNTKNGTIKWHSLRRQKREWIKFAAACRE
GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT
PFFIIYCRALNSLGQDLEKPLELRVRVLDINDNPPVFSMSTFVGEIEENSNANTLVMVLN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDREQYGQYSLAVRGS
DRDGGADGMSAECECNIKILDVNDNIPYMELPTQSISIEENSLNSNLLQIRVIDLDEEFS
ANWMAVIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDFEAMNNLQLSLGVRNKAEFHQS
IMSQYKLTATAISVTVLNVVEGSVFRPGSKTFVVNSNMGQNYKIGEYVAWDLDANRPSTT
VRYVMGRNPTDLLAIDSKTAIITLRNKVTMEQYKILGGKYQGTILSIDDALQRTCTGTIV
INLENGGWKTERPNVNGSTTSAYGLTSGGVTTNGYTTGGGVGTVTFAVGTNGYGVGTGVY
QPLRDNVHFGPAGIGLLIMGFLVLGLVPFLLMCCDCGGAPGGGAAFEPVPECSDGAIHSW
AVEGAQADPGVLANSAVPCIPVTNANVIEYVDNSGVYTNEYGAREMQDLGGGERTTGFEL
TDGVKMSGGPEICQEYPGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSND
CLLIYDIEGAGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKDVEPFPDSDPS
WPPKSTEPVCPPQGTEPTGGGHPPISPRFGTTTVISENTYPSGPGVQHPTPIPDPLGYGN
VTVTESYTSSGTLKPSVHIHDNRHASNVVVTERVVGPISGADLQGMLEMPDLRDGSNVIV
TERVIAPSSSLPTTLTIPDPRQSSNVVVTERVIQPTSGIVGNLSMHPELSNTHNVIVTER
VVSGSGITGSSSLLGSAGGGSGGGIGLGSLGGGGGLSSSLGGAATIGHLRGSAEHHFSNT
LGSASPTTTRSRITKYSTVQYTK
GenBank ID Protein CAA41380.1
UniProtKB/Swiss-Prot ID Q03763
UniProtKB/Swiss-Prot Entry Name DSG1_BOVIN
PDB IDs Not Available
GenBank Gene ID X58466
GeneCard ID DSG1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available