| Identification |
|---|
| BMDB Protein ID
| BMDBP02780 |
| Secondary Accession Numbers
| None |
| Name
| Calcineurin B homologous protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CHP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| CHP1 |
| Gene Sequence
|
>588 bp
ATGGGGTCCCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAA
ACTGGCTTTTCTCACAGTCAGATCACCCGCCTCTACAGCCGGTTCACCAGCCTGGACAAA
GGAGAGAATGGGACTCTCAGCCGGGAAGACTTTCAGCGGATTCCAGAACTTGCCATCAAC
CCATTGGGGGACCGGATCATCAACGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTC
CGGGGATTCATGAGAACCTTGGCTCATTTCCGACCCATTGAGGATAATGAAAAGAGCAAA
GATGTGAATGGACCAGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA
CTGTATGACTTGGATAAAGATGACAAGATCTCCCGTGATGAGCTGTTACAGGTGCTACGC
ATGATGGTCGGAGTGAATATCTCAGATGAGCAGCTGGGCAGCATTGCAGACAGGACCATC
CAGGAGGCTGATCAGGATGGGGACAGCGCCATCTCTTTCACAGAATTTGTTAAGGTTTTG
GAGAAGGTGGACGTAGAACAGAAAATGAGCATCCGATTTCTTCACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 22442.0 |
| Theoretical pI
| 4.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 20-39
- 59-78
- 109-130
- 151-175
- 195-218
|
| Protein Sequence
|
>Calcium-binding protein p22
MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR
LYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL
EKVDVEQKMSIRFLH
|
| External Links |
|---|
| GenBank ID Protein
| ABS45031.1 |
| UniProtKB/Swiss-Prot ID
| Q3SYS6 |
| UniProtKB/Swiss-Prot Entry Name
| CHP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT030715 |
| GeneCard ID
| CHP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
