Identification
BMDB Protein ID BMDBP02786
Secondary Accession Numbers None
Name DSC1 protein
Synonyms Not Available
Gene Name DSC1
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 24
Locus 24q21-q22
SNPs DSC1
Gene Sequence
>2682 bp
ATGGCTGTGGCCTCTGCCGCCCCAGGGAGCATCTTCTGGAAGCAGCTCCTATTCTCTCTC
CTGGTTTTAATATTATTTTGCGATGCTTGTCAGAAAATTTCTCTTCAAGTTCCTTCTCAT
CTTCGGGCTGAAGCACTTGTAGGCAAAGTGAATCTGAAGGAGTGTCTCCAGTCGGCCAGC
CTAATCCTGTCAAGTGATCCTGACTTCAGGATTCTAGAAGATGGCTCCATTTACACAACA
CATGACCTTGTTTTGTCTTCTGGAAAGAGTTTTTCGATTTTGCTCTCAGACAGTCAGGGA
CAGGGGCAGAAGGAGATAGAAATCATACTGGAAGCAGGAGGAAAGAAGGTTCCTAAGAGA
CATATGAAAGACGCAGTCCTCAGGCGAAGCAAGAGGCGATGGGCGCCTATTCCGTGTTCG
CTGATGGAGAACTCACTAGGTCCATTTCCACAGCATGTGCAGCAGGTTCAGTCTGATGCT
GCACAAAACTACACCATCTTTTACTCCATAAGCGGACCAGGGGTAGACAAAGAGCCCTTC
AATCTGTTCTTCATAGAAAAAGATACAGGGGATATATTTTGTACAAGAAGCATAGACCGT
GAGCAATATCAAGAGTTTCCGATCTATGCCTATGCGACCACTGCAGATGGTTATGCACCT
GAGTATCCACTTCCCCTAGTATTCAAAGTTGAAGATGACAATGATAATGCCCCATATTTT
GAAAACAAACTGACCGTCTTTACTGTGCCTGAGAATTGCCGAACTGGAACTTCAGTGGGA
AAAGTGACTGCAATAGACCTCGATGAGCCTGACACTCTACATACTCGTCTGAAGTACAAA
ATCTTGCAGCAAATTCCAAACAATCCAAGACATTTCACTGTACATCCAGACACAGGTGTC
ATCACCACAACCACACCTTTACTGGATAGAGAAAAATGTGATACGTATAAGTTAATAATG
GAAGTTCGAGACATGGGGGGCCAACCTTTTGGTTTATTTAACACAGGAACAATTACTATT
TCTCTTGAGGATGAAAATGATAATGCACCATATTTTACAGAAACTTCTTATACTGTAGAA
GTAGAAGAAAACAGAATTGATGTTGAAATTTTACGAATGGCGGTGCATGACCATGATTTG
CCAAACACGCCGCACTCGAGGGCTGTGTACCAGATCCTACAGGGAAATGAAAACGGAACC
TTCAAAATTAGTACAGACCCAAATACAAATGAAGCGGTCTTGTGTGTTGTCAAGCCACTG
AACTATGAAGTCAATCGCCAAGTTGTTTTGCAAATTGGTGTACTTAACGAAGCACAATTC
GCTAAGGCAGTAAACTCAAAAACTACTACGACTATGTGTACTACAGTTGTCACTGTTAAA
GTTAAAGACCATGATGAGGGCCCTGAGTGCCAGCCACCAGTAAAAGTCATTCAGAGTGAA
GACTGCCTCCCCGCAGGCACAGAGCTCCTTGGATACAAAGCAGTGGACCCGGAAAGGGGC
ACTGGCGAGGGCTTAAGGTATAAGAAGATACAAGATGAAGATAACTGGTTTGAAATTAAT
GAATACACTGGTGACTTGAAAACTGTAAAAGTGCTAGATAGAGAATCAACATTTGTAAAA
AACAACCAATACAATGTTTCTGTGATTGCGTTCGATGCAGATGGCAGATCTTGCACTGGA
ACGTTAGTAGTTTTTTTGGAAGATAAAAATGACCACCCACCGCAGATAAAACAAGAAGAA
CTGACAATTTGCCGGCATGATAAGGATTATGTTGTCCTCGAACCTACAGATCAAGATGGA
CCTGACAATGGGCCACCTTTTCAATTCATTCTTGATAATTCTGCCAGCAAACTTTGGACA
GTAGAGACAAGGGATGGTAAAACTGCCATTCTTCGGGGGCGGCAAGATCTTGATTATGAC
TATTACACTGTTCCTATCCAAATAAAAGACAGACATGGTGCTTCTGCAACACACATATTA
CCAGTGAGAGTATGTGATTGTACAATTCCATCCGAATGTAGAATGCCTAGTAAACTTTCG
AGAGAGGCAGCACTCGCAAATGTATTCCTTGGAAAATGGGCAATTCTTGCCATGGTGTTG
GGTTCTGTATTGTTGTTATGTATTTTGTTCACATGTTTCTGTGTTACTGTTAAGAAAACA
GTAAAGAAGTGTTTTCCAGAAGATGTAGCCCAGCAAAATTTAATTGTATCAAATACTGAA
GGACCTGGAGAAGAAGTGATGGATGCAAATATTAGACTCCCCACACAGACATCCAACGTT
TGTGACACAAGCATATCTGTTGGCACACTTGGTGGCCAGGGAGTCAAAACACAGCAAAGT
TTTGAGATGGTCAAAGGCGGCTACACTTTGGATGCCAACAAAGGAGGTGGACATCAGACC
CTGGAATCTGTTAAGGGAGTGACGGACACTGGCAGATACACGTACAGTGACTGGCACAAC
TTCACCCAACCTCGGCTTGGCGAAAAGGTGTATCTGTGCGGACAAGACGAGGAACACAAG
CTCTGCGAAGACTACGTTCGCTCCTATAGCTATGAAGGCAAAGGGTCTGTGGCCGGCTCA
GTGGGCTGCTGCAGCGATCGGCAGGAAGAAGAGGGGCTTGACTTCCTAGATCATCTGGAA
CCCAAATTTAGGACGCTAGCGAAAACATGTGTAAAGAAATAA
Protein Properties
Number of Residues 893
Molecular Weight 99604.0
Theoretical pI 4.89
Pfam Domain Function Not Available
Signals
  • 1-29
Transmembrane Regions
  • 693-717
Protein Sequence
>DSC1 protein
MAVASAAPGSIFWKQLLFSLLVLILFCDACQKISLQVPSHLRAEALVGKVNLKECLQSAS
LILSSDPDFRILEDGSIYTTHDLVLSSGKSFSILLSDSQGQGQKEIEIILEAGGKKVPKR
HMKDAVLRRSKRRWAPIPCSLMENSLGPFPQHVQQVQSDAAQNYTIFYSISGPGVDKEPF
NLFFIEKDTGDIFCTRSIDREQYQEFPIYAYATTADGYAPEYPLPLVFKVEDDNDNAPYF
ENKLTVFTVPENCRTGTSVGKVTAIDLDEPDTLHTRLKYKILQQIPNNPRHFTVHPDTGV
ITTTTPLLDREKCDTYKLIMEVRDMGGQPFGLFNTGTITISLEDENDNAPYFTETSYTVE
VEENRIDVEILRMAVHDHDLPNTPHSRAVYQILQGNENGTFKISTDPNTNEAVLCVVKPL
NYEVNRQVVLQIGVLNEAQFAKAVNSKTTTTMCTTVVTVKVKDHDEGPECQPPVKVIQSE
DCLPAGTELLGYKAVDPERGTGEGLRYKKIQDEDNWFEINEYTGDLKTVKVLDRESTFVK
NNQYNVSVIAFDADGRSCTGTLVVFLEDKNDHPPQIKQEELTICRHDKDYVVLEPTDQDG
PDNGPPFQFILDNSASKLWTVETRDGKTAILRGRQDLDYDYYTVPIQIKDRHGASATHIL
PVRVCDCTIPSECRMPSKLSREAALANVFLGKWAILAMVLGSVLLLCILFTCFCVTVKKT
VKKCFPEDVAQQNLIVSNTEGPGEEVMDANIRLPTQTSNVCDTSISVGTLGGQGVKTQQS
FEMVKGGYTLDANKGGGHQTLESVKGVTDTGRYTYSDWHNFTQPRLGEKVYLCGQDEEHK
LCEDYVRSYSYEGKGSVAGSVGCCSDRQEEEGLDFLDHLEPKFRTLAKTCVKK
GenBank ID Protein AAI50134.1
UniProtKB/Swiss-Prot ID A6QR67
UniProtKB/Swiss-Prot Entry Name A6QR67_BOVIN
PDB IDs Not Available
GenBank Gene ID BC150133
GeneCard ID DSC1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available