Showing Protein Annexin A2 (BMDBP02788)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02788 |
| Secondary Accession Numbers | None |
| Name | Annexin A2 |
| Synonyms | Not Available |
| Gene Name | ANXA2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | ANXA2 |
| Gene Sequence |
>1020 bp CTTCTTTCAAAATGTCTACCGTTCATGAAATTCTGTGCAAGCTCAGTTTGGAGGGTGATC ACTCCACACCTCCAAGTGCATACGGGTCAGTCAAAGCGTACACTAACTTTGATGCTGAGC GGGATGCTCTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATCG TCAACATCCTGACCAACCGCAGCAATGAACAGAGACAGGATATTGCCTTCGCCTACCAGA GAAGGACCAAGAAGGAACTTGCATCAGCACTGAAGTCAGCCTTGTCTGGCCACCTGGAGA CAGTGATTTTGGGCCTATTGAAAACACCTGCTCAGTATGATGCTTCTGAGCTGAAAGCGT CCATGAAGGGGCTGGGGACTGATGAGGACTCTCTCATTGAGATCATCTGCTCAAGGACCA ACCAGGAGCTGCAGGAAATCAACAGAGTCTACAAGGAAATGTACAAGACCGATCTGGAGA AGGACATCGTTTCCGACACATCTGGCGACTTCCGCAAGCTGATGGTCGCCCTCGCAAAGG GTCGGAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAGGATGCCAGGG ATCTCTATGATGCTGGTGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCA TGACCGAGCGGAGCGTGTGCCACCTCCAGAAAGTATTTGAAAGGTACAAGAGCTACAGCC CTTACGACATGCTGGAGAGCATCAAGAAGGAGGTCAAAGGAGACCTGGAAAATGCCTTTC TGAATCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGACAGACTGTATGACT CCATGAAGGGCAAGGGCACTCGCGACAAGGTCCTGATTAGAATCATGGTCTCGCGCAGTG AAGTGGACATGTTGAAAATTAGATCTGAGTTCAAGAAAAAGTACGGCAAGTCCCTGTACT ACTATATTCAGCAAGACACCAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTG |
| Protein Properties | |
| Number of Residues | 339 |
| Molecular Weight | 38612.0 |
| Theoretical pI | 7.39 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Annexin A2 MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIL TNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRA EDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDM LESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDM LKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD |
| External Links | |
| GenBank ID Protein | AAA30421.1 |
| UniProtKB/Swiss-Prot ID | P04272 |
| UniProtKB/Swiss-Prot Entry Name | ANXA2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | M14056 |
| GeneCard ID | ANXA2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |