Identification
BMDB Protein ID BMDBP02859
Secondary Accession Numbers None
Name Elongation of very long chain fatty acids protein 5
Synonyms Not Available
Gene Name ELOVL5
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).
Pathways Not Available
Reactions
Eicosapentaenoic acid → Clupanodonic acid details
Clupanodonic acid → Tetracosapentaenoic acid (24:5n-3) details
Gamma-Linolenic acid → 8,11,14-Eicosatrienoic acid details
Arachidonic acid → Docosatetraenoic acid details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 23
Locus Not Available
SNPs ELOVL5
Gene Sequence Not Available
Protein Properties
Number of Residues 299
Molecular Weight 35377.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 26-46
  • 64-84
  • 112-132
  • 139-158
  • 168-187
  • 205-225
  • 226-246
Protein Sequence Not Available
GenBank ID Protein AAI05392.1
UniProtKB/Swiss-Prot ID Q2KJD9
UniProtKB/Swiss-Prot Entry Name ELOV5_BOVIN
PDB IDs Not Available
GenBank Gene ID BC105391
GeneCard ID ELOVL5
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available