Identification
BMDB Protein ID BMDBP02917
Secondary Accession Numbers None
Name Phospholipid phosphatase 2
Synonyms Not Available
Gene Name PLPP2
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity).
Pathways Not Available
Reactions
PA(16:0/16:0) → DG(16:0/16:0/0:0) + Hydrogen phosphate details
Sphinganine 1-phosphate + Water → Sphinganine + Hydrogen phosphate details
CerP(d18:1/18:0) + Water → Ceramide (d18:1/18:0) + Hydrogen phosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 7
Locus Not Available
SNPs PLPP2
Gene Sequence Not Available
Protein Properties
Number of Residues 287
Molecular Weight 32328.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 5-25
  • 52-72
  • 88-108
  • 162-182
  • 194-211
  • 219-239
Protein Sequence Not Available
GenBank ID Protein AAI13293.1
UniProtKB/Swiss-Prot ID Q2HJ61
UniProtKB/Swiss-Prot Entry Name PLPP2_BOVIN
PDB IDs Not Available
GenBank Gene ID BC113292
GeneCard ID PLPP2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available